全文获取类型
收费全文 | 2559篇 |
免费 | 189篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 74篇 |
妇产科学 | 101篇 |
基础医学 | 417篇 |
口腔科学 | 24篇 |
临床医学 | 310篇 |
内科学 | 417篇 |
皮肤病学 | 41篇 |
神经病学 | 222篇 |
特种医学 | 183篇 |
外科学 | 259篇 |
综合类 | 64篇 |
预防医学 | 324篇 |
眼科学 | 46篇 |
药学 | 145篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 114篇 |
出版年
2022年 | 18篇 |
2021年 | 47篇 |
2020年 | 13篇 |
2019年 | 27篇 |
2018年 | 30篇 |
2017年 | 26篇 |
2016年 | 23篇 |
2015年 | 34篇 |
2014年 | 58篇 |
2013年 | 90篇 |
2012年 | 108篇 |
2011年 | 120篇 |
2010年 | 86篇 |
2009年 | 106篇 |
2008年 | 90篇 |
2007年 | 113篇 |
2006年 | 135篇 |
2005年 | 108篇 |
2004年 | 100篇 |
2003年 | 90篇 |
2002年 | 97篇 |
2001年 | 102篇 |
2000年 | 80篇 |
1999年 | 70篇 |
1998年 | 74篇 |
1997年 | 57篇 |
1996年 | 51篇 |
1995年 | 50篇 |
1994年 | 36篇 |
1993年 | 36篇 |
1992年 | 54篇 |
1991年 | 55篇 |
1990年 | 41篇 |
1989年 | 53篇 |
1988年 | 51篇 |
1987年 | 47篇 |
1986年 | 46篇 |
1985年 | 48篇 |
1984年 | 24篇 |
1983年 | 24篇 |
1982年 | 21篇 |
1981年 | 15篇 |
1980年 | 16篇 |
1979年 | 13篇 |
1978年 | 14篇 |
1977年 | 13篇 |
1976年 | 15篇 |
1975年 | 19篇 |
1973年 | 12篇 |
1971年 | 10篇 |
排序方式: 共有2769条查询结果,搜索用时 12 毫秒
81.
J L Wiggs G R Howell K Linkroum W Abdrabou E Hodges C E Braine L R Pasquale G J Hannon J L Haines S W M John 《Clinical genetics》2013,84(2):167-174
Primary open angle glaucoma (POAG) is a genetically and phenotypically complex disease that is a leading cause of blindness worldwide. Previously we completed a genome‐wide scan for early‐onset POAG that identified a locus on 9q22 (GLC1J). To identify potential causative variants underlying GLC1J, we used targeted DNA capture followed by high throughput sequencing of individuals from four GLC1J pedigrees, followed by Sanger sequencing to screen candidate variants in additional pedigrees. A mutation likely to cause early‐onset glaucoma was not identified, however COL15A1 variants were found in the youngest affected members of 7 of 15 pedigrees with variable disease onset. In addition, the most common COL15A1 variant, R163H, influenced the age of onset in adult POAG cases. RNA in situ hybridization of mouse eyes shows that Col15a1 is expressed in the multiple ocular structures including ciliary body, astrocytes of the optic nerve and cells in the ganglion cell layer. Sanger sequencing of COL18A1, a related multiplexin collagen, identified a rare variant, A1381T, in members of three additional pedigrees with early‐onset disease. These results suggest genetic variation in COL15A1 and COL18A1 can modify the age of onset of both early and late onset POAG. 相似文献
82.
Janneke AL van Kempen Henk J Schers Anne Jacobs Sytse U Zuidema Franca Ruikes Sarah HM Robben René JF Melis Marcel GM Olde Rikkert 《The British journal of general practice》2013,63(608):e225-e231
Background
Primary care is increasingly interested in the identification of frailty, as it selects the target population for integrated care. However, instruments for the identification of frailty specifically validated for use in primary care are scarce. This study developed the Easycare Two-step Older persons Screening (Easycare-TOS), which provides a valid, efficient, and pragmatic screening procedure to identify frail older people.Aim
This paper aims to describe the development of the Easycare-TOS and the data from the pilot studies.Design and setting
Observational pilot study in seven academic GP practices in and around Nijmegen, The Netherlands.Method
The Easycare-TOS was developed in a cyclic process with the input of stakeholders. In every cycle, the requirements were first defined, then translated into a prototype that was tested in a pilot study. The Easycare-TOS makes optimal use of prior knowledge of the GP, and the professionals’ appraisal is decisive in the frailty decision, instead of a cut-off score. Further, it considers aspects of frailty, as well as aspects of the care context of the patient.Results
The pilot data have shown that after step 1, two-thirds of the patients do not need further assessment, because they are judged as not frail, based on prior knowledge of the GP. The overall prevalence of frailty in this pilot study is 24%. Most professionals who participated in the pilot studies considered the time investment acceptable and the method to be of added value.Conclusion
The Easycare-TOS instrument meets the predefined efficiency, flexibility, and acceptability requirements for use as an identification instrument for frailty in primary care. 相似文献83.
84.
85.
Christopher J. Bradley David E. Haines 《Journal of cardiovascular electrophysiology》2020,31(8):2136-2147
Pulsed‐field ablation (PFA) is a promising new ablation modality for the treatment of atrial fibrillation. This energy form employs a train of microsecond duration high amplitude electrical pulses that ablate myocardium by electroporation of the sarcolemmal membrane without measurable tissue heating. The ablation pulse waveform has multiple variable components that can affect ablation efficacy, thus each proprietary system has unique properties that cannot be generalized to other systems. Success with PFA depends upon the proximity of the electrode to the target tissue, but not necessarily upon contact. A unique feature of PFA is tissue specificity. Myocardium is very susceptible to irreversible injury whereas the esophagus, phrenic nerves, pulmonary veins, and coronary arteries are relatively resistant to injury. The tissue specificity of PFA may result in a wide therapeutic range and improved safety profile during atrial fibrillation ablation. Vein isolation can be achieved very rapidly (seconds) promising that PFA may reduce procedure time to 1 hour or less. This attractive new technology promises to be a major advance in the field of atrial fibrillation ablation. 相似文献
86.
The incidence of cardiac hypertrophy, an established risk factor for heart failure, is generally lower in women compared with men, but this advantage is lost after menopause. Although it is widely believed that estrogens are cardioprotective, there are contradictory reports, including increased cardiac events in postmenopausal women receiving estrogens and enhanced cardiac protection from ischemic injury in female mice without estrogens. We exposed aromatase knockout (ArKO) mice, which produce no estrogens, to both pathologic and physiologic stimuli. This model allows an investigation into the effects of a complete, chronic lack of estrogens in male and female hearts. At baseline, female ArKO mice had normal-sized hearts but decreased cardiac function and paradoxically increased phosphorylation of many progrowth kinases. When challenged with the pathological stimulus, isoproterenol, ArKO females developed 2-fold more hypertrophy than wild-type females. In contrast, exercise-induced physiological hypertrophy was unaffected by the absence of estrogens in either sex, although running performance was blunted in ArKO females. Thus, loss of estrogen signaling in females, but not males, impairs cardiac function and sensitizes the heart to pathological insults through up-regulation of multiple hypertrophic pathways. These findings provide insight into the apparent loss of cardioprotection after menopause and suggest that caution is warranted in the long-term use of aromatase inhibitors in the setting of breast cancer prevention. 相似文献
87.
88.
89.
Calkins H Kuck KH Cappato R Brugada J Camm AJ Chen SA Crijns HJ Damiano RJ Davies DW DiMarco J Edgerton J Ellenbogen K Ezekowitz MD Haines DE Haissaguerre M Hindricks G Iesaka Y Jackman W Jalife J Jais P Kalman J Keane D Kim YH Kirchhof P Klein G Kottkamp H Kumagai K Lindsay BD Mansour M Marchlinski FE McCarthy PM Mont JL Morady F Nademanee K Nakagawa H Natale A Nattel S Packer DL Pappone C Prystowsky E Raviele A Reddy V Ruskin JN Shemin RJ Tsao HM Wilber D 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2012,14(4):528-606
90.
Jess Haines Matthew W. Gillman Sheryl Rifas-Shiman Alison E. Field S. Bryn Austin 《Eating disorders》2013,21(1):10-24
We aimed to examine longitudinal associations between family dinner and disordered eating behaviors among adolescents. We studied 7535 females and 5913 males, 9 to 14 years of age in 1996. We performed multivariable logistic regression to assess the associations of previous year family dinner with 1-year incidence of each of 3 outcomes: purging, binge eating, and frequent dieting. Compared to those who ate family dinner “never or some days,” female adolescents who ate family dinner at least most days were less likely to initiate purging, binge eating, and frequent dieting. Estimates of association among males were similar in direction and magnitude, although lower frequency of the outcomes resulted in less precise estimates and fewer statistically significant results. 相似文献