全文获取类型
收费全文 | 347篇 |
免费 | 42篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 21篇 |
基础医学 | 21篇 |
口腔科学 | 13篇 |
临床医学 | 43篇 |
内科学 | 92篇 |
皮肤病学 | 2篇 |
神经病学 | 15篇 |
特种医学 | 41篇 |
外科学 | 18篇 |
综合类 | 5篇 |
预防医学 | 94篇 |
眼科学 | 4篇 |
药学 | 16篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 2篇 |
2022年 | 6篇 |
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 11篇 |
2017年 | 21篇 |
2016年 | 12篇 |
2015年 | 9篇 |
2014年 | 11篇 |
2013年 | 25篇 |
2012年 | 14篇 |
2011年 | 15篇 |
2010年 | 14篇 |
2009年 | 18篇 |
2008年 | 13篇 |
2007年 | 18篇 |
2006年 | 14篇 |
2005年 | 15篇 |
2004年 | 9篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 8篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 12篇 |
1996年 | 11篇 |
1995年 | 12篇 |
1994年 | 15篇 |
1993年 | 6篇 |
1992年 | 7篇 |
1991年 | 2篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1980年 | 2篇 |
1977年 | 2篇 |
1969年 | 2篇 |
1965年 | 1篇 |
1963年 | 1篇 |
1957年 | 1篇 |
1943年 | 2篇 |
1939年 | 1篇 |
1937年 | 1篇 |
排序方式: 共有401条查询结果,搜索用时 15 毫秒
11.
12.
M Reincke E Fischer S Gerum K Merkle S Schulz A Pallauf M Quinkler G Hanslik K Lang S Hahner B Allolio C Meisinger R Holle F Beuschlein M Bidlingmaier S Endres;Participants of the German Conn's Registry-Else Kröner-Fresenius-Hyperaldosteronism Registry 《Hypertension》2012,60(3):618-624
In comparison with essential hypertension, primary aldosteronism (PA) is associated with an increased risk of cardiovascular morbidity. To date, no data on mortality have been published. We assessed mortality of patients treated for PA within the German Conn's registry and identified risk factors for adverse outcome in a case-control study. Patients with confirmed PA treated in 3 university centers in Germany since 1994 were included in the analysis. All of the patients were contacted in 2009 and 2010 to verify life status. Subjects from the population-based F3 survey of the Cooperative Health Research in the Region of Augsburg served as controls. Final analyses were based on 600 normotensive controls, 600 hypertensive controls, and 300 patients with PA. Kaplan-Meyer survival curves were calculated for both cohorts. Ten-year overall survival was 95% in normotensive controls, 90% in hypertensive controls, and 90% in patients with PA (P value not significant). In multivariate analysis, age (hazard ratio, 1.09 per year [95% CI, 1.03-1.14]), angina pectoris (hazard ratio, 3.6 [95% CI, 1.04-12.04]), and diabetes mellitus (hazard ratio, 2.55 [95% CI, 1.07-6.09]) were associated with an increase in all-cause mortality, whereas hypokalemia (hazard ratio, 0.41 per mmol/L [95% CI, 0.17-0.99]) was associated with reduced mortality. Cardiovascular mortality was the main cause of death in PA (50% versus 34% in hypertensive controls; P<0.05). These data indicate that cardiovascular mortality is increased in patients treated for PA, whereas all-cause mortality is not different from matched hypertensive controls. 相似文献
13.
牛津膝置换是使用最广泛的膝关节单髁置换(UKR)。牛津膝在37年前开始应用,拥有一个全匹配的活动衬垫,因而磨损率非常低。牛津膝最主要的使用指征是膝关节前内侧骨关节炎,这种病人至少占所有需要行膝关节置换术患者的50%。由于这一系统的设计特点,传统UKR的反指征,如年龄、活动量、肥胖、髌股关节损害和软骨钙质沉着症等对于牛津膝均不是反指征。与全膝关节置换(TKR)相比,牛津膝提供更快的康复、更好的功能、更大的活动度和更好的术后满意度,发生并发症更少、程度更轻,病残率和死亡率更低。一个持续超过30年的研究显示在90%的病例中,牛津膝为患者终生提供了优或良的临床结果,且不需要翻修。在最近15年,牛津膝通过微创手术入路植入,涉及6000多例使用该入路牛津膝置换的9个研究报道显示,10年生存率约95%。在许多这样的研究中,医生们在拟行膝关节置换的患者中约50%使用了牛津单髁膝置换。 相似文献
14.
15.
Graft-versus-host disease (GVHD) is currently encountered after bone marrow transplantation and transfusion. GVHD associated with transfusion (TA-GVHD) in apparently immunocompetent recipients has been recently reported with increasing frequency. A consistent finding in many of these cases is that the recipient received blood from a donor homozygous for one of the recipient's HLA haplotypes. However, the observed frequency of TA-GVHD is much lower than the estimated probability of this donor/recipient combination. The potential role of recipient immune responses in controlling TA-GVHD was investigated using an analogous murine model in which GVHD is induced by the injection of parental lymphoid cells into unirradiated F1 hybrid recipients. The effect of various immune manipulations of the recipient of GVHD induction was assessed by determining the number of donor lymphoid cells required to induce GVHD responses. Whereas depletion of recipient CD4+ cells increased the number of donor cells needed to induce GVHD, depletion of recipient CD8+ and natural killer cells resulted in fewer donor cells being needed to induce a GVHD response. These studies suggest a central role for functioning recipient CD8 and natural killer cells in the down-regulation of TA-GVHD development in recipients. 相似文献
16.
Aladdin H. Shadyab PhD JoAnn E. Manson MD DrPH Juhua Luo PhD Bernhard Haring MD MPH Nazmus Saquib PhD Linda G. Snetselaar RD PhD LD Jiu-Chiuan Chen MD ScD Erik J. Groessl PhD Sylvia Wassertheil-Smoller PhD Yangbo Sun MD PhD Lauren Hale PhD Meryl S. LeBoff MD Andrea Z. LaCroix PhD 《Journal of the American Geriatrics Society》2020,68(9):1970-1978
17.
18.
19.
Nicole B. Jacobson RD LD CNSD Neha Parekh MS RD LD CNSD Matt Kalaycio MD 《Current hematologic malignancy reports》2006,1(3):188-194
Patients with acute leukemia who undergo hematopoietic stem cell transplantation (HSCT) are susceptible to malnutrition caused
by several factors including intensive cytotoxic therapy. This paper discusses the significance of malnutrition in these patients
and provides an overview of nutrition therapy by the oral, enteral, and parenteral routes. The goal is to investigate whether
the use of parenteral nutrition (PN) produces improved clinical outcomes in patients with acute leukemia and to identify criteria
for the selection of patients most likely to benefit from this therapy. Although PN may be appropriate for patients suffering
from complications such as graft-versus-host disease (GVHD) and mucositis, the data available at this time do not support
PN as first-line therapy for all recipients of HSCT. 相似文献
20.
Fassnacht M Hahner S Hansen IA Kreutzberger T Zink M Adermann K Jakob F Troppmair J Allolio B 《The Journal of clinical endocrinology and metabolism》2003,88(5):2171-2179
There is evidence that proopiomelanocortin (POMC)-derived peptides other than ACTH are involved in pituitary-dependent adrenal growth. We have synthesized the human N-terminal POMC fragment 1-28-POMC with the disulfide bridges in the correct position between cysteine residues 2-24 and 8-20 and studied the activity of these peptides in adrenocortical tumor cells in vitro. 1-28-POMC stimulated cell proliferation in human NCI-h295 and mouse Y-1 adrenal cancer cell lines and also in primary cultures of bovine adrenocortical cells in a concentration-dependent manner. 1-28-POMC led to rapid activation of the MAPKs extracellular signal-regulated kinases-1 and -2, but not c-Jun N-terminal kinase and p38, pathways. Steroid hormone production (cortisol, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate) in NCI-h295 cells was decreased by 1-28-POMC in a concentration-dependent fashion. However, protein levels of important regulators of steroidogenesis [steroidogenic factor-1, DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-chromosome 1), steroidogenic acute regulatory protein, and cytochrome P450 side-chain cleavage enzyme] remained unaffected by 1-28-POMC treatment. Our results provide evidence that synthetic 1-28-POMC induces adrenal tumor cell proliferation, inhibits adrenal steroidogenesis, and mediates its action by signaling via the extracellular signal-regulated kinase pathway. The distinct roles of 1-28-POMC and ACTH in the regulation of adrenal growth and steroidogenesis suggest that the adrenal cortex is under the dual opposing control of fragments from the same mother peptide POMC. 相似文献