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991.
Ohne ZusammenfassungIII. abschließende Mitteilung. 相似文献
992.
Fritz Hahn 《Naunyn-Schmiedeberg's archives of pharmacology》1948,205(4-5):552-562
Ohne Zusammenfassung 相似文献
993.
Journal of Molecular Medicine - 相似文献
994.
Johanna M. Schwarzer Inga Meyhoefer Linda A. Antonucci Lana Kambeitz-Ilankovic Marian Surmann Olga Bienek Georg Romer Udo Dannlowski Tim Hahn Alexandra Korda Dominic B. Dwyer Anne Ruef Shalaila S. Haas Marlene Rosen Theresa Lichtenstein Stephan Ruhrmann Joseph Kambeitz Raimo K. R. Salokangas Christos Pantelis Frauke Schultze-Lutter Eva Meisenzahl Paolo Brambilla Alessandro Bertolino Stefan Borgwardt Rachel Upthegrove Nikolaos Koutsouleris Rebekka Lencer the PRONIA Consortium 《Neuropsychopharmacology》2022,47(12):2051
Subtle subjective visual dysfunctions (VisDys) are reported by about 50% of patients with schizophrenia and are suggested to predict psychosis states. Deeper insight into VisDys, particularly in early psychosis states, could foster the understanding of basic disease mechanisms mediating susceptibility to psychosis, and thereby inform preventive interventions. We systematically investigated the relationship between VisDys and core clinical measures across three early phase psychiatric conditions. Second, we used a novel multivariate pattern analysis approach to predict VisDys by resting-state functional connectivity within relevant brain systems. VisDys assessed with the Schizophrenia Proneness Instrument (SPI-A), clinical measures, and resting-state fMRI data were examined in recent-onset psychosis (ROP, n = 147), clinical high-risk states of psychosis (CHR, n = 143), recent-onset depression (ROD, n = 151), and healthy controls (HC, n = 280). Our multivariate pattern analysis approach used pairwise functional connectivity within occipital (ON) and frontoparietal (FPN) networks implicated in visual information processing to predict VisDys. VisDys were reported more often in ROP (50.34%), and CHR (55.94%) than in ROD (16.56%), and HC (4.28%). Higher severity of VisDys was associated with less functional remission in both CHR and ROP, and, in CHR specifically, lower quality of life (Qol), higher depressiveness, and more severe impairment of visuospatial constructability. ON functional connectivity predicted presence of VisDys in ROP (balanced accuracy 60.17%, p = 0.0001) and CHR (67.38%, p = 0.029), while in the combined ROP + CHR sample VisDys were predicted by FPN (61.11%, p = 0.006). These large-sample study findings suggest that VisDys are clinically highly relevant not only in ROP but especially in CHR, being closely related to aspects of functional outcome, depressiveness, and Qol. Findings from multivariate pattern analysis support a model of functional integrity within ON and FPN driving the VisDys phenomenon and being implicated in core disease mechanisms of early psychosis states.Subject terms: Predictive markers, Psychosis 相似文献
995.
Joo Myung Lee Hyun Sung Joh Ki Hong Choi David Hong Taek Kyu Park Jeong Hoon Yang Young Bin Song Jin-Ho Choi Seung-Hyuk Choi Jin-Ok Jeong Jong-Young Lee Young Jin Choi Jei-Keon Chae Seung-Ho Hur Jang-Whan Bae Ju-Hyeon Oh Kook-Jin Chun Hyun-Joong Kim Byung Ryul Cho Doosup Shin Seung Hun Lee Doyeon Hwang Hyun-Jong Lee Ho-Jun Jang Hyun Kuk Kim Sang Jin Ha Eun-Seok Shin Joon-Hyung Doh Joo-Yong Hahn Hyeon-Cheol Gwon 《Journal of Korean medical science》2023,38(5)
BackgroundThe risk of device thrombosis and device-oriented clinical outcomes with bioresorbable vascular scaffold (BVS) was reported to be significantly higher than with contemporary drug-eluting stents (DESs). However, optimal device implantation may improve clinical outcomes in patients receiving BVS. The current study evaluated mid-term safety and efficacy of Absorb BVS with meticulous device optimization under intravascular imaging guidance.MethodsThe SMART-REWARD and PERSPECTIVE-PCI registries in Korea prospectively enrolled 390 patients with BVS and 675 patients with DES, respectively. The primary endpoint was target vessel failure (TVF) at 2 years and the secondary major endpoint was patient-oriented composite outcome (POCO) at 2 years.ResultsPatient-level pooled analysis evaluated 1,003 patients (377 patients with BVS and 626 patients with DES). Mean scaffold diameter per lesion was 3.24 ± 0.30 mm in BVS group. Most BVSs were implanted with pre-dilatation (90.9%), intravascular imaging guidance (74.9%), and post-dilatation (73.1%) at proximal to mid segment (81.9%) in target vessel. Patients treated with BVS showed comparable risks of 2-year TVF (2.9% vs. 3.7%, adjusted hazard ratio [HR], 1.283, 95% confidence interval [CI], 0.487–3.378, P = 0.615) and 2-year POCO (4.5% vs. 5.9%, adjusted HR, 1.413, 95% CI, 0.663–3.012, P = 0.370) than those with DES. The rate of 2-year definite or probable device thrombosis (0.3% vs. 0.5%, P = 0.424) was also similar. The sensitivity analyses consistently showed comparable risk of TVF and POCO between the 2 groups.ConclusionWith meticulous device optimization under imaging guidance and avoidance of implantation in small vessels, BVS showed comparable risks of 2-year TVF and device thrombosis with DES.Trial RegistrationClinicalTrials.gov Identifier: , NCT02601404 NCT04265443相似文献
996.
997.
998.
S. Hahn 《Der Gyn?kologe》2000,33(12):915-916
Der diesj?hrige Nobelpreis für Medizin wurde an die drei Hirnforscher Arvid Carlsson (Abb.1a), Paul Greengard (Abb.1b) und Eric Kandel (Abb.1c) vergeben. Seit Jahrzehnten tragen die aus unterschiedlichen Fachrichtungen kommenden Laureaten zum Verst?ndnis der normalen und pathologischen Hirnfunktion bei. Alle drei Preistr?ger sind Pioniere auf dem speziellen Gebiet der neuronalen Signalweiterleitung, das sich mit der langsamen synaptischen Transmission auseinandersetzt. Die Forschungarbeiten des Schweden Carlsson und seiner US-amerikanischen Kollegen erm?glichten einen Einblick, wie gest?rte Prozesse der Signalweiterleitung zu neurologischen und psychiatrischen Erkrankungen wie Parkinson, Depressionen oder Schizophrenie führen k?nnen. Die Ergebnisse führten letztendlich zur Entwicklung neuer Medikamente zur Behandlung dieser Krankheiten. 相似文献
999.
The majority of adult human epithelial cancers exhibit evidence of genetic instability, and it is widely believed that the genetic instability manifested by aneuploidy or microsatellite instability plays an essential role in the genesis of these tumors. Indeed, most experimental models of cancer also show evidence of genomic instability. The resulting genetic chaos, which has widespread effects on many genes throughout the genome, confounds attempts to determine the precise cohort of genetic changes that are required for the transformation of normal human cells to a tumorigenic state. Here we show that genetic transformation of human kidney epithelial cells can occur in the absence of extensive aneuploidy, chromosomal translocations, and microsatellite instability. These observations demonstrate that the in vitro oncogenic transformation of human cells can proceed without widespread genomic instability. 相似文献
1000.
Hye Seong Ahn MD Hyuk‐Joon Lee MD Seokyung Hahn PhD Woo‐Ho Kim MD Kuhn Uk Lee MD Takeshi Sano MD Stephen B Edge MD Han‐Kwang Yang MD 《Cancer》2010,116(24):5592-5598