全文获取类型
收费全文 | 1336960篇 |
免费 | 96107篇 |
国内免费 | 2923篇 |
专业分类
耳鼻咽喉 | 19744篇 |
儿科学 | 40319篇 |
妇产科学 | 38762篇 |
基础医学 | 187513篇 |
口腔科学 | 39854篇 |
临床医学 | 112820篇 |
内科学 | 262882篇 |
皮肤病学 | 30261篇 |
神经病学 | 106573篇 |
特种医学 | 53766篇 |
外国民族医学 | 435篇 |
外科学 | 208723篇 |
综合类 | 31166篇 |
现状与发展 | 6篇 |
一般理论 | 436篇 |
预防医学 | 92168篇 |
眼科学 | 31441篇 |
药学 | 100341篇 |
4篇 | |
中国医学 | 3017篇 |
肿瘤学 | 75759篇 |
出版年
2018年 | 11838篇 |
2015年 | 11937篇 |
2014年 | 16804篇 |
2013年 | 25367篇 |
2012年 | 33177篇 |
2011年 | 35069篇 |
2010年 | 20852篇 |
2009年 | 20322篇 |
2008年 | 33724篇 |
2007年 | 36837篇 |
2006年 | 37390篇 |
2005年 | 36149篇 |
2004年 | 35176篇 |
2003年 | 34159篇 |
2002年 | 33656篇 |
2001年 | 63651篇 |
2000年 | 65362篇 |
1999年 | 55431篇 |
1998年 | 14674篇 |
1997年 | 13478篇 |
1996年 | 12955篇 |
1995年 | 12235篇 |
1994年 | 11484篇 |
1992年 | 42791篇 |
1991年 | 41316篇 |
1990年 | 40593篇 |
1989年 | 39576篇 |
1988年 | 36984篇 |
1987年 | 36423篇 |
1986年 | 34918篇 |
1985年 | 33115篇 |
1984年 | 24832篇 |
1983年 | 21061篇 |
1982年 | 12671篇 |
1981年 | 11580篇 |
1980年 | 10783篇 |
1979年 | 23938篇 |
1978年 | 17078篇 |
1977年 | 14840篇 |
1976年 | 13399篇 |
1975年 | 15276篇 |
1974年 | 18099篇 |
1973年 | 17575篇 |
1972年 | 16820篇 |
1971年 | 15729篇 |
1970年 | 14914篇 |
1969年 | 14353篇 |
1968年 | 13467篇 |
1967年 | 12019篇 |
1966年 | 11261篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
83.
Huda Mohammed Alkreathy Mayson H. Alkhatib Safaa Ahmed Al Musaddi Khadijah Saeed A. Balamash Nadia Nour Osman Aftab Ahmad 《Clinical and experimental pharmacology & physiology》2019,46(5):496-505
Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Nanoparticle drug delivery systems are a novel way of improving therapeutics and also improving the absorption and specificity of drugs towards tumour cells. In this study, we exploited this technology to increase drug specificity and minimize imminent adverse effects. In this study, the antitumour activity of the combination formulas of DOX and SIM, either loaded in water (DOX‐SIM‐Solution) or nanoemulsions (NEs) (DOX‐SIM‐NE), was evaluated in a Swiss albino mouse model of Ehrlich ascites carcinoma. The anticancer effect was assessed by quantifying the change in body weight, mean survival time, and percent increase in lifespan (%ILS), determining haematological and serum biochemical parameters (liver function test, kidney function test and lipid profile parameters) as well as studying the histopathological alterations in liver tissues. We observed a clear increase in %ILS of the DOX‐SIM‐Solution group (265.30) that was double the %ILS of the DOX‐SIM‐NE group (134.70). However, DOX‐SIM‐NE had a non‐toxic effect on the haematological parameters, whereas DOX‐SIM‐Solution increased the levels of haemoglobin and lymphocytes. Furthermore, the encapsulation of SIM and DOX into NEs improved the levels of all serum biochemical parameters compared to the DOX‐SIM‐Solution. A reduction in the side effects of DOX‐SIM‐NE on the liver was also established using light microscopy, which revealed that the morphologies of the hepatocytes of the mice were less affected by administration of the DOX‐SIM‐NE treatment than with the DOX‐SIM‐Solution treatment. The study showed that incorporating SIM into the DOX‐loaded‐NE formulation remarkably improved its efficiency and simultaneously reduced its adverse effects. 相似文献
84.
85.
Paola Gilsanz Maria M. Corrada Claudia H. Kawas Elizabeth Rose Mayeda M. Maria Glymour Charles P. Quesenberry Catherine Lee Rachel A. Whitmer 《Alzheimer's & dementia》2019,15(4):497-505
Introduction
Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence.Methods
Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life.Results
Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities.Discussion
Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude. 相似文献86.
87.
88.
89.
M.A. Mashrah T.A. Aldhohrah A. Abdelrehem Moustafa H.M. Al-Sharani A. Alrmali L. Wang 《International journal of oral and maxillofacial surgery》2021,50(1):21-31
Donor site morbidity following radial forearm flap (RFF) harvest remains a controversial issue. The aim of this meta-analysis was to answer the question “Are the range of wrist movements (range of motion, ROM) and hand strength affected after RFF harvesting?” The PubMed, Embase, Scopus, and Cochrane Library electronic databases were systematically searched (to December 2019). Self-controlled studies evaluating hand biomechanics after RFF harvest were included. Weighted mean differences with 95% confidence intervals were calculated using the random-effects model. The outcome variables were ROM, forearm movements, grip, and pinch strengths. Thirteen studies involving a total of 335 patients were included. With the exception of grip strength and supination, which showed statistically significant reductions of about 2.40 kg and 2.86° (P < 0.05), all other ROM, forearm movements, and pinch strengths showed an insignificant difference when the operated hand was compared to the non-operated hand (P > 0.05). Regression analysis showed that the method of donor site closure and size of the donor site defect had an insignificant impact on hand biomechanics. This study confirms the lack of discernible biomechanical morbidity after RFF transfer. The minimal reduction in hand biomechanics after RFF is considered to be clinically negligible. 相似文献