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151.
Aliye Ozenoglu Serdal Ugurlu Gunay Can Cihat Sarkis Yeltekin Demirel 《Central European Journal of Medicine》2010,5(6):724-732
Morbidity of obesity-related diseases tends to increase due to a rise in the body mass index (BMI). We aimed to investigate
how the body composition and biochemical parameters change while BMI increases in adult women were categorized as so: as normal
weight, overweight and obese. Our objectives are to study the effects of those changes in the development of metabolic disturbances
and to find out which parameters are the most sensitive to predict cardiometabolic risks. Three hundred and twenty two records
of adult women (mean age: 38.62±12.71 year) who admitted to our unit concerning about losing or preserving their weights,
were analyzed in the study. All patients had undergone anthropometric measurements and body composition analyses as well as
some biochemical tests. Body composition analyses were performed by means of the Bioelectrical Impedance Analyzer (BIA). Increase
in BMI significantly increased the body fat, blood sugar, insulin, triglyceride and uric acid levels. BMI and circumference
of the waist were significantly and negatively correlated with the ratio of body water and lean mass/fat mass. However they
were positively correlated with the ratio of fat mass and basal metabolism. Furthermore, it was also found that BMI and circumference
of the waist were significantly and positively correlated with level of fasting blood sugar, insulin, triglyceride, homeostasis
model assessment insulin resistance (HOMA-IR), uric acid and fibrinogen levels, and negatively correlated with high density
lipoprotein (HDL) cholesterol level. In multiple regression analyses, circumference of waist measurements was significantly
correlated with insulin, triglyseride and HDL, whereas the correlation between BMI and these parameters was not found significant.
Total body fat mass (as %) showed significant correlation only with HDL-C level. It could be said that obesity which is a
disorder that causes many health complications and affects the quality of life in the short and long term could be prevented
or cured by keeping negative environmental conditions under control. According to our results, visceral adipose tissue (VAT)
measurement was thought to be more related for metabolic and cardiovascular disorders rather than BMI. We also propose to
test fasting blood glucose, insulin, triglyceride, HDL, fibrinogen, homocystein (HOM) levels along with VAT measurements to
predict more truly about not only global cardiometabolic risk but also dementia in later life. 相似文献
152.
Ultrasonography has become accepted as a useful imaging modality in the early detection of developmental dysplasia of the
hip (DDH). The purpose of this study was to investigate the extent to which ultrasonographic measurements of femoral head
coverage correspond to the categories of hip maturity defined by Graf’s angle α. The infants in this study (1,037 infants,
2,034 hips) were examined as part of an ultrasound screening program for detecting DDH. We found that femoral head coverage
is positively correlated with α angle, and we also found upper and lower threshold values of femoral head coverage (51% and
39%), such that all hips having these values or beyond had mature or pathological development, respectively. For the detection
of hips having mature development, this provided a specificity of 100% (by definition) and a sensitivity of 82.6%. For hips
having pathological development, specificity was 100% and sensitivity was 79.2%.
Résumé L’échographie est une méthode permettant l’analyse et le dépistage des dysplasies de hanches (DDH). Le propos de cette étude est d’analyser la couverture de la tête fémorale, de déterminer si cette couverture permet de définir différentes catégories de maturité des hanches selon l’angle a de Graf. 1037 enfants (2034 hanches) ont été examinés par échographie dans un programme de dépistage de la luxation de hanche (DDH). Nous avons trouvé que la couverture de la tête fémorale était corrélée avec l’angle a de Graf. Nous avons pu déterminer des valeurs repères hautes et basses de couverture de la tête (51% et 39%), de telle sorte que les hanches qui sont soit dans ses valeurs soit en dehors de ces valeurs, ont un développement mature ou pathologique. La spécificité de ce dépistage est de 100% et la sensitivité de 82,6%. Pour les hanches pathologiques la spécificité est de 100% et la sensitivité de 79,2%.相似文献
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154.
Oznur Eyilcim Fulya Gunay Omer Tahir Gunkara Yuk Yin Ng Ozlem Ulucan Ihsan Erden 《Chemical biology & drug design》2023,102(5):1186-1201
A series of novel 1,2,3,4-tetrazines were designed and synthesized. 1H-NMR spectroscopy, 13C NMR spectroscopy, and HRMS were used to determine the structures of this novel compounds. Computational approaches suggested that DHFR is a putative target for the newly synthesized 11 compounds. Extensive molecular dynamics simulations followed by molecular docking simulations were employed to evaluate DHFR as a potential target protein. The anticancer activities of the compounds were evaluated against five different types of leukemia cell lines (Jurkat, Nalm-6, Reh, K562, and Molt-4) and one non-leukemic cell line (Hek293T) by MTT test in vitro and imatinib was used as a control drug. Among these compounds, 3a exhibited the best activity against all the leukemic cell lines, except Reh cell line. For Nalm-6, K562, Jurkat, and Molt-4 cell lines, IC50 values were found to be 15.98, 19.12, 23.15, and 25.80 μM, respectively. Our work focuses on the synthesis of original and novel 1,2,3,4-tetrazine derivatives while contributing to the ongoing effort to discover more potent new antileukemia agents. 相似文献
155.
Faiza Saleem Khalid Mohammed Khan Nisar Ullah Musa Özil Nimet Baltaş Shehryar Hameed Uzma Salar Abdul Wadood Ashfaq Ur Rehman Mukesh Kumar Muhammad Taha Syed Moazzam Haider 《Archiv der Pharmazie》2023,356(1):2200400
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α-amylase and α-glucosidase inhibitory as well as antioxidant activities. Pyridone derivatives 1–34 were synthesized via a one-pot multi-component reaction of variously substituted aromatic aldehydes, acetophenone, ethyl cyanoacetate, and ammonium acetate in absolute ethanol. Synthetic compounds 1–34 were structurally characterized by different spectroscopic techniques. Most of the tested compounds showed more promising inhibition potential than the standard acarbose (IC50 = 14.87 ± 0.16 µM) but compounds 13 and 12 were found to be the most potent compounds with IC50 values of 9.20 ± 0.14 µM and 3.05 ± 0.18 µM against α-amylase and α-glucosidase enzymes, respectively. Compounds 1–34 also displayed moderate antioxidant potential in the range of IC50 = 96.50 ± 0.45 to 189.98 ± 1.00 µM in comparison to the control butylated hydroxytoluene (BHT) (IC50 = 66.50 ± 0.36 µM), in DPPH radical scavenging activities. Additionally, all synthetic derivatives were subjected to a molecular docking study to investigate the interaction details of compounds 1–34 (ligands) with the active site of enzymes (receptors). These results indicate that the newly synthesized pyridone class may serve as promising lead candidates for controlling diabetes mellitus and as antioxidants. 相似文献
156.
157.
Jeffrey A. Zealley Dana Howard Courtney Thiele Joy Y. Balta 《Clinical anatomy (New York, N.Y.)》2022,35(1):19-25
Deceased human bodies are donated for education and research. Informed consent has become the standard for research on the living. A question could be asked on how informed are the donors and their families about the process before this generous gift is given. The aim of this study is to evaluate and compare the published donation forms used by body donation programs in the United States and assess them according to the guidelines published by the American Association of Clinical Anatomists. The findings of this study shows that the level of information given to donors and families, before consenting to whole body donation, varies greatly throughout the United States. Many of the forms fail to include the recommendations made by professional societies. Additional information needs to be added to whole body donation forms to better inform donors and families about the donation process, what happens to the body, and the final disposition of the bodies once studies are completed. Overall, it was concluded that in some cases consent is being obtained but much more needs to be done before institutions can claim to obtain informed consent. 相似文献
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