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141.
Sergio Nunes Pereira Izabelle Balta Zumba Micheline Sulzbacher Batista Daniela Da Pieve Elisandra dos Santos Ralf Stuermer Gerson Pereira de Oliveira Roberta Senger 《Brazilian Journal Of Cardiovascular Surgery》2015,30(4):433-442
Objective
This study aimed to compare the effects of two different perfusion techniques: conventional cardiopulmonary bypass and miniature cardiopulmonary bypass in patients undergoing cardiac surgery at the University Hospital of Santa Maria - RS.Methods
We perform a retrospective, cross-sectional study, based on data collected from the patients operated between 2010 and 2013. We analyzed the records of 242 patients divided into two groups: Group I: 149 patients undergoing cardiopulmonary bypass and Group II - 93 patients undergoing the miniature cardiopulmonary bypass.Results
The clinical profile of patients in the preoperative period was similar in the cardiopulmonary bypass and miniature cardiopulmonary bypass groups without significant differences, except in age, which was greater in the miniature cardiopulmonary bypass group. The perioperative data were significant of blood collected for autotransfusion, which were higher in the group with miniature cardiopulmonary bypass than the cardiopulmonary bypass and in transfusion of packed red blood cells, which was higher in cardiopulmonary bypass than in miniature cardiopulmonary bypass. In the immediate, first and second postoperative period the values of hematocrit and hemoglobin were higher and significant in miniature cardiopulmonary bypass than in the cardiopulmonary bypass, although the bleeding in the first and second postoperative days was higher and significant in miniature cardiopulmonary bypass than in the cardiopulmonary bypass.Conclusion
The present results suggest that the miniature cardiopulmonary bypass was beneficial in reducing the red blood cell transfusion during surgery and showed slight but significant increase in hematocrit and hemoglobin in the postoperative period. 相似文献142.
Ali Aktekin Nil Comunoglu Mehmet Odabasi Tolga Muftuoglu Gunay Gurleyik Gul Babacan Abanonu 《The Indian journal of surgery》2015,77(3):805-810
Only 49 % of diminutive colorectal polyps are neoplastic, but a tiny percentage contains advanced histology. We aimed to determine the rate of advanced diminutive polyps and to evaluate the influence of age, gender, number, and localization. Patients undergoing a videocolonoscopy in October 2010 and April 2012 were collected prospectively. Subjects with polyps ≤5 mm in diameter were recruited into the study. The presence of a villous component of >25 % and a high degree of dysplasia were categorized as polyps with advanced histology. Two hundred eight diminutive polyps were identified in 102 patients. Twenty (9.6 %) diminutive polyps in 13 (12.74 %) patients showed advanced histology. The probability of having an advanced diminutive polyp was higher in patients who have more than one polyp or have polyps localized all along the colon or only to the distal part (p?<?0.001 and p?=?0.002). Having more than one polyp increases the likelihood of having advanced diminutive polyp according to a multivariate analysis (p?=?0.003). Polyps accompanying any dysplastic diminutive polyp, being one of multiple polyps, and distributed all along the colon or localized to only the distal part have an increased probability of being an advanced diminutive polyp (p?<?0.001, p?=?0.047, p?<?0.001, and p?=?0.008). Multivariate logistic regression demonstrated that only any accompanying dysplastic diminutive polyp increases the probability of a polyp being advanced diminutive (p?=?0.034). Diminutive polyps could have advanced histology. Multiple polyps located in the whole colorectum or to the distal part or accompanying any advanced polyps may harbor an advanced histology and should be removed. 相似文献
143.
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Previous studies has report the modulation of K+ channels play key roles in the induction of peripheral antinociception induced by many types of drugs. However, the possible participation of 4-aminopyridine-sensitive K+ channels to local antinociception induced by tramadol, a mu opioid receptor agonist, and lidocaine, a local anaesthetic, has been less studied. In this study, we therefore investigated this by using thermal plantar test. Tramadol or lidocaine administered intraplantarly into the hind paw elicited an antinociceptive effect. 4-aminopyridine caused an increase in the antinociception produced by lidocaine. However, tramadol induced antinociception remained unaffected by intraplantar administration of 4-aminopyridine. These results suggest that 4-aminopyridine-sensitive K+ channels may play an important role in the thermal peripheral antinociception produced by lidocaine, but not tramadol. 相似文献
146.
Purpose Polymorphonuclear leucocytes (PML) play an essential role in the host immune response to severe infections. The effects of
granulocyte-colony stimulating factor (G-CSF) on the PML immune functions during serious abdominal infection and course of
sepsis, and on the survival in rats with peritonitis are the main subjects of this study.
Methods The first phase of the study was carried out on 30 Wistar-albino rats equally divided into three groups; Group 1 (control)
sham laparotomy; Group 2 (peritonitis); and Group 3 (peritonitis+G-CSF) with fecal peritonitis created by a cecal puncture.
At postoperative hours 3, 12, and 24, 0.5 ml normal saline was injected subcutaneously in groups 1 and 2, and 0.5 ml solution
containing 50 μg/kg of G-CSF in group 3. The phagocytic and chemotactic activities of neutrophils and monocytes were evaluated
by a flow cytometry analysis. The plasma lactate concentrations were assessed as a marker of tissue perfusion during sepsis.
The second phase was a survival analysis, which was observed during 10 days on 20 rats equally divided into two groups; group
1 (peritonitis) and group 2 (peritonitis+G-CSF). 0.5 ml normal saline in group 1 and 50 μg/kg of G-CSF in group 2 was injected
subcutaneously at the 3rd hour and twice daily.
Results Both the neutrophil- (1.636 vs 2.236) and monocyte-related (1.789 vs 2.465) phagocytic activities significantly (P < 0.001) improved after the G-CSF administration in the rats with peritonitis. In addition, the G-CSF treatment significantly
(P < 0.0014) improved the chemotactic activity (1.18 vs 2.75) of neutrophils, and partly supported (P < 0.0952) the chemotactic activity (1.69 vs 2.37) of monocytes. The plasma lactate level (1.86 vs 4.9 mmol/l) was significantly
(P < 0.0001) increased after septic changes due to experimental peritonitis. On the other hand, the lactate concentration was
significantly (P < 0.001) decreased (4.9 vs 2.63 mmol/l) after the G-CSF administration. The survival was 20% at the 4th day and 0 at the
6th day in peritonitis, and 90% at the 4th day (P = 0.0055) and 80% at the 6th day (P = 0.0007) days in the peritonitis+G-CSF groups.
Conclusion G-CSF enhances the immune functions of neutrophils and monocytes. The increased activities of these cells have a beneficial
effect on the enhancement of the host immune response during severe infections. The improved immune function of PML due to
the G-CSF treatment thus ameliorates the survival and the courses of sepsis, which is also defined by tissue perfusion and
the cellular oxygen balance, which is affected by septic changes. 相似文献
147.
Balta AZ Filiz AI Kurt Y Sucullu I Yucel E Akin ML 《Medical oncology (Northwood, London, England)》2012,29(2):734-741
The aim of this study was to evaluate the expressions of oncoproteins and to correlate the results with clinicopathologic
parameters in papillary thyroid carcinoma (PTC). Papillary thyroid cancer (PTC) is the most common form and accounts for about
80% of all thyroid cancers. Although PTC generally has a good prognosis, some patients suffer from local recurrence and/or
distant metastasis. Oncogenes have reported to be related not only in carcinogenesis but also in tumor prognosis, tumor type,
differentiation and site of tumor in epithelial malignant tumors such as thyroid, breast, ovarian, and stomach cancer. This
study was planned retrospectively and was performed in 87 patients (47 PTC, 40 benign lesions). The data of clinicopathologic
parameters and tissue samples were collected from the archives. Sections stained with H&E were evaluated for each case and
after confirming the diagnosis of PTC, oncoprotein expressions were determined by immunohistochemical analysis. The differences
of oncoprotein expressions in PTC compared with control group were statistically significant. Cyclin D1 and p53 expressions
were significantly increased in PTC. The expressions of bcl-2 and c-erbB-2 in PTC were found as increased, but the correlation
between these proteins and poor prognostic parameters were not significant. We suggest that increased expressions of cyclin
D1 and p53 could be used as prognostic factors in patients with PTC. 相似文献
148.
Aliye Ozenoglu Serdal Ugurlu Gunay Can Cihat Sarkis Yeltekin Demirel 《Central European Journal of Medicine》2010,5(6):724-732
Morbidity of obesity-related diseases tends to increase due to a rise in the body mass index (BMI). We aimed to investigate
how the body composition and biochemical parameters change while BMI increases in adult women were categorized as so: as normal
weight, overweight and obese. Our objectives are to study the effects of those changes in the development of metabolic disturbances
and to find out which parameters are the most sensitive to predict cardiometabolic risks. Three hundred and twenty two records
of adult women (mean age: 38.62±12.71 year) who admitted to our unit concerning about losing or preserving their weights,
were analyzed in the study. All patients had undergone anthropometric measurements and body composition analyses as well as
some biochemical tests. Body composition analyses were performed by means of the Bioelectrical Impedance Analyzer (BIA). Increase
in BMI significantly increased the body fat, blood sugar, insulin, triglyceride and uric acid levels. BMI and circumference
of the waist were significantly and negatively correlated with the ratio of body water and lean mass/fat mass. However they
were positively correlated with the ratio of fat mass and basal metabolism. Furthermore, it was also found that BMI and circumference
of the waist were significantly and positively correlated with level of fasting blood sugar, insulin, triglyceride, homeostasis
model assessment insulin resistance (HOMA-IR), uric acid and fibrinogen levels, and negatively correlated with high density
lipoprotein (HDL) cholesterol level. In multiple regression analyses, circumference of waist measurements was significantly
correlated with insulin, triglyseride and HDL, whereas the correlation between BMI and these parameters was not found significant.
Total body fat mass (as %) showed significant correlation only with HDL-C level. It could be said that obesity which is a
disorder that causes many health complications and affects the quality of life in the short and long term could be prevented
or cured by keeping negative environmental conditions under control. According to our results, visceral adipose tissue (VAT)
measurement was thought to be more related for metabolic and cardiovascular disorders rather than BMI. We also propose to
test fasting blood glucose, insulin, triglyceride, HDL, fibrinogen, homocystein (HOM) levels along with VAT measurements to
predict more truly about not only global cardiometabolic risk but also dementia in later life. 相似文献
149.
Ultrasonography has become accepted as a useful imaging modality in the early detection of developmental dysplasia of the
hip (DDH). The purpose of this study was to investigate the extent to which ultrasonographic measurements of femoral head
coverage correspond to the categories of hip maturity defined by Graf’s angle α. The infants in this study (1,037 infants,
2,034 hips) were examined as part of an ultrasound screening program for detecting DDH. We found that femoral head coverage
is positively correlated with α angle, and we also found upper and lower threshold values of femoral head coverage (51% and
39%), such that all hips having these values or beyond had mature or pathological development, respectively. For the detection
of hips having mature development, this provided a specificity of 100% (by definition) and a sensitivity of 82.6%. For hips
having pathological development, specificity was 100% and sensitivity was 79.2%.
Résumé L’échographie est une méthode permettant l’analyse et le dépistage des dysplasies de hanches (DDH). Le propos de cette étude est d’analyser la couverture de la tête fémorale, de déterminer si cette couverture permet de définir différentes catégories de maturité des hanches selon l’angle a de Graf. 1037 enfants (2034 hanches) ont été examinés par échographie dans un programme de dépistage de la luxation de hanche (DDH). Nous avons trouvé que la couverture de la tête fémorale était corrélée avec l’angle a de Graf. Nous avons pu déterminer des valeurs repères hautes et basses de couverture de la tête (51% et 39%), de telle sorte que les hanches qui sont soit dans ses valeurs soit en dehors de ces valeurs, ont un développement mature ou pathologique. La spécificité de ce dépistage est de 100% et la sensitivité de 82,6%. Pour les hanches pathologiques la spécificité est de 100% et la sensitivité de 79,2%.相似文献
150.