全文获取类型
收费全文 | 11556篇 |
免费 | 502篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 267篇 |
儿科学 | 497篇 |
妇产科学 | 401篇 |
基础医学 | 1034篇 |
口腔科学 | 414篇 |
临床医学 | 960篇 |
内科学 | 2696篇 |
皮肤病学 | 205篇 |
神经病学 | 713篇 |
特种医学 | 514篇 |
外科学 | 2301篇 |
综合类 | 254篇 |
一般理论 | 3篇 |
预防医学 | 465篇 |
眼科学 | 251篇 |
药学 | 634篇 |
中国医学 | 36篇 |
肿瘤学 | 496篇 |
出版年
2024年 | 8篇 |
2023年 | 108篇 |
2022年 | 232篇 |
2021年 | 393篇 |
2020年 | 209篇 |
2019年 | 278篇 |
2018年 | 331篇 |
2017年 | 242篇 |
2016年 | 382篇 |
2015年 | 432篇 |
2014年 | 542篇 |
2013年 | 622篇 |
2012年 | 802篇 |
2011年 | 813篇 |
2010年 | 483篇 |
2009年 | 424篇 |
2008年 | 788篇 |
2007年 | 890篇 |
2006年 | 880篇 |
2005年 | 812篇 |
2004年 | 686篇 |
2003年 | 550篇 |
2002年 | 483篇 |
2001年 | 86篇 |
2000年 | 82篇 |
1999年 | 69篇 |
1998年 | 60篇 |
1997年 | 43篇 |
1996年 | 53篇 |
1995年 | 29篇 |
1994年 | 21篇 |
1993年 | 22篇 |
1992年 | 24篇 |
1991年 | 20篇 |
1990年 | 24篇 |
1989年 | 31篇 |
1988年 | 20篇 |
1987年 | 19篇 |
1986年 | 18篇 |
1985年 | 18篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1982年 | 6篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1974年 | 5篇 |
1973年 | 9篇 |
1972年 | 7篇 |
1971年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
N M Elsayed A D Hacker K Kuehn M G Mustafa G N Schrauzer 《Toxicology and applied pharmacology》1983,71(3):398-406
We examined the influence of dietary selenium (Se) on the pulmonary biochemical response to ozone (O3) exposure. For 11 weeks, weanling female strain A/St mice were fed a test diet containing Se either at 0 ppm (-Se) or 1 ppm (+Se). Each diet contained 55 ppm vitamin E (vit E). Mice from each dietary group were exposed to 0.8 +/- 0.05 ppm (1568 +/- 98 micrograms/m3) O3 continuously for 5 days. After O3 exposure, they were killed along with a matched number of unexposed controls, and their lungs were analyzed for various biochemical parameters. The Se contents of lung tissue and whole blood were determined, and the levels were seven- to eightfold higher in +Se mice than in -Se mice, reflecting the Se intake of the animals. In unexposed control mice, Se deficiency caused a decline in glutathione peroxidase (GP) activity relative to +Se group. After O3 exposure, the GP activity in the -Se group was associated with a lack of stimulation of glutathione reductase (GR) activity and the pentose phosphate cycle (PPC) as assessed by measuring glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) activities. In contrast, the +Se group after O3 exposure exhibited increases in all four enzyme activities. Other parameters, e.g., lung weight, total lung protein, DNA and nonprotein sulfhydryl contents, and O2 consumption, were not affected by dietary Se in the presence or absence of O3 exposure. The data indicate that dietary Se alters the GP activity, which in turn influences the GR and PPC activities in the lung evidently through a reduced demand for NADPH. The level of vit E in the lung was found to be twofold higher in the -Se group than in the +Se group, suggesting a compensatory relationship between Se and vit E in the lung. With O3 exposure, both Se and vit E contents further increased in the lungs of each dietary group. It is plausible that Se and vit E under oxidant stress are "mobilized" to the lung from other body sites. 相似文献
42.
The validity of the Cognitive Coping Strategy Inventory (CCSI; Butler et al., 1989) was tested in a prospective fashion. Subjects were randomly assigned to one of three conditions. Some were matched to a strategy for which they received a high CCSI score, some were mismatched to a strategy for which they received a low CCSI score, and some were given a choice of strategies. Those subjects using a matched strategy obtained better threshold and tolerance times on the cold pressor than subjects who used a mismatched strategy. Despite clear differences in exposure to the cold pressor these conditions did not differ from each other in self-reported levels of pain. It was concluded that the CCSI appears to be a valid and useful tool for selecting a coping strategy to help particular individuals manage acute pain. Though the CCSI is relatively easy to administer and score, the comparative costs and benefits of using it must be weighed against the somewhat more efficient approach of simply offering the subject a choice of treatments. Subjects given a choice of strategies performed as well as subjects matched to a strategy on the basis of CCSI scores. 相似文献
43.
Fumihiko Kawamoto Nobuo Kido Takamasa Hanaichi Mustafa B. A. Djamgoz Robert E. Sinden 《Parasitology research》1992,78(4):277-284
Ionic regulation in the induction of exflagellation ofPlasmodium berghei was investigated by culturing the parasites in various isotonic media. Of the salts tested, NaHCO3 exhibited the highest activity in inducing exflagellation, whereas KHCO3 showed no activity. In the absence of HCO
3
–
, media containing monovalent cation (Na+, K+, Cs+, Rd+, choline+, lysine+, arginine+) and Cl– also induced exflagellation, but their activities were lower than that of NaHCO3. Anions of Br– or NO
3
–
could be substituted with Cl–, whereas other anions such as I–, NO
2
–
, SO
4
2–
, SCN–, H2PO
4
–
, or HPO
4
2–
failed to induce exflagellation, as did tetramethylammonium-Cl, CaCl2, MgSO4, MgCl2 and sucrose as well. These results suggest that the induction of exflagellation requires the presence of Na+ and HCO
3
–
or monovalent, membrane-permeable cation and Cl– in the medium. Measurements of the efflux of H[14C]O
3
–
or Cl– indicated that these anions were released from the cells into the NaCl or the NaHCO3 medium, respectively, probably by exchange in HCO
3
–
/Cl–. Determination of intracellular ionic concentrations by electron microscopic X-ray microanalysis of cryopreserved specimens revealed that in the NaHCO3 medium, external Na+ (and probably HCO
3
–
) enters the gametocytes by exchange with internal Cl– (and probably H+), whereas in Cl–-containing media, external unspecified cation and Cl– influx by exchange, probably with H+ and HCO
3
–
. It is therefore suggested that two separate ion exchangers, i.e., Na+-dependent HCO
3
–
(in)/Cl–(out) and nonspecific monovalent-cation-dependent Cl–(in)/HCO
3
–
(out) exchangers, are involved in the induction of gametogenesis inP. berghei. Furthermore, the presence of both classes of anion in the medium enhanced exflagellation activity and increased Na+ uptake more than did the NaCl or NaHCO3 medium alone. The apparent synergistic enhancement by two contraactive anion exchangers is consistent with a recycling model of pHi regulation, in which HCO
3
–
and Cl– are exchanged between the cells and the media, resulting in the acceleration of monovalent cation/H+ exchange.This work was supported by a Grant-in-Aid (No. 01570212) from the Ministry of Education, Science and Culture, Japan and the Ohyama Health Foundation, Japan (to FK), and in part by the Medical Research Council, United Kingdom (to RES) 相似文献
44.
45.
Mustafa Cengiz Cem Onal Ferah Yildiz A Faruk Zorlu 《Radiotherapy and oncology》2004,73(1):109; author reply 109-109; author reply 110
46.
The trouble with kidneys derived from the non heart-beating donor: a single center 10-year experience 总被引:3,自引:0,他引:3
Balupuri S Buckley P Snowden C Mustafa M Sen B Griffiths P Hannon M Manas D Kirby J Talbot D 《Transplantation》2000,69(5):842-846
BACKGROUND: The demand for renal transplantation has increasingly outstripped the supply of donor organs especially over the past 10 years. Although related and unrelated live donation is being promoted as one option for increasing the donor pool, it is unlikely that this will in itself be able to bridge the gap. Non-heart beating donors (NHBD) can provide an alternative supply of organs, which should substantially increase the donor pool. METHODS: In Newcastle, NHBD kidneys have been used for transplantation for a period of 10 years. In the early period (1988-1993) excellent results were obtained (90.5% success); however, these donors were controlled NHBD, Maastricht category III. In the second phase (1994-1998) increasing numbers of donors were obtained from the Accident and Emergency Department unit. These were failed resuscitation for cardiac arrest (category II). The rates of success in this period were poor (45.5% success) and the program was halted. The third phase of the program used machine perfusion of the kidneys and glutathione S transferase enzyme analysis to assess viability. RESULTS: Using such approaches renal transplants from largely category II donors produced a success rate of 92.3% which was significantly better than the phase II period of the program (P=0.023, Fisher two-tail test). CONCLUSION: Machine perfusion and viability assessment of NHB kidneys in phase III of the program has increased our donor pool as well as improved the graft survival. This is particularly relevant for the use of the category II NHB donor where the incidence of primary nonfunction was high, illustrated by phase II where machine perfusion/viability assessment was not used. 相似文献
47.
Yesim Cetinkaya Sardan Pinar Zarakolu Belgin Altun Aycan Yildirim Gonul Yildirim Gulsen Hascelik Omrum Uzun 《Infection control and hospital epidemiology》2004,25(10):878-882
BACKGROUND: On February 19, 2003, four patients (patients 1-4) in the neurology ward underwent cranial magnetic resonance angiography (MRA) and developed fever within 1 hour afterward. Klebsiella oxytoca was isolated from blood cultures of patients 1 through 3. OBJECTIVE: To identify the source of this cluster of nosocomial K. oxytoca bloodstream infections. DESIGN: Outbreak investigation. SETTING: A 1,000-bed university hospital. METHODS: The infection control team reviewed patient charts and interviewed nursing staff about the preparation and administration of parenteral fluids. The procedure of cranial MRA was observed. Arbitrarily primed polymerase chain reaction (AP-PCR) was performed to show the clonal relationship among these three strains. RESULTS: AP-PCR revealed that three K. oxytoca isolates had the same molecular profile. Cranial MRA was found to be the only common source among these patients. During MRA, before injection of the contrast medium, normal saline solution was infused to check the functioning of the intravenous catheter. Use of the solution for multiple patients was routine, but the access diaphragm of the bottle was not cleansed. The bottle of normal saline solution used on February 19 had already been discarded and the culture sample taken from the solution on the day of observation was sterile. CONCLUSIONS: We speculate that normal saline solution became contaminated during manipulation and that successive uses might have been responsible for this cluster. Poor aseptic techniques employed during successive uses appear to be the most likely route of contamination. Use of parenteral solutions for multiple patients was discontinued. 相似文献
48.
49.
Segmental myoclonus is described as the involuntary contractions of contiguous muscles innerved by the brain stem or by spinal cord. The underlying causes of segmental myoclonus in children are demyelinating diseases and intrinsic tumors. Here, we report a case who was presented with segmental myoclonus on his left arm and later diagnosed as atypical monosymptomatic presentation of acute disseminated encephalomyelitis (ADEM). The case represents the first in the literature in which ADEM is considered as the possible cause of segmental myoclonus. Our findings demonstrate that: (i) in focal movement disorders such as segmental myoclonus, a careful neuroradiological examination of the neuroanatomical region for the possible presence of organic lesions might be rewarding, (ii) ADEM might be one of the potentially reversible causes of myoclonus. 相似文献
50.
Ugur Selek Mustafa Cengiz Gokhan Ozyigit Ferah Yildiz Ibtisam Lale Atahan 《Radiotherapy and oncology》2005,76(1):107-8; author reply 108