全文获取类型
收费全文 | 701篇 |
免费 | 56篇 |
国内免费 | 96篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 35篇 |
妇产科学 | 1篇 |
基础医学 | 89篇 |
口腔科学 | 20篇 |
临床医学 | 113篇 |
内科学 | 167篇 |
皮肤病学 | 18篇 |
神经病学 | 26篇 |
特种医学 | 109篇 |
外科学 | 34篇 |
综合类 | 36篇 |
预防医学 | 30篇 |
眼科学 | 18篇 |
药学 | 83篇 |
肿瘤学 | 70篇 |
出版年
2023年 | 3篇 |
2021年 | 8篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 11篇 |
2013年 | 27篇 |
2012年 | 15篇 |
2011年 | 13篇 |
2010年 | 34篇 |
2009年 | 25篇 |
2008年 | 19篇 |
2007年 | 67篇 |
2006年 | 24篇 |
2005年 | 33篇 |
2004年 | 11篇 |
2003年 | 11篇 |
2002年 | 18篇 |
2001年 | 17篇 |
2000年 | 15篇 |
1999年 | 13篇 |
1998年 | 42篇 |
1997年 | 38篇 |
1996年 | 31篇 |
1995年 | 29篇 |
1994年 | 29篇 |
1993年 | 41篇 |
1992年 | 9篇 |
1991年 | 12篇 |
1990年 | 13篇 |
1989年 | 30篇 |
1988年 | 27篇 |
1987年 | 21篇 |
1986年 | 18篇 |
1985年 | 18篇 |
1984年 | 17篇 |
1983年 | 4篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 12篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 10篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 2篇 |
排序方式: 共有853条查询结果,搜索用时 78 毫秒
51.
Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementia.
Dean C Delis Spencer R Wetter Mark W Jacobson Guerry Peavy Joanne Hamilton Assawin Gongvatana Joel H Kramer Mark W Bondi Jody Corey-Bloom David P Salmon 《Journal of the International Neuropsychological Society》2005,11(6):708-715
Memory tests that are in a recall format have almost universally measured accuracy in terms of the number of target items reported by the examinee. However, this traditional scoring method can, in certain cases, result in artificially inflated memory accuracy scores. That is, just as a "yes" response bias and high false-positive rate on recognition testing can artificially inflate a patient's hit rate, so, too, a liberal response bias and high intrusion rate on recall testing can artificially inflate a patient's level of target recall. Recognition tests correct for this problem by using a discriminability measure that provides a single score of hit rate relative to false-positive rate; however, recall tests rarely provide a single score of recall accuracy that corrects for intrusion rate. In the present study, we examined the utility of a new recall discriminability measure that analyzes target recall relative to intrusion rate. Patients with Alzheimer's disease (AD) or Huntington's disease (HD) were administered the CVLT-II, which provides both the traditional measure of target recall and a new measure of recall discriminability. The results indicate that the new recall discriminability measure was superior to the traditional level of target recall measure in distinguishing the recall performance of AD and HD patients. Implications of these results for clinical practice and theories of memory disorder in dementia are discussed. 相似文献
52.
An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction 总被引:1,自引:0,他引:1
Mulhall JP Bukofzer S Edmonds AL George M;Apomorphine SL Study Group 《Clinical therapeutics》2001,23(8):1260-1271
BACKGROUND: Because apomorphine is a dopamine agonist that acts on areas of the central nervous system believed to mediate penile erection, its use in erectile dysfunction (ED) has been investigated. However, it also produces nausea by dopamine-receptor stimulation of the chemotrigger zone in the brain. Therefore, a low plasma concentration, achieved rapidly, would be selective for the desired erectile response but would be below the dopamine threshold for nausea. OBJECTIVE: We evaluated the efficacy and tolerability of a dose-optimized regimen of a sublingual formulation of apomorphine (apomorphine SL) in the treatment of ED. METHODS: This was a multicenter, open-label, uncontrolled, Phase III dose-optimization study of apomorphine SL in heterosexual men with ED. The 2-week screening period, during which baseline severity of ED was determined using the International Index of Erectile Function, was followed by a 3-week dose-optimization period beginning at a dose of 2 mg. Patients were to make at least 2 attempts at intercourse per week throughout the study, placing 1 apomorphine tablet under the tongue beforehand. At the end of the first week, the dose could be increased to 3 mg at the discretion of the investigator; at the end of the second week, the dose could be increased to a maximum of 4 mg or decreased as needed. In the following 4-week treatment period, patients took their individual optimal doses. The primary efficacy variable was the percentage of attempts resulting in erections firm enough for intercourse, as assessed by investigators' review of data from patients' diaries. Secondary variables included the percentage of attempts resulting in successful intercourse, time to erection, and duration of erection. Information about adverse events, including their severity and relation to treatment, was determined on the basis of direct questioning, spontaneous reports, and review of patient diaries. RESULTS: The study enrolled 849 heterosexual men whose ages ranged from 31 to 78 years (mean, 58.1 years). They had a mean 5.7-year history of ED of varbus causes. ED was mild in 11.5% of the men, moderate in 23.8 c, and severe in 48.1%. When results of the last 8 attempts were pooled, representing the period during which patients were taking their optimal doses of apomorphine SL, the mean percentage of attempts resulting in erections firm enough for intercourse was 39.4%, compared with 13.1% at baseline; attempts resulting in intercourse increased from a mean of 12.7% at baseline to 38.3% with treatment. The average median time to erection was 23 minutes, and the average median duration of erection was 13 minutes. Nausea, the most common treatment-related adverse event (11.7%). was dose related and diminished with continued dosing. One patient had a single syncopal episode that was judged to be related to apomorphine SL. CONCLUSIONS: In the present study, a dose-optimization regimen of apomorphine SL-with dosing initiated at 2 mg and adjusted up to a maximum of 4 mg as needed-was effective and well tolerated in the treatment of ED, regardless of its cause or severity. 相似文献
53.
Background: An outbreak of food poisoning in a military establishment mess was investigated and remedial measures suggested. 相似文献
54.
高效液相色谱法测定寒痹停片中士的宁含量 总被引:6,自引:0,他引:6
目的:建立用HPLC测定寒痹停片中士的含量的方法。方法:氰基柱;流动相-甲醇-水-三乙胺-乙酸(9800:155:15:30);紫外检测波长254nm。结果:在4~20ug/ml范围内,标准曲线回归方程为:Y=-2803+8967x(r=0.9997),RSD=1.65%?加样回收率的平均值为99.82%。结论:实验表明,这是一个适用于生产控制和产品质量检验的简单、快速、准确的方法。 相似文献
55.
Control of apoptosis in Epstein Barr virus-positive nasopharyngeal carcinoma cells: opposite effects of CD95 and CD40 stimulation 总被引:3,自引:0,他引:3
Sbih-Lammali F Clausse B Ardila-Osorio H Guerry R Talbot M Havouis S Ferradini L Bosq J Tursz T Busson P 《Cancer research》1999,59(4):924-930
The expression and function of CD95 and CD40 were investigated in malignant cells from EBV-positive undifferentiated nasopharyngeal carcinomas (NPCs). Large amounts of CD95 and CD40 expression were detected in 15 of 16 EBV-positive NPC specimens. In contrast, CD95 was not detected in two biopsies from patients with EBV-negative differentiated NPCs. We tested whether the CD95 apoptotic pathway was functional in NPC cells by treating two EBV-positive NPC tumor lines in vitro with a CD95 agonist. In both cases, NPC cells were extremely susceptible to CD95-mediated apoptosis, despite strong constitutive expression of Bcl-x. Combined CD40 and CD95 stimulation was used to investigate the possible anti-apoptotic activity mediated by CD40. The CD40 receptor was activated by incubating NPC cells with murine L cells producing CD154, the CD40 ligand. This treatment resulted in a strong inhibition of CD95-related cytotoxicity. Such an anti-apoptotic effect of CD40 is well known for B lymphocytes, but has not previously been reported for epithelial cells. These data suggest that NPC tumor-infiltrating lymphocytes, which often produce the CD40 ligand in situ, may increase the survival of malignant cells, thereby enhancing tumor growth in patients. 相似文献
56.
57.
58.
59.
60.
When inferior vena caval obstruction complicates the Budd-Chiari syndrome, conventional portosystemic shunts are not possible. The mesoatrial shunt has been devised to enable portal and sinusoidal decompression in these patients. Findings in 12 patients with Budd-Chiari syndrome and inferior vena caval obstruction in whom a mesoatrial shunt was performed are reported. Preoperative inferior vena cavography with pressure measurements is essential to determine the appropriate shunt procedure. Postoperatively, shunt patency is assessed with superior mesenteric arterial portography. Where possible, transvenous catheterization of the shunt is performed to confirm patency and assess hemodynamic function. 相似文献