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991.
992.
A-M McIntyre MA PhD S Macgregor MSC MRPharms M Malek MSC PhD JA Dunbar MD FRCGP JG Hamley MSC MRPharmS JA Cromarty MSC MRPharmS 《International journal of clinical practice》1997,51(5):276-281
Fifty-seven patients newly presenting to their GP with dyspepsia agreed to take part in a pharmacist-led clinic which tested and treated for Helicobacter pylori. Of these patients, 63% (36/57) tested positive and received eradication therapy. For 78% (28/36), eradication was successful with the first course of treatment, 89% (25/28) remaining symptom-free over the six-month follow-up. Eradication was successful for a further 17% (6/36) after a second attempt; again, these patients remained free of symptoms over the follow-up period. Thus, of the initial patients, 54% (31/57) were successfully treated, with no further symptoms. Such results had significant consequences on the expected direct cost of management per patient from a GP viewpoint. Using decision analysis it was found that H. pylori eradication for patients presenting with dyspepsia for the first time could result in considerable cost savings per patient in the long term. 相似文献
993.
van der Meer M; de Boer JA; Hompes PG; Schoemaker J 《Human reproduction (Oxford, England)》1998,13(6):1465-1469
The aim of the present study was to determine the effect of octreotide, a
somatostatin analogue, on ovarian sensitivity for follicle stimulating
hormone (FSH) in patients with polycystic ovary syndrome (PCOS). As the
measure of ovarian sensitivity, the FSH threshold was determined in a
case-control set-up. Eleven patients with PCOS were treated with FSH in a
low dose step-up manner and subsequently received treatment with FSH
combined with octreotide. The FSH threshold was found to be significantly
higher during combined treatment. This increase was associated with a
decrease in insulin-like growth factor-I (IGF-I) and IGF binding protein-3
(IGFBP-3) concentrations during treatment with octreotide, but not with a
decrease in insulin concentrations. No differences were found between the
two regimens, in number of follicles, in oestradiol concentrations on the
day of human chorionic gonadotrophin (HCG) administration or in ovulation
rate. With both treatments, there was a very low rate of multifollicular
development. It can be concluded that octreotide lowers ovarian sensitivity
for FSH through suppression of IGF-I/IGFBP-3 in patients with PCOS.
However, this does not appear to affect follicular development during
gonadotrophin stimulation, because the latter is controlled to a high
degree by the use of a low dose step-up treatment schedule in these
patients.
相似文献
994.
Craig JG; Amin MB; Wu K; Eyler WR; van Holsbeeck MT; Bouffard JA; Shirazi K 《Radiology》1997,203(3):849
995.
MR Gandhi JA Andersen B Coyne D Richardson 《Journal of Medical Imaging and Radiation Oncology》1995,39(1):66-67
This case describes some unusual computed tomography findings in a patient with an acute ascending cholangitis and pancreatitis due to a calculus impacted in the distal common bile duct. 相似文献
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