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排序方式: 共有230条查询结果,搜索用时 15 毫秒
81.
FOXP3 mutations causing early‐onset insulin‐requiring diabetes but without other features of immune dysregulation,polyendocrinopathy, enteropathy,X‐linked syndrome 下载免费PDF全文
82.
Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins Ib and IIb-IIIa 总被引:12,自引:7,他引:12
Different types of platelets in various types of plasma were subjected to levels of shear stress that produce irreversible platelet aggregation in normal platelet-rich plasma (PRP). At shear stresses of 90 or 180 dyne/cm2 applied for 30 seconds or five minutes, aggregation was either absent or only transient and reversible using severe von Willebrand's disease (vWD) PRP (less than 1% von Willebrand factor, vWF); Bernard-Soulier syndrome (BSS) PRP (platelets deficient in the membrane glycoprotein Ib, GPIb); normal PRP plus monoclonal antibody (MoAb) to GPIb; thrombasthenic PRP (platelets deficient in membrane glycoprotein IIb-IIIa complex, GPIIb-IIIa); and normal PRP plus MoAb to GPIIb-IIIa. Shear-induced aggregation was inhibited under the above conditions, even though the platelets were activated to release their granular contents. Sheared normal platelets in vWD plasma aggregated in response to added vWF. These studies demonstrate that the formation of stable platelet aggregates under conditions of high shear requires vWF and the availability of both GPIb and GPIIb-IIIa on platelet membranes. The experiments demonstrate that vWF-platelet interactions can occur in the absence of artificial agonists or chemical modification of vWF. They suggest a possible mechanism for platelet aggregation in stenosed or partially obstructed arterial vessels in which the platelets are subjected to relatively high levels of shear stress. 相似文献
83.
Accurate arterial blood pressure measurement is crucial in order to provide safe and appropriate care to patients in both theatre and the intensive care setting. Blood pressure is a measure of haemodynamic status and stability. This article will review the physical principles of both non-invasive and invasive methods of blood pressure measurement. We will cover historical measurement, commonly used techniques in clinical practice and more recent developments in blood pressure monitoring. 相似文献
84.
85.
Rotator cuff sonography: a reassessment 总被引:4,自引:0,他引:4
This study is both a retrospective and prospective evaluation of the clinical usefulness of shoulder sonography. Ninety-eight patients suspected of having rotator cuff tears underwent sonography of both shoulders. Sixty-two patients underwent double-contrast arthrography performed on the same day as sonography, and 38 patients underwent surgery after sonography. A comparison of the results from ultrasound and arthrography, using published diagnostic criteria, demonstrated a sensitivity of 75% and a specificity of 43% for detection of a rotator cuff tear. In this study, use of more restricted criteria, a subset of the published criteria, yielded a sensitivity of 68% and a specificity of 90%. A comparison of sonography with surgery, using this study's criteria, demonstrated a sensitivity of 57% and a specificity of 76%. This report shows that shoulder sonography is less reliable than previously reported and appears to have a very limited role in the evaluation of rotator cuff injuries. 相似文献
86.
Organization of intrinsic connections in owl monkey area MT 总被引:3,自引:1,他引:2
Malach R; Schirman TD; Harel M; Tootell RB; Malonek D 《Cerebral cortex (New York, N.Y. : 1991)》1997,7(4):386-393
Area MT (middle temporal) is a well-defined visual representation common to
all primates, which shows a clear selectivity to the analysis of visual
motion. In the present study we examined the architecture of the intrinsic
connections in area MT in an attempt to reveal its organizing principles
and its potential relationship to the functional domains in area MT.
Intrinsic connections were studied by placing small injections of the
tracer biocytin in area MT of seven adult owl monkeys (Aotus nancymae). The
injections were targeted at well-defined orientation domains revealed using
optical imaging of intrinsic signals. The distribution of axons labeled by
these injections was related both to the cytochrome oxidase histochemistry
and to the layout of functional domains in area MT and surrounding tissue.
Tracer injections in the superficial layers of area MT produced a complex
network of extrinsic and intrinsic axonal connections. Clear instances of
extrinsic connections were observed between area MT proper and the MT
crescent situated postero-medially to it. The intrinsic connections were
laterally spread and organized in patch-like clusters with an average
distance from injection center to the furthest patch of 1.8 +/- 0.55 mm
(+/-SD, n = 9). The overall axonal distribution tended to be anisotropic,
i.e. the patches were distributed within an elongated ellipse [average
anisotropy ratio: 1.86 +/- 0.66 (+/-SD)] and were asymmetrically
distributed about either side of the injection site [average asymmetry
ratio: 2.3 +/- 0.7 (+/-SD)]. Finally, there was a tendency for the
intrinsic connections to connect to functional domains of similar
orientation preference in area MT. However, this tendency varied
substantially between individual cases. The highly specific nature of MT
lateral connections puts clear constraints on models of surround influences
in the receptive fields of MT neurons.
相似文献
87.
4-S-(5-酰氨基-1,3,4-噻二唑-2-基)-4-脱氧-4′-去甲基表鬼臼毒素衍生物的合成与抗肿瘤活性 总被引:3,自引:0,他引:3
基于在4′-去甲基表鬼臼毒素母核C4位上联结含有杂原子的芳香环取代基,以此考察其结构与活性关系的设想,设计并合成了10个标题化合物。体外L1210白血病细胞与KB细胞生长抑制试验结果表明,这类化合物有较强的抗肿瘤活性。其中化合物SIPI-92-1772,1774,1775,1776,1777与1779的活性超过临床用药依托泊甙。其余化合物活性与依托泊甙相当或略低。 相似文献
88.
Jennifer L. Sherr Julia M. Hermann Fiona Campbell Nicole C. Foster Sabine E. Hofer Jeremy Allgrove David M. Maahs Thomas M. Kapellen Naomi Holman William V. Tamborlane Reinhard W. Holl Roy W. Beck Justin T. Warner for the TD Exchange Clinic Network the DPV Initiative and the National Paediatric Diabetes Audit the Royal College of Paediatrics Child Health registries 《Diabetologia》2016,59(1):87-91
89.
Therapeutic inertia: underdiagnosed and undertreated hypertension in children participating in the T1D Exchange Clinic Registry 下载免费PDF全文
90.