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排序方式: 共有158条查询结果,搜索用时 15 毫秒
71.
Sonal Asthana Suryanarayana VS Deo Nootan K Shukla Vinod Raina 《Journal of Medical Imaging and Radiation Oncology》2001,45(3):380-382
Metastases to the peripheral bones of the extremities are rare. Such lesions are often diagnosed as inflammatory or infective in nature. We present a report of a case of simultaneous involvement of the peripheral bones of the extremities – the talus and the thumb of the left hand – with a brief review of pathophysiology and management. 相似文献
72.
Background
A total of 31 cases of effects of high altitude were admitted to a field hospital from a particular sector during the year 2008. This study was hence undertaken to see the efficacy of acclimatisation as well as outline the determinants of acclimatisation. Methods: The study monitored the transients in the acclimatisation period as well as laid down the guidelines to certify their fitness after the acclimatisation period.Result
Almost 4.70% of transients were found unfit to proceed to higher altitudes even after acclimatisation. Tachycardia with oxygen saturation below 90% by digital pulse oximetry were the parameters found to be statistically significant as an indicator to declare a person as not fully acclimatised or otherwise.Conclusion
The administrative authorities must ensure that an individual is fully acclimatized, based on the fitness certificates issued, before being dispatched to their units located in high altitude areas.Key Words: Acclimatisation, Pulse oximetry, High altitude area 相似文献73.
Gregersen N; Winter VS; Corydon MJ; Corydon TJ; Rinaldo P; Ribes A; Martinez G; Bennett MJ; Vianey-Saban C; Bhala A; Hale DE; Lehnert W; Kmoch S; Roig M; Riudor E; Eiberg H; Andresen BS; Bross P; Bolund LA; Kolvraa S 《Human molecular genetics》1998,7(4):619-627
We have shown previously that a variant allele of the short-chain acyl- CoA
dehydrogenase ( SCAD ) gene, 625G-->A, is present in homozygous form in
7% of control individuals and in 60% of 135 patients with elevated urinary
excretion of ethylmalonic acid (EMA). We have now characterized three
disease-causing mutations (confirmed by lack of enzyme activity after
expression in COS-7 cells) and a new susceptibility variant in the SCAD
gene of two patients with SCAD deficiency, and investigated their frequency
in patients with elevated EMA excretion. The first SCAD-deficient patient
was a compound heterozygote for two mutations, 274G-->T and 529T-->C.
These mutations were not present in 98 normal control alleles, but the
529T-->C mutation was found in one allele among 133 patients with
elevated EMA excretion. The second patient carried a 1147C-->T mutation
and the 625G- ->A polymorphism in one allele, and a single point
mutation, 511C-->T, in the other. The 1147C-->T mutation was not
present in 98 normal alleles, but was detected in three alleles of 133
patients with elevated EMA excretion, consistently as a 625A-1147T allele.
On the other hand, the 511C-->T mutation was present in 13 of 130 and 15
of 67 625G alleles, respectively, of normal controls and patients with
elevated EMA excretion, and was never associated with the 625A variant
allele. This over-representation of the haplotype 511T-625G among the
common 625G alleles in patients compared with controls was significant ( P
< 0.02), suggesting that the allele 511T-625G-like 511C-625A- confers
susceptibility to ethylmalonic aciduria. Expression of the variant R147W
SCAD protein, encoded by the 511T-625G allele, in COS-7 cells showed 45%
activity at 37 degrees C in comparison with the wild- type protein,
comparable levels of activity at 26 degrees C, and 13% activity when
incubated at 41 degrees C. This temperature profile is different from that
observed for the variant G185S SCAD protein, encoded by the 511C-625A
allele, where higher than normal activity was found at 26 and 37 degrees C,
and 58% activity was present at 41 degrees C. These results corroborate the
notion that the 511C-625A variant allele is one of the possible underlying
causes of ethylmalonic aciduria, and suggest that the 511C-->T mutation
represents a second susceptibility variation in the SCAD gene. We conclude
that ethylmalonic aciduria, a commonly detected biochemical phenotype, is a
complex multifactorial/polygenic condition where, in addition to the
emerging role of SCAD susceptibility alleles, other genetic and
environmental factors are involved.
相似文献
74.
M Welker J Salanitri VS Deshpande SM Shea D Li FS Pereles 《Journal of Medical Imaging and Radiation Oncology》2006,50(2):114-121
Coronary artery anomalies are uncommon entities that may be associated with sudden death. Because of its 2‐D projection imaging nature, conventional X‐ray coronary angiography may not accurately delineate the origins and course of aberrant coronary arteries with respect to the great vessels. Non‐invasive, cross‐sectional imaging techniques such as coronary CT angiography and magnetic resonance angiography are increasingly used in clinical practice to diagnose coronary artery anomalies. Although this study reviews coronary artery anatomy and selected anomalies as seen with true fast imaging with steady‐state precession magnetic resonance angiography, the information provided is equally applicable to electrocardiogram‐gated coronary CT angiography. 相似文献
75.
76.
VS Rotenberg P Indurski R Kimhi J Hadjez Y Gutman E Shamir Y Barak A Elizur 《International journal of psychiatry in clinical practice》2013,17(1):63-67
AIM: Few investigations of sleep structure in schizophrenia have concentrated on the relationship between objective and subjective sleep variables. The aim of this study was to assess objective sleep variables and subjective estimation of sleep duration and sleep quality. METHODS: Polysomnography was performed in 20 chronic patients with schizophrenia during three consecutive nights. After final awakenings subjects answered questions concerning subjective estimations of sleep duration, sleep latency, number of awakenings, and sleep depth. Pearson correlations between ranged subjective reports and objective sleep variables were performed. RESULTS: The results showed a high positive correlation between objective sleep latency and its subjective estimation; a positive correlation between subjective estimation of sleep depth and percentage of slow wave sleep (SWS%); a positive correlation between eye movement (EM) density and subjective estimation of wakefulness during the night; and a negative correlation between EM density and dream reports. CONCLUSION: We concluded that objective sleep variables are related to subjective sleep estimation in schizophrenic patients. In these patients, EM activity in REM sleep is related to the subjective feeling of wakefulness. (Int J Psych Clin Pract 2000; 4:63-67) 相似文献
77.
Ramshekhar Menon VS Lekha Sunitha Justus P Sankara Sarma PS Mathuranath 《Annals of Indian Academy of Neurology》2014,17(4):420-425
Aims:
This pilot study sought to determine whether the Malayalam adaptation of Addenbrooke''s Cognitive Examination (M-ACE) can effectively identify patients with amnestic mild cognitive impairment (a-MCI) and the impact of measures of learning and free recall.Materials and Methods:
A cohort of 23 patients with a-MCI aged between 55-80 years diagnosed as per current criteria and 23 group matched cognitively normal healthy controls (CNHC) were studied. The measures of acquisition and delayed recall were the Rey Auditory Verbal Learning Test (RAVLT) and Wechsler Memory Scale (WMS)-III (verbal and visual subsets) and Delayed Matching-to-sample Test (DMS)-48. Test scores of M-ACE registration and recall scores were included. To examine the differences in test performances between the groups, we compared the number of subjects with test scores less than 1.5 standard deviation (SD) of the control scores. Comparisons between a-MCI and controls were drawn using Fisher''s exact test and Mann-Whitney U tests.Results:
M-ACE registration component ascertained on a 24-point scale failed to demonstrate any differences between a-MCI and controls (P = 0.665) as opposed to recall judged on a cumulative 10-point scale (P = 0.001). Significant differences were noted in RAVLT list learning (P < 0.001) and list recall (P = 0.003), WMS-III paragraph learning (P <0.001) and recall (P = 0.007), visual learning (P = 0.004) and recall (P = 0.001).Conclusions:
M-ACE recall scores are an effective screening tool to identify patients with suspected a-MCI. Both word list and paragraph learning and recall components have been found to be sensitive to concretely identify a-MCI and impairment on at least 2 tests should be considered in the diagnostic criteria of MCI rather than rely on a single screening battery. 相似文献78.
SH Subba VS Binu RG Menezes J Ninan MS Rana 《Indian Journal of Community Medicine》2011,36(2):128-132
Background:
Smokeless tobacco is found to be as addictive and harmful as smoking but have not been explored into, especially among youth.Objectives:
This study was conducted to find the prevalence of tobacco chewing among college students in Nepal and the factors that have influence over their use.Study design:
A cross-sectional study with a self-administered questionnaire.Materials and Methods:
Five colleges of different streams in Pokhara city were selected for the study. A total of 816 students participated. The study was conducted during the period of May 2006–February 2007, using a semi-structured, self-administered questionnaire.Results:
Overall prevalence of ever tobacco chewing was 21.3% (males 30.2% and females 10.9%) among the youth with average age of initiation 15.7 years. Pan masala and gutka were used by 63.6% and frequency of use varied widely and only 5.7% said they were daily users. Reasons cited for chewing were most commonly ‘just like it’ or ‘friends chew’. Multiple logistic regression analysis showed age, ever smoking status, being ever alcoholic, and having friends or family members who chewed were significantly associated with students’ tobacco chewing. Almost one-tenth of the students believed they were addicted to chewing tobacco and 42.5% of them had tried to quit the habit.Conclusion:
The study shows a high prevalence of tobacco chewing by Nepali youth. Important factors that influenced the habit were having chewer friends, their own smoking and alcohol status and having family members who chewed. It is pertinent to consider these when formulating cessation and prevention programs 相似文献79.
Kennedy DN; Lange N; Makris N; Bates J; Meyer J; Caviness VS Jr 《Cerebral cortex (New York, N.Y. : 1991)》1998,8(4):372-384
This magnetic resonance imaging (MRI)-based morphometric analysis of
cortical topography in the human brain is based upon the segmentation and
parcellation of volumetric T1-weighted MRI data for a set of 20 young adult
brains including 10 males and 10 females. For the most part, each
parcellation unit (PU) of the neocortex corresponds to a single or a
portion of a single gyrus. The volumes of each PU were computed for each
brain. Subsets of PUs were also grouped so as to represent the neocortex
for the frontal, temporal, parietal and occipital lobes. The coefficient of
variation of the mean volume of total neocortex and that of the neocortex
assigned to individual lobes cluster around 10%, whereas that of neocortex
assigned to the individual gyri (PU) is more than twice that value.
Approximately 80% of the total variance in gyral volume arises from
determinants interactive for individual and specific gyri, while only
approximately 10% of the total variance appears to be a reflection of
uniform scaling to total neocortical volume. Sexual dimorphism contributes
a pervasive though relatively small component of this variance. These
results have implications for the study of structure-function correlation,
and the proper statistical methods of handling volumetric data in
morphometric studies. In addition, the nature of the covariance structure
of the data will lead to future hypotheses regarding the relationships
between the various potential genetic and epigenetic gyral influencing
factors.
相似文献
80.