Der infizierte rheumatische Vorfuß—wie viel Chirurgie ist sinnvoll?

A biomechanically altered rheumatic forefoot with a resulting shoe conflict and an impaired immune system due to underlying disease and medical treatment are often cause for infection. Often infected bursae perforate into the corresponding joints and may consequently lead to severe infectious states of the foot. The multiplicity of possible biomechanical adjustments makes it difficult to develop an undisputed concept. Conservative versus operative therapeutic options are possible and may be individually applied. It should be questioned, if the same general rules in septic joint surgery also apply to the rheumatoid forefoot. This retrospective clinical study will evaluate a concept for possible operative treatment of the infected rheumatoid forefoot in selected cases. Our conception advocates operative procedures on a patient adapted basis in order to prevent recurrent infections. Suggestions for operative procedures are given.     

Disorders of humoral immunity in hypertension

Examination included 51 patients with essential hypertension (EH) of an uncomplicated course, labile (IB-IIA stage, according to A. L. Myasnikov's classification) and stable (IIB stage) hypertension. Clinical characteristics were given to the stages and duration of EH, body weight of the patients, arterial hypertension (AH) heredity and the AP level. Immunological examination included determination of the concentration of the basic classes of immunoglobulins IgG, IgA, IgM, circulating immune complexes (CIC), concentration of IgE and beta 2-microglobulins. It was revealed that EH development is attended by an increased concentration of immunoglobulins, primarily of IgA (23 per cent), IgE (31 per cent) and CIC (21 per cent), which is associated, to a certain degree, with a factor of AH hereditary aggravation.     

Die transtrochantäre ventrale Rotationsosteotomie bei der Behandlung der idiopathischen Hüftkopfnekrose

Zusammenfassung Das Operationsverfahren nachSugioka erm?glicht es, durch Rotation des Femurkopfes um die Schenkelhalsachse nach vorne den Nekrosebezirk aus der Belastungszone zu bringen. An Hand eigener Erfahrungen mit dieser Methode bei 9 Patienten werden Operationstechnik, Rotationsausma?, Nachbehandlung und Komplikationen besprochen. Auf Grund der befriedigenden Frühergebnisse wird auf diese japanische Methode aufmerksam gemacht.

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Summary Sugioka's operative procedure allows an anterior rotation of the femoral head upon the axis of the neck. Necrosis gets out of the weight-bearing area. We discuss the operative technique, angle of rotation, aftertreatment, and complications of 9 patients. According to the good early results we present this Japanese method.

     

The extract of Mucuna pruriens possesses histamine activity

ObjectiveTo investigate the activity of the active principle in the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity.MethodsThe active principle was extracted with 0.0015 M NaCl. Muscle strips of guinea pig ileum were prepared and contractile responses were measured using a Kymograph. Two sets of experiment were conducted: (1). The contraction of the ileum in presence of different concentrations of histamine, 2-methylhistamine and the extract of Mucuna pruriens. (2). The contractile response of the ileum in presence of different concentrations of the extract and antagonists including diphenhydramine, atropine and methysergide.Results(1) The extract of Mucuna pruriens hair, 2-methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED₅₀ = 13.0 μg/mL, 2-methylhistamine ED₅₀ = 8.5 μg/mL and histamine ED₅₀ = 10.0 μg/mL). (2) Diphenhydramine, an H₁ antagonist competitively blocked the contractile response of the Mucuna pruriens extract. (3) Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ileum.ConclusionThese results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.     

Hematological profile of pregnant women in southwest of Nigeria

ObjectiveTo evaluate the values of some major hematological parameters at different trimesters of pregnancy.MethodsThe research involved 33 healthy pregnant women as the study group and 11 non-pregnant women as control. The age range of these women was 20-40 years. Ethical approval was obtained from Olabisi Onabanjo University Teaching Hospital, Sagamu. Three milliliters of venous blood collected from the median cubital vein with minimum stasis were put into K⁺EDTA bottle. The blood was properly mixed and analyzed for packed cell volume (PCV), total white cell count, differential counts and erythrocyte sedimentation rate (ESR). Hematology was done according to standard methods.ResultsThe result showed that study group exhibited statistically significant lower values of PCV, monocyte and lymphocyte while WBC, eosinophil and ESR were not significantly changed. There was no significant difference in all hematological parameters among the three trimesters.ConclusionsHealthy pregnancy may have effect on hematological parameters. Therefore, there is a need to monitor these parameters during pregnancy. We also find that stages of pregnancy have no influence on hematological parameters.