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981.
Intramammary arterial calcifications associated with diabetes 总被引:3,自引:0,他引:3
982.
Characterization of survival motor neuron (SMNT) gene deletions in asymptomatic carriers of spinal muscular atrophy 总被引:14,自引:1,他引:13
Wang CH; Xu J; Carter TA; Ross BM; Dominski MK; Bellcross CA; Penchaszadeh GK; Munsat TL; Gilliam TC 《Human molecular genetics》1996,5(3):359-365
Previous reports have established that the telomeric copy of the survival
motor neuron (SMNT) gene and the intact copy of the neuronal apoptosis
inhibitory protein (NAIP) gene are preferentially deleted in patients with
spinal muscular atrophy (SMA). Although deletions or mutations in the SMNT
gene are most highly correlated with SMA, it is not clear to what extent
NAIP or other genes influence the SMA phenotype, or whether a small
fraction of SMA patients actually have functional copies of both SMNT and
NAIP. To evaluate further the part of SMNT in the development of SMA, we
analyzed 280 asymptomatic SMA family members for the presence or absence of
SMNT exons 7 and 8. We report the following observations: (i) 4% of the
sample harbored a polymorphic variant of SMNT exon 7 that looks like a
homozygous deletion; (ii) approximately 1% of the parents are homozygously
deleted for both exons 7 and 8; (iii) one asymptomatic parent lacking both
copies of SMNT exons 7 and 8 displays a 'subclinical phenotype'
characterized by mild neurogenic pathology; (iv) another asymptomatic
parent lacking both SMNT exons showed no signs of motor neuron disorder by
clinical and neurodiagnostic analyses. The demonstration of polymorphic
variants of exon 7 that masquerade as homozygous nulls, and the
identification of SMA parents who harbor two disease alleles, serve as a
caution to those conducting prenatal tests with these markers.
相似文献
983.
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985.
LC Turner CA Molgaard CH Gardner JF Rothrock PE Stang 《Cephalalgia : an international journal of headache》1995,15(6):523-530
We conducted an investigation of migraine headache in a general population of Mexican-Americans living in San Diego county. Specific headache triggers were reported and analyzed, the most frequently reported for females with migraine being missing meals (58.9%), weather changes (54.4%), menstruation (53.6%), post-crisis letdown (52.7%), and fatigue (51.8%). The most frequently reported trigger factors for migraines reported by males were fatigue (58.8%), sleep (as a precipitating factor) (56.3%), post-crisis letdown (41.2%), and weather changes (37.5%). Trigger factors were further evaluated using stratification by presence or absence of Raynaud's phenomenon (RP), menstrual migraine, family history of migraine, and by migraine type. Odds ratios and 95% confidence intervals were calculated. These results suggest that subjects with migraine and RP (perhaps indicative of a systematic vascular tone disorder) and those with menstrual migraine (indicative of sensitivity to hormonal changes) may overall be more sensitive to certain environmental stimuli, particularly those involving change in the internal environment. 相似文献
986.
987.
2-Thiothiazolidine-4-carboxylic acid (TTCA) was measured in urine of two persons given an oral dose of 250 mg disulfiram. Maximum concentrations up to 0.33 mmol creatinine were found, 10 to 14 h after dosing. The total amounts of TTCA excreted in urine were 1.8 and 3.5 μmol, respectively, which correspond to 0.2 and 0.41% of the dose. 相似文献
988.
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990.
With the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected separately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe. 相似文献