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排序方式: 共有848条查询结果,搜索用时 531 毫秒
141.
Del Mar O'Callaghan M Emperador S López-Gallardo E Jou C Buján N Montero R Garcia-Cazorla A Gonzaga D Ferrer I Briones P Ruiz-Pesini E Pineda M Artuch R Montoya J 《Neurogenetics》2012,13(3):245-250
The reported cases showed clinical, biochemical, histopathological, and molecular features lending support to the hypothesis of a pathogenic effect of the detected mutations. Case 1 was a neonatal presentation who showed multiple mitochondrial respiratory chain enzyme defects in muscle associated with a new homoplasmic m.5514A > G transition in the tRNA(Trp) gene. Case 2 was a late infantile presentation who also showed mitochondrial respiratory chain enzyme deficiencies in muscle together with a new m.1643A > G tRNA(Val) mutation in homoplasmy. Case 3 showed a MERRF phenotype presented in childhood associated with the once previously reported m.15923A > G mutation in heteroplasmy in all the tissues studied. 相似文献
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Formulation,stability study and preclinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis 下载免费PDF全文
Lígia de Souza Fernandes Yuri Martins Amorim Elton Libério da Silva Samuel Calixto Silva Alécia Junia Aparecida Santos Franciele Natália Peixoto Luara Moniele Neves Pires Raquel Yumi Sakamoto Flávia do Carmo Horta Pinto Maria Virgínia Costa Scarpa Marcelo Gonzaga de Freitas Araújo 《Mycoses》2018,61(10):723-730
Owing to the growing resistance among isolates of Candida species to usual antifungal agents and the well‐known therapeutic potential of curcumin, the purpose of this study was to develop and validate a vaginal formulation containing this substance and to evaluating its effectiveness in the treatment of experimental vulvovaginal candidiasis. Curcumin was incorporated in a vaginal cream in three concentrations (0.01%, 0.1% and 1.0%). The different concentrations of the cream and its controls were intravaginally administered in an immunosuppressed rat model to evaluate the efficacy in the treatment of experimental vulvovaginal candidiasis. Samples of the cream were also subjected to centrifugation and physical stability tests and an analytical method for quantification of curcumin was validated based on HPLC. The formulation was stable and the HPLC method could be considered suitable for the quantitative determination of curcumin in the cream. After 6 days of preclinical study, the number of infected animals was 1/6 in all groups treated with curcumin vaginal cream and the fungal burden showed a progressive reduction. Reduction in the inflammatory infiltrate was observed in the group treated with 1.0% cream. Vaginal cream containing curcumin could be considered a promising effective antifungal medicine in the treatment of vulvovaginal candidiasis. 相似文献
147.
Karina Bezerra Salomão Gustavo Alencastro Veiga Cruzeiro Ricardo Bonfim-Silva Lenisa Geron Fernando Ramalho Fabiano Pinto Saggioro Luciano Neder Serafini Daniel Antunes Moreno Rosane Gomes de Paula Queiroz Simone dos Santos Aguiar Izilda Cardinalli José Andres Yunes Silvia Regina Brandalise Maria Sol Brassesco Carlos Alberto Scrideli Luiz Gonzaga Tone 《Journal of neuro-oncology》2018,136(1):33-39
Immune cells of myeloid origin, including microglia, macrophages, and myeloid-derived suppressor cells adopt immunosuppressive phenotypes that support gliomagenesis. Here, we tested an a priori hypothesis that single nucleotide polymorphisms (SNPs) in genes related to glioma-associated myeloid cell regulation and function are also associated with patient survival after glioma diagnosis. Subjects for this study were 992 glioma patients treated at The University of Texas MD Anderson Cancer Center in Houston, Texas between 1992 and 2008. Haplotype-tagging SNPs in 91 myeloid-associated genes were analyzed for association with survival by Cox regression. Individual SNP- and gene-based tests were performed separately in glioblastoma (WHO grade IV, n?=?511) and lower-grade glioma (WHO grade II–III, n?=?481) groups. After adjustment for multiple testing, no myeloid-associated gene variants were significantly associated with survival in glioblastoma. Two SNPs, rs147960238 in CD163 (p?=?2.2?×?10?5) and rs17138945 in MET (p?=?5.6?×?10?5) were significantly associated with survival of patients with lower-grade glioma. However, these associations were not confirmed in an independent analysis of 563 lower-grade glioma cases from the University of California at San Francisco Adult Glioma Study (p?=?0.65 and p?=?0.41, respectively). The results of this study do not support a role for inherited polymorphisms in myeloid-associated genes in affecting survival of patients diagnosed with glioblastoma or lower-grade glioma. 相似文献
148.
Profile of cell proliferation and apoptosis activated by the intrinsic and extrinsic pathways in the prostate of aging rats 下载免费PDF全文
149.
Augusto Faria Andrade Kleiton Silva Borges Veridiana Kiill Suazo Lenisa Geron Carolina Alves Pereira Corrêa Angel Mauricio Castro-Gamero Elton José Rosas de Vasconcelos Ricardo Santos de Oliveira Luciano Neder José Andres Yunes Simone dos Santos Aguiar Carlos Alberto Scrideli Luiz Gonzaga Tone 《Investigational new drugs》2017,35(1):124-124
150.
Resistant hypertension and hyperaldosteronism 总被引:1,自引:0,他引:1
Resistant hypertension is defined as blood pressure that remains uncontrolled in spite of ≥ 3 antihypertensive medications
at effective doses, ideally including a diuretic. Although exact prevalence is unknown, clinical trials suggest that 20% to
30% of study participants are resistant. Hyperaldosteronism, obesity, refractory volume expansion, and obstructive sleep apnea
are common findings in resistant hypertension patients. Multiple studies indicate that primary aldosteronism (PA) is common
(∼ 20%) in patients with resistant hypertension. Screening for PA is recommended for most patients with resistant hypertension,
ideally by measurement of 24-hour urinary aldosterone excretion, or by the plasma aldosterone/plasma renin activity ratio.
Successful treatment of resistant hypertension is predicated on improvement of lifestyle factors; accurate diagnosis and treatment
of secondary causes of hypertension; and use of effective multidrug regimens. A long-acting diuretic, specifically chlorthalidone,
is recommended as part of the treatment regimen. Recent studies demonstrate that mineralocorticoid receptor antagonists provide
substantial antihypertensive benefit when added to multidrug regimens, even in patients without demonstrable aldosterone excess. 相似文献