全文获取类型
收费全文 | 3697篇 |
免费 | 238篇 |
国内免费 | 78篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 223篇 |
妇产科学 | 42篇 |
基础医学 | 431篇 |
口腔科学 | 250篇 |
临床医学 | 402篇 |
内科学 | 779篇 |
皮肤病学 | 120篇 |
神经病学 | 277篇 |
特种医学 | 446篇 |
外科学 | 262篇 |
综合类 | 72篇 |
一般理论 | 3篇 |
预防医学 | 172篇 |
眼科学 | 26篇 |
药学 | 247篇 |
2篇 | |
中国医学 | 1篇 |
肿瘤学 | 255篇 |
出版年
2021年 | 28篇 |
2019年 | 34篇 |
2018年 | 53篇 |
2017年 | 38篇 |
2016年 | 33篇 |
2015年 | 49篇 |
2014年 | 60篇 |
2013年 | 89篇 |
2012年 | 74篇 |
2011年 | 89篇 |
2010年 | 121篇 |
2009年 | 117篇 |
2008年 | 96篇 |
2007年 | 133篇 |
2006年 | 122篇 |
2005年 | 114篇 |
2004年 | 76篇 |
2003年 | 79篇 |
2002年 | 69篇 |
2001年 | 84篇 |
2000年 | 77篇 |
1999年 | 82篇 |
1998年 | 148篇 |
1997年 | 170篇 |
1996年 | 147篇 |
1995年 | 126篇 |
1994年 | 124篇 |
1993年 | 113篇 |
1992年 | 88篇 |
1991年 | 88篇 |
1990年 | 80篇 |
1989年 | 88篇 |
1988年 | 94篇 |
1987年 | 87篇 |
1986年 | 115篇 |
1985年 | 101篇 |
1984年 | 77篇 |
1983年 | 46篇 |
1982年 | 50篇 |
1981年 | 52篇 |
1980年 | 48篇 |
1979年 | 42篇 |
1978年 | 31篇 |
1977年 | 38篇 |
1976年 | 46篇 |
1975年 | 34篇 |
1973年 | 36篇 |
1972年 | 25篇 |
1971年 | 23篇 |
1970年 | 32篇 |
排序方式: 共有4013条查询结果,搜索用时 0 毫秒
991.
Dorine CM Collard Mai JM Chinapaw Evert ALM Verhagen Willem van Mechelen 《BMC pediatrics》2010,10(1):86
Background
In general, only information regarding the effectiveness of an intervention programme is ever published. However, in recent years evaluating the translatability and feasibility of an intervention programme has become more important. Therefore, this paper presents the results of the evaluation of the iPlay programme aimed at preventing physical activity related injuries in primary school children. 相似文献992.
Berna DL Broekhuizen Alfred PE Sachs Arno W Hoes Karel GM Moons Jan WK van den Berg Willem H Dalinghaus Ernst Lammers Theo JM Verheij 《The British journal of general practice》2010,60(576):489-494
Background
Chronic obstructive pulmonary disease (COPD) and asthma are underdiagnosed in primary care.Aim
To determine how often COPD or asthma are present in middle-aged and older patients who consult their GP for persistent cough.Design of study
A cross-sectional study in 353 patients older than 50 years, visiting their GP for persistent cough and not known to have COPD or asthma.Setting
General practice in the Netherlands.Method
All participants underwent extensive diagnostic work-up, including symptoms, signs, spirometry, and body plethysmography. All results were studied by an expert panel to diagnose or exclude COPD and/or asthma. The reproducibility of the panel diagnosis was assessed by calculation of Cohen''s κ statistic in a sample of 41 participants.Results
Of the 353 participants, 102 (29%, 95% confidence interval [CI] = 24 to 34%) were diagnosed with COPD. In 14 of these 102 participants, both COPD and asthma were diagnosed (4%, 95% CI = 2 to 7%). Asthma (without COPD) was diagnosed in 23 (7%, 95% CI = 4 to 10%) participants. Mean duration of cough was 93 days (median 40 days). The reproducibility of the expert panel was good (Cohen''s κ = 0.90).Conclusion
In patients aged over 50 years who consult their GP for persistent cough, undetected COPD or asthma is frequently present. 相似文献993.
994.
Further work on the use of albumin in the intensive care unit is discussed. The interesting pilot study by Dubois and colleagues examines the potential benefits for albumin supplementation in the hypoalbuminaemic critically ill patient. Maintaining the fluid theme, we discuss recent work on factors influencing post-intensive care unit blood transfusion as well as another study on erythropoietin. Finally, a large multicentred trial comparing continuous venovenous haemofiltration with intermittent haemodialysis is outlined, the results of which pose more questions than answers. 相似文献
995.
996.
997.
M-J Castro AH Stam C Lemos B de Vries KRJ Vanmolkot J Barros GM Terwindt RR Frants J Sequeiros MD Ferrari JM Pereira-Monteiro & AMJM van den Maagdenberg 《Cephalalgia : an international journal of headache》2009,29(3):308-313
Almost all mutations in the SCN1A gene, encoding the α1 subunit of neuronal voltage-gated NaV 1.1 sodium channels, are associated with severe childhood epilepsy. Recently, two mutations were identified in patients with pure familial hemiplegic migraine (FHM). Here, we identified a novel SCN1A L263V mutation in a Portuguese family with partly co-segregating hemiplegic migraine and epilepsy. The L263V mutation segregated in five FHM patients, three of whom also had epileptic attacks, occurring independently from their hemiplegic migraine attacks. L263V is the first SCN1A mutation associated with FHM and co-occurring epilepsy in multiple mutation carriers, and is the clearest molecular link between migraine and epilepsy thus far. The results extend the clinical spectrum associated with SCN1A mutations and further strengthen the molecular evidence that FHM and epilepsy share, at least in part, similar molecular pathways. 相似文献
998.
A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2) 总被引:13,自引:5,他引:8
Serratosa JM; Gomez-Garre P; Gallardo ME; Anta B; de Bernabe DB; Lindhout D; Augustijn PB; Tassinari CA; Malafosse RM; Topcu M; Grid D; Dravet C; Berkovic SF; de Cordoba SR 《Human molecular genetics》1999,8(2):345-352
Progressive myoclonus epilepsy of the Lafora type or Lafora disease (EPM2;
McKusick no. 254780) is an autosomal recessive disorder characterized by
epilepsy, myoclonus, progressive neurological deterioration and
glycogen-like intracellular inclusion bodies (Lafora bodies). A gene for
EPM2 previously has been mapped to chromosome 6q23- q25 using linkage
analysis and homozygosity mapping. Here we report the positional cloning of
the 6q EPM2 gene. A microdeletion within the EPM2 critical region, present
inhomozygosis in an affected individual, was found to disrupt a novel gene
encoding a putative protein tyrosine phosphatase (PTPase). The gene,
denoted EPM2, presents alternative splicing in the 5' and 3' end regions.
Mutational analysis revealed that EPM2 patients are homozygous for
loss-of-function mutations in EPM2. These findings suggest that Lafora
disease results from the mutational inactivation of a PTPase activity that
may be important in the control of glycogen metabolism.
相似文献
999.
JM Wilmshurst NH Thomas RO Robinson JB Bingham KRE Pohl 《Acta paediatrica (Oslo, Norway : 1992)》2001,90(6):691-703
This study assesses the frequency of lower limb and back pain in children with Guillain-Barré syndrome and reviews the magnetic resonance imaging results of those undergoing spinal imaging. Over an 8-y period, nine children presented with various combinations of severe back pain, leg pains, impairment of gait and bladder dysfunction. Guillain-Barré syndrome was confirmed on clinical examination and peripheral electrophysiology ( n = 8). Magnetic resonance imaging in four patients, following contrast injection, showed enhancement of the cauda equine and, additionally, of the cervical nerve roots in one of the patients. A further patient, who was not scanned with contrast, had abnormal thickening of the lumbar roots. Carbamazepine and steroids were effectively used for analgesia in three cases. All the patients recovered.
Conclusion: Guillain-Barré syndrome should be considered in the differential diagnosis of children presenting with back and/or leg pain. Early diagnosis ensures prompt monitoring for autonomic dysfunction and respiratory compromise. 相似文献
Conclusion: Guillain-Barré syndrome should be considered in the differential diagnosis of children presenting with back and/or leg pain. Early diagnosis ensures prompt monitoring for autonomic dysfunction and respiratory compromise. 相似文献
1000.