全文获取类型
收费全文 | 562篇 |
免费 | 61篇 |
专业分类
儿科学 | 6篇 |
妇产科学 | 3篇 |
基础医学 | 30篇 |
临床医学 | 28篇 |
内科学 | 456篇 |
皮肤病学 | 16篇 |
神经病学 | 21篇 |
特种医学 | 2篇 |
外科学 | 31篇 |
综合类 | 5篇 |
预防医学 | 9篇 |
眼科学 | 1篇 |
药学 | 11篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 14篇 |
2018年 | 6篇 |
2017年 | 9篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 13篇 |
2013年 | 17篇 |
2012年 | 37篇 |
2011年 | 57篇 |
2010年 | 14篇 |
2009年 | 13篇 |
2008年 | 43篇 |
2007年 | 45篇 |
2006年 | 35篇 |
2005年 | 42篇 |
2004年 | 21篇 |
2003年 | 24篇 |
2002年 | 15篇 |
2001年 | 15篇 |
2000年 | 30篇 |
1999年 | 19篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 6篇 |
1992年 | 22篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有623条查询结果,搜索用时 15 毫秒
531.
Rahman P Sun S Peddle L Snelgrove T Melay W Greenwood C Gladman D 《Arthritis and rheumatism》2006,54(7):2321-2325
OBJECTIVE: The interleukin-1 (IL-1) cytokine elicits a wide variety of biologic activities that initiate and promote an inflammatory response. The loci in the IL1 gene cluster have recently been associated with ankylosing spondylitis (AS). Since there is clinical and immunologic overlap between psoriatic arthritis (PsA) and AS, we wanted to examine the association between a panel of single-nucleotide polymorphisms (SNPs) in the IL1 gene family cluster and chromosome 2q12-13 in a PsA cohort. METHODS: Two hundred twelve PsA patients and 150 ethnically matched controls were genotyped with 11 SNPs in IL1A, 9 SNPs in IL1B, and 9 SNPs in IL1F5-10. Univariate analyses of the 29 single markers and short intragenic haplotypes identified several associated regions. Seventeen markers of interest were noted and further investigated to determine which markers or short haplotypes independently predict case-control status, using a stepwise logistic model. RESULTS; Two regions contributing independently to risk of disease in PsA were noted: a region spanned by markers rs3783547, rs3783543, and rs17561 in IL1A, and a region near the end of IL1B, through IL1F7, IL1F8, and into IL1F10. The best model contained markers rs3811047, rs1562304, and rs3811058, and 1 haplotype constructed from the 3 markers in region 1, with a likelihood ratio of 25.34 (4 degrees of freedom). CONCLUSION: The IL1 locus appears to be a high-priority susceptibility locus in PsA, with at least 2 independent regions that confer increased risk. 相似文献
532.
G Gladman 《The Australasian medical journal》2011,4(6):308-314
Background
Doctors undertaking vocational training in general practice in Australia may require assistance, in addition to the normal training offered as part of their training programme. Issues requiring assistance may go undetected for a period of time. Delay in the identification of issues leads to delay in the provision of the assistance. The aim of this study is to determine the most common reasons registrars require extra assistance, and how these issues are identified. The findings of this study will provide direction for 21 regionally based training providers (RTPs) to develop improved tools to ensure earlier detection of registrars requiring assistance.Method
This study is based on qualitative research methods, using semi-structured interviews with senior medical education staff of four regional general practice training providers in Victoria, Australia.Results
Issues identified included language and cultural issues, applied knowledge and skills, attitude and professionalism, and health and family issues.The principal method that training providers identified issues was via the GP supervisor. This was predominantly by informal communication, rather than formal evaluation sheets. Other methods included the external clinical teaching visit and other training formative assessments. These more formalised procedures were more likely to identify issues later than desired. They were also used as a way of clarifying suspected problems. The selection process was not felt to be helpful, and the examinations provided information too late.Conclusion
An increased awareness of the potential issues leading to a registrar to require assistance enables identification and subsequent action to occur in a more timely and more useful fashion. Informal communication between practices and training programme staff should be encouraged to enable these issues to be dealt with early in training. 相似文献533.
Pollock R Chandran V Barrett J Eder L Pellett F Yao C Lino M Shanmugarajah S Farewell VT Gladman DD 《Tissue antigens》2011,77(6):554-561
About 30% of patients with psoriasis have psoriatic arthritis (PsA), an inflammatory arthritis that can affect both axial and peripheral joints. Major histocompatibility complex class I chain-related A (MICA) alleles have previously been shown to be associated with PsA; however it is unclear whether there is a differential association of MICA alleles with skin and joint manifestations of PsA. Here, we describe a case-control study that aims to validate previously reported MICA allele associations with PsA and determine whether MICA alleles differentiate patients with PsA from those with psoriasis without PsA. Two hundred forty-nine unrelated Caucasian PsA patients, 243 psoriasis patients without arthritis, and 248 healthy controls were genotyped for 55 MICA alleles using PCR-SSP, and for human leucocyte antigen (HLA)-B and HLA-C alleles by PCR-SSO reverse line blot. Allele frequencies were calculated and logistic regressions were performed, adjusting for HLA-B and HLA-C alleles previously shown to be associated with psoriasis and/or PsA. Several MICA alleles were associated with psoriatic disease, PsA, and psoriasis compared with controls, and PsA compared with psoriasis in univariate analyses. Haplotype analysis showed evidence of strong linkage disequilibrium (LD) between PsA and psoriasis risk alleles of HLA-C, HLA-B, and MICA. After adjusting for significant HLA-B and HLA-C alleles in multivariate analyses, MICA*016 remained significantly associated with psoriasis [odds ratio (OR) = 5.5, P = 0.008]. MICA*00801 homozygosity was associated with susceptibility to PsA when compared with patients with psoriasis alone (OR = 2.26, P = 0.009). We conclude that most MICA allele associations with psoriasis and PsA are dependent on LD with HLA-B and HLA-C risk alleles. Independent of HLA, only MICA*016 influences the risk of developing psoriasis without arthritis, and homozygosity for MICA*00801 increases the risk of developing PsA in patients with psoriasis. 相似文献
534.
535.
536.
537.
Hanly JG Urowitz MB Su L Bae SC Gordon C Clarke A Bernatsky S Vasudevan A Isenberg D Rahman A Wallace DJ Fortin PR Gladman D Romero-Diaz J Romero-Dirz J Sanchez-Guerrero J Dooley MA Bruce I Steinsson K Khamashta M Manzi S Ramsey-Goldman R Sturfelt G Nived O van Vollenhoven R Ramos-Casals M Aranow C Mackay M Kalunian K Alarcón GS Fessler BJ Ruiz-Irastorza G Petri M Lim S Kamen D Peschken C Farewell V Thompson K Theriault C Merrill JT 《Annals of the rheumatic diseases》2011,70(10):1726-1732
538.
539.
540.
Reich HN Gladman DD Urowitz MB Bargman JM Hladunewich MA Lou W Fan SC Su J Herzenberg AM Cattran DC Wither J Landolt-Marticorena C Scholey JW Fortin PR 《Kidney international》2011,79(8):914-920
Advances in immunotherapy have improved survival of patients with systemic lupus erythematosus who now face an increasing burden of chronic diseases including that of the kidney. As systemic inflammation is also thought to contribute directly to the progression of chronic kidney disease (CKD), we assessed this risk in patients with lupus, with and without a diagnosis of nephritis, and also identified modifiable risk factors. Accordingly, we enrolled 631 patients (predominantly Caucasian), of whom 504 were diagnosed with lupus within the first year and followed them an average of 11 years. Despite the presence of a chronic inflammatory disease, the rate of decline in renal function of 238 patients without nephritis was similar to that described for non-lupus patient cohorts. Progressive loss of kidney function developed exclusively in patients with lupus nephritis who had persistent proteinuria and dyslipidemia, although only six required dialysis or transplantation. The mortality rate was 16% with half of the deaths attributable to sepsis or cancer. Thus, despite the presence of a systemic inflammatory disease, the risk of progressive CKD in this lupus cohort was relatively low in the absence of nephritis. Hence, as in idiopathic glomerular disease, persistent proteinuria and dyslipidemia (modifiable risks) are the major factors for CKD progression in lupus patients with renal involvement. 相似文献