全文获取类型
收费全文 | 562篇 |
免费 | 61篇 |
专业分类
儿科学 | 6篇 |
妇产科学 | 3篇 |
基础医学 | 30篇 |
临床医学 | 28篇 |
内科学 | 456篇 |
皮肤病学 | 16篇 |
神经病学 | 21篇 |
特种医学 | 2篇 |
外科学 | 31篇 |
综合类 | 5篇 |
预防医学 | 9篇 |
眼科学 | 1篇 |
药学 | 11篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 14篇 |
2018年 | 6篇 |
2017年 | 9篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 13篇 |
2013年 | 17篇 |
2012年 | 37篇 |
2011年 | 57篇 |
2010年 | 14篇 |
2009年 | 13篇 |
2008年 | 43篇 |
2007年 | 45篇 |
2006年 | 35篇 |
2005年 | 42篇 |
2004年 | 21篇 |
2003年 | 24篇 |
2002年 | 15篇 |
2001年 | 15篇 |
2000年 | 30篇 |
1999年 | 19篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 6篇 |
1992年 | 22篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有623条查询结果,搜索用时 15 毫秒
101.
102.
Although there is still some controversy about the existence of psoriatic arthritis (PsA) as a specific form of inflammatory arthritis associated with psoriasis, epidemiological and clinical studies support the unique features of PsA. Because of lack of diagnostic or classification criteria, the disease has been thought of as uncommon. New classification criteria should facilitate case definition of PsA. Over the past several decades, it has become clear that the disease leads to serious disability and even increased mortality. Traditional medications have not been effective in preventing the progression of joint damage. New medications, including biologics, have emerged with potential to controlling the inflammation and arresting the progression of joint damage. 相似文献
103.
Hypocalcemia secondary to nutritional rickets is a rare cause of dilated cardiomyopathy. It is also not a recognized cause of dicarboxylic aciduria. We report the first case of adipic aciduria, presenting with dilated cardiomyopathy, secondary to hypocalcemia. 相似文献
104.
HLA-DRB1*04 alleles in psoriatic arthritis: comparison with rheumatoid arthritis and healthy controls. 总被引:5,自引:0,他引:5
D D Gladman V T Farewell P Rahman C T Schentag F Pellett C M Ng J A Wade 《Human immunology》2001,62(11):1239-1244
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis usually seronegative for rheumatoid factor. An increased frequency of HLA-DR4 has been noted in PsA, particularly among patients with a rheumatoid arthritis like (RA) arthritis. The aim of the current investigation was to compare HLA-DRB1*04 alleles in patients with PsA, patients with RA, and healthy controls. Sample size calculations based on the frequency of HLA-DR4 suggested that 90 individuals in each patient group would be sufficient to address our question. Therefore, 90 HLA-DRB1*04 positive patients from each patient group underwent high resolution molecular typing and were included in this study. Although HLA-DRB1*0401 was the most frequent allele in all groups, its frequency among the PsA patients was lower than that of RA patients and controls. HLA-DRB1*0402 was higher among patients with PsA. Patients with RA were more likely to have more than one shared epitope allele than either PsA or the healthy control group. HLA-DQB1 alleles did not contribute further information. We suggest that the differences in the class II HLA epitope(s) may also be related to interaction specificity with another molecule functioning in the immune response to a putative arthritogenic antigen and result in differences in disease expression. 相似文献
105.
Park Seiwon Silverberg Orli M. Moez Elham Chandran Vinod Gladman Dafna D. 《Clinical rheumatology》2022,41(12):3753-3757
Clinical Rheumatology - The 2014 Update of the Canadian treatment recommendations for the management of spondyloarthritis recommended that patients at risk of peripheral spondyloarthritis,... 相似文献
106.
Psoriatic arthritis 总被引:1,自引:0,他引:1
D D Gladman 《Current opinion in rheumatology》1990,2(4):577-581
Psoriatic arthritis is a common form of arthritis. It is recognized that there is a subset of patients who have a severe, disabling form of the disease, and that patients need to be treated earlier if a good outcome is to occur. The pathogenesis of psoriatic arthritis is still unclear, but the "experiment of nature" provided by the HIV infection may help further outline the causative mechanisms. Newer modalities of therapy are being investigated. 相似文献
107.
108.
109.
110.
S P Vasudevan S M Scott M A Gladman P J Lunniss 《Neurogastroenterology and motility》2007,19(8):660-667
Rectal hyposensitivity (RH) is commonly found in patients with intractable constipation, faecal incontinence or both. Anal sensation may also be blunted in these conditions. We aimed to determine whether RH is associated with anal hyposensitivity, which may reflect a combined viscero-somatic neuropathy. One hundred and fifty-eight female patients with chronic constipation underwent physiological investigation including rectal sensation to volumetric balloon distension, and distal anal mucosal sensation to electrostimulation. Data were also obtained from 32 healthy female volunteers. Anal mucosal electrosensory thresholds were significantly higher in patients compared with volunteers (median: 2.4 mA, range: 0.4-19.6 vs 1.1 mA, range: 0.1-4.2, respectively), although the patient group was older (P < 0.0001), but there was no difference (P = 0.572) in the incidence of blunted anal sensation between those with normal rectal sensation (n = 113, 20% abnormal) and RH (n = 45, 24% abnormal). Irrespective of rectal sensory function, there was a strong association between symptom duration (P = 0.012) and anal hyposensitivity. One-fifth of constipated female patients had evidence of diminished anal sensation. However, the presence of RH was not associated with an increased frequency of anal hyposensitivity, thereby suggesting that different aetiopathogenic mechanisms underlie the development of anal and rectal hyposensitivity. Further studies in carefully selected, homogenous patient populations are necessary to elucidate these mechanisms. 相似文献