全文获取类型
收费全文 | 2776篇 |
免费 | 163篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 97篇 |
妇产科学 | 57篇 |
基础医学 | 399篇 |
口腔科学 | 50篇 |
临床医学 | 218篇 |
内科学 | 804篇 |
皮肤病学 | 38篇 |
神经病学 | 274篇 |
特种医学 | 49篇 |
外科学 | 201篇 |
综合类 | 5篇 |
预防医学 | 140篇 |
眼科学 | 10篇 |
药学 | 288篇 |
中国医学 | 21篇 |
肿瘤学 | 283篇 |
出版年
2023年 | 15篇 |
2022年 | 61篇 |
2021年 | 80篇 |
2020年 | 48篇 |
2019年 | 60篇 |
2018年 | 77篇 |
2017年 | 63篇 |
2016年 | 70篇 |
2015年 | 89篇 |
2014年 | 102篇 |
2013年 | 131篇 |
2012年 | 215篇 |
2011年 | 226篇 |
2010年 | 102篇 |
2009年 | 137篇 |
2008年 | 228篇 |
2007年 | 193篇 |
2006年 | 161篇 |
2005年 | 178篇 |
2004年 | 184篇 |
2003年 | 140篇 |
2002年 | 129篇 |
2001年 | 25篇 |
2000年 | 21篇 |
1999年 | 18篇 |
1998年 | 31篇 |
1997年 | 28篇 |
1996年 | 20篇 |
1995年 | 16篇 |
1994年 | 8篇 |
1993年 | 10篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 10篇 |
1989年 | 8篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1967年 | 3篇 |
1890年 | 2篇 |
排序方式: 共有2962条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
Margherita Vinciguerra Monica Cannata Filippo Cassarà Cristina Passarello Filippo Leto Giuseppina Calvaruso 《Hemoglobin》2017,41(4-6):234-238
We report two very rare changes in the second intron of the HBB gene, a substitution at nucleotide (nt) 726 [IVS-II-726 (A>G) (β+), NM_000518, HBB: c.316-125A>G] and a deletion of a cytosine at nt 809 [IVS-II-809 (–C) (β), NM_000518, HBB: c.316-42delC] identified during the screening program for hemoglobinopathies in the resident Sicilian population. The purpose of this study was to evaluate the clinical implication of these rare changes, particularly in coinheritance with known mutations in the globin clusters, in order to conduct an appropriate genetic counseling for at-risk couples. Molecular analysis detected the first rare nt substitution in two cases in simple heterozygosity and in two cases in association with other known mutations on globin genes, while the deletion was identified in a pregnant woman, carrier of β-thal, and in her fetus at prenatal diagnosis (PND) for hemoglobinopathies. The present study emphasizes the importance of sharing the observed changes in the globin gene cluster, especially in the case of new or rare undefined mutations, in order to facilitate the determination of their phenotypic expression and possible interactions with known molecular defects. 相似文献
35.
Chaima Ragoubi Laura Quintieri Donato Greco Amel Mehrez Imed Maatouk Vito DAscanio Ahmed Landoulsi Giuseppina Avantaggiato 《Toxins》2021,13(3)
The removal of mycotoxins from contaminated feed using lactic acid bacteria (LAB) has been proposed as an inexpensive, safe, and promising mycotoxin decontamination strategy. In this study, viable and heat-inactivated L. acidophilus CIP 76.13T and L. delbrueckii subsp. bulgaricus CIP 101027T cells were investigated for their ability to remove aflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEA), and deoxynivalenol (DON) from MRS medium and PBS buffer over a 24 h period at 37 °C. LAB decontamination activity was also assessed in a ZEA-contaminated liquid feed (LF). Residual mycotoxin concentrations were determined by UHPLC-FLD/DAD analysis. In PBS, viable L. acidophilus CIP 76.13T and L. delbrueckii subsp. bulgaricus CIP 101027T cells removed up to 57% and 30% of ZEA and DON, respectively, while AFB1 and OTA reductions were lower than 15%. In MRS, 28% and 33% of ZEA and AFB1 were removed, respectively; OTA and DON reductions were small (≤15%). Regardless of the medium, heat-inactivated cells produced significantly lower mycotoxin reductions than those obtained with viable cells. An adsorption mechanism was suggested to explain the reductions in AFB1 and OTA, while biodegradation could be responsible for the removal of ZEA and DON. Both viable LAB strains reduced ZEA by 23% in contaminated LF after 48 h of incubation. These findings suggest that LAB strains of L. acidophilus CIP 76.13T and L. delbrueckii subsp. bulgaricus CIP 101027T may be applied in the feed industry to reduce mycotoxin contamination. 相似文献
36.
Lo Casto Antonio Cannella Roberto Taravella Rossana Cordova Adriana Matta Daniele Campisi Giuseppina Attanasio Massimo Rinaldi Gaetana Rodolico Vito 《La Radiologia medica》2022,127(12):1364-1372
La radiologia medica - To evaluate the accuracy of preoperative contrast-enhanced magnetic resonance imaging (MRI) in the assessment of radiological depth of invasion (rDOI) and bone invasion in... 相似文献
37.
38.
39.
Cancer cells undergo genetic changes allowing their adaptation to environmental changes, thereby obtaining an advantage during the long metastatic route, disseminated of several changes in the surrounding environment. In particular, plasticity in cell motility, mainly due to epigenetic regulation of cancer cells by environmental insults, engage adaptive strategies aimed essentially to survive in hostile milieu, thereby escaping adverse sites. This review is focused on tumor microenvironment as a collection of structural and cellular elements promoting plasticity and adaptive programs. We analyze the role of extracellular matrix stiffness, hypoxia, nutrient deprivation, acidity, as well as different cell populations of tumor microenvironment. 相似文献
40.