全文获取类型
收费全文 | 28516篇 |
免费 | 1415篇 |
国内免费 | 273篇 |
专业分类
耳鼻咽喉 | 249篇 |
儿科学 | 581篇 |
妇产科学 | 760篇 |
基础医学 | 3117篇 |
口腔科学 | 566篇 |
临床医学 | 2480篇 |
内科学 | 8182篇 |
皮肤病学 | 573篇 |
神经病学 | 2476篇 |
特种医学 | 994篇 |
外科学 | 4582篇 |
综合类 | 69篇 |
一般理论 | 6篇 |
预防医学 | 1044篇 |
眼科学 | 390篇 |
药学 | 1540篇 |
中国医学 | 47篇 |
肿瘤学 | 2548篇 |
出版年
2024年 | 27篇 |
2023年 | 242篇 |
2022年 | 483篇 |
2021年 | 816篇 |
2020年 | 520篇 |
2019年 | 685篇 |
2018年 | 797篇 |
2017年 | 630篇 |
2016年 | 757篇 |
2015年 | 823篇 |
2014年 | 1041篇 |
2013年 | 1440篇 |
2012年 | 2219篇 |
2011年 | 2192篇 |
2010年 | 1285篇 |
2009年 | 1152篇 |
2008年 | 2029篇 |
2007年 | 1916篇 |
2006年 | 1761篇 |
2005年 | 1759篇 |
2004年 | 1622篇 |
2003年 | 1431篇 |
2002年 | 1335篇 |
2001年 | 242篇 |
2000年 | 203篇 |
1999年 | 230篇 |
1998年 | 247篇 |
1997年 | 228篇 |
1996年 | 176篇 |
1995年 | 191篇 |
1994年 | 162篇 |
1993年 | 148篇 |
1992年 | 135篇 |
1991年 | 118篇 |
1990年 | 144篇 |
1989年 | 100篇 |
1988年 | 72篇 |
1987年 | 73篇 |
1986年 | 77篇 |
1985年 | 80篇 |
1984年 | 72篇 |
1983年 | 58篇 |
1982年 | 61篇 |
1981年 | 35篇 |
1980年 | 48篇 |
1979年 | 43篇 |
1977年 | 23篇 |
1975年 | 21篇 |
1974年 | 28篇 |
1973年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
Enrico Gervasi Araldo Causero Pier Camillo Parodi Diego Raimondo Giuseppe Tancredi 《Arthroscopy》2007
The patient is placed in lateral decubitus. A 6-cm incision made in the axilla allows access to the latissimus dorsi tendon and its neurovascular pedicle. Holding the arm in internal rotation, the surgeon detaches sharply the tendon off the humeral shaft and then reinforces it with wrapping sutures. Pulling the free limbs of the sutures exposes the under surface of the muscle and helps to identify the neurovascular pedicle. Special lighting retractors suited for a large diameter scope are helpful. Mobilization is completed when 2 cm of the tendon crosses the posterior edge of the acromion. The standard lateral portal is used for visualization. A silicon drain tube stiffened by a Wissinger rod is advanced from the posterior portal under direct visualization in the space between teres minor and deltoid, exiting in the auxiliary incision. A suture loop passed down the tube retrieves the tendon sutures out the posterior portal. These are then moved out the anterior portal, thus pulling the tendon over the tuberosity. The first anchor is inserted at the anterior aspect of the greater tuberosity, close to the articular cartilage and long head of the biceps tendon. Two to 3 anchors are inserted fixing the tendon to the tuberosity until it is stable. 相似文献
42.
43.
Sir, The comment of Attilio Di Spiezio Sardo et al. was very interesting.They reported the results of their studies on the effects ofintranasal and transdermal 相似文献
44.
Giuseppe Derosa Arrigo F G Cicero Angela D'Angelo Pietro D Ragonesi Leonardina Ciccarelli Mario N Piccinni Fabio Pricolo Sibilla A T Salvadeo Ilaria Ferrari Alessia Gravina Roberto Fogari 《Hypertension research》2006,29(11):849-856
The aim of our study was to investigate the metabolic effect of telmisartan and irbesartan in subjects treated with rosiglitazone, a well-known insulin-sensitizing drug, in order to clarify the direct metabolic effects of the two former drugs. Patients were enrolled, evaluated, and followed at 3 Italian centers. We evaluated 188 type 2 diabetic patients with metabolic syndrome (94 males and 94 females in total; 49 males and 46 females, aged 56+/-5, treated with telmisartan; and 45 males and 48 females, aged 55+/-4, treated with irbesartan). All had been diabetic for at least 6 months, and glycemic control by the maximum tolerated dietary changes and maximum tolerated dose of oral hypoglycemic agents had been attempted and failed in all cases. All patients took a fixed dose of rosiglitazone, 4 mg/day. We administered telmisartan (40 mg/day) or irbesartan (150 mg/day) in a randomized, controlled, double-blind clinical manner. We evaluated body mass index (BMI), glycemic control (HbA1c fasting plasma glucose and insulin levels [FPG, and FPI, respectively], and homeostasis model assessment [HOMA] index), lipid profile (total cholesterol [TC], low density lipoprotein-cholesterol [LDL-C], high density lipoprotein-cholesterol [HDL-C], and triglycerides [TG]), systolic and diastolic blood pressure (SBP and DBP), tumor necrosis factor-alpha (TNF-alpha), and leptin during the 12 months of this treatment. No BMI change was observed after 6 or 12 months in either group. Significant decreases in HbAlc and FPG were observed after 6 months in the telmisartan group, and after 12 months in both groups. The decrease in HbA1c and FPG at 12 months was statistically significant only in the telmisartan group. A significant decrease in FPI was observed at 12 months in both groups, and this decrease was significantly greater in the telmisartan group. Significant decreases in the HOMA index were observed at 6 and 12 months in both groups, and the decrease in the HOMA index after 12 months was significantly greater in the telmisartan group than in the irbesartan group. Significant changes in SBP, DBP, TC, and LDL-C were observed after 6 and 12 months in both groups. Significant decreases in TNF-alpha and leptin levels were observed after 6 months in the telmisartan group, and after 12 months in both groups. In conclusion, in this study of patients with type 2 diabetes mellitus and metabolic syndrome, telmisartan seemed to result in a greater improvement in glycemic and lipid control and metabolic parameters related to metabolic syndrome compared to irbesartan. These observed metabolic effects of different angiotensin type 1 receptor blockers could be relevant when choosing a therapy to correct metabolic derangement of patients affected by metabolic syndrome and diabetes. 相似文献
45.
Cristina Tassorelli Francesca Mancini Laura Balloni Claudio Pacchetti Giorgio Sandrini Giuseppe Nappi Emilia Martignoni 《Movement disorders》2006,21(12):2240-2243
Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single-center, cross-over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX-A) plus a specific program of physical therapy (BTX-PT) or (2) BTX-A alone (BTX-0). Patients in the BTX-PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (-9.7 vs. -4.85 points) and subjective pain (-13.35 vs. 6.95 points) scores. Association of BTX-A therapy with a specific program of physical therapy may improve ICD treatment outcome. 相似文献
46.
Alan A Arslan Anne Zeleniuch-Jacquotte Annekatrin Lukanova Yelena Afanasyeva Joseph Katz Mortimer Levitz Giuseppe Del Priore Paolo Toniolo 《Cancer epidemiology, biomarkers & prevention》2006,15(11):2123-2130
Epidemiologic evidence suggests that a full-term pregnancy may affect maternal risk of breast cancer later in life. The objective of this cross-sectional study was to compare circulating levels of maternal hormones affecting breast differentiation (human chorionic gonadotropin and prolactin) and proliferation [alpha-fetoprotein, insulin-like growth factor I (IGF-I), and estradiol] between women at a low to moderate risk (Asians and Hispanics), as compared with women at a high risk for breast cancer (Caucasians and African-Americans). Between May 2002 and December 2004, a total of 586 pregnant women were approached during a routine prenatal visit. Among them, 450 women (206 Caucasian, 126 Asian, 88 Hispanic, and 30 African-American) met the inclusion criteria and signed the informed consent. Only singleton pregnancies were considered. Blood samples were drawn during the second trimester of pregnancy. Laboratory analyses were done using the IMMULITE 2000 immunoassay system. Gestational age standardized mean levels of estradiol, IGF-I, and prolactin were significantly higher in Hispanic women compared with Caucasian women. Mean concentration of IGF-I was significantly higher in African-American women compared with Caucasian and Asian women. No significant differences in pregnancy hormone levels were observed between Caucasian and Asian (predominantly second-generation Chinese) women in this study. Irrespective of ethnicity, women who had their first pregnancy had substantially higher mean levels of alpha-fetoprotein, human chorionic gonadotropin, estradiol, and prolactin compared with women who previously had at least one full-term pregnancy. These data suggest that circulating pregnancy hormone levels may explain some of the ethnic differences in breast cancer risk. 相似文献
47.
A Ferlito G Caruso 《ORL; journal for oto-rhino-laryngology and its related specialties》1991,53(2):116-119
An extremely rare case of synovial sarcoma localized in the larynx is reported together with a review of 6 similar neoplasms previously reported in this unusual region. In this case, the patient is still tumor free 16 years after therapy. 相似文献
48.
C Caruso G Di Lorenzo M A Modica G Candore M R Portelli G Crescimanno A Ingrassia G B Sangiorgi A Salerno 《Mechanisms of ageing and development》1991,59(1-2):27-35
The evidence from several studies indicates that as individuals age, they may display immune dysfunctions, mostly T cell dysfunctions. Recently, a soluble form of the receptor for interleukin-2 (IL-2) (sIL-2R) has been demonstrated in human sera and in vitro stimulated culture supernatants from human T lymphocytes. In the present paper, we report in vitro sIL-2R production from peripheral blood mononuclear cells in elderly subjects. The results show that no difference exists for unstimulated cultures, whereas after mitogen stimulation the elderly subjects showed the lowest values compared with young ones. These findings suggest that sIL-2R may provide a new tool for the study of T lymphocyte dysfunctions in old age. 相似文献
49.
S Plescia G Daidone D Raffa M L Bajardi A Caruso V Cutuli M Amico-Roxas 《Il Farmaco; edizione pratica》1992,47(4):465-475
A number of new 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones was prepared and tested, together a few analogues previously obtained, for their analgesic, antipyretic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects. In the carrageenan rat foot edema model one of the tested compounds showed activity and LD50 comparable to that of ASA, but the ulceration index approximated zero value. 相似文献
50.
Driven by research findings regarding the positive relationship between training and enhancement of services, as well as literature on adult learning, the New England Head Start Teaching Center (NEHSTC) was created in 1992 to test the efficacy of participatory, hands-on training. The purpose of this paper is to examine the outcome evaluation results from 4 years of training at the NEHSTC, 1 of 14 federally funded sites, as well as to discuss the implications for delivering this type of participatory training throughout Head Start. Findings suggest that the NEHSTC was successful in implementing high quality, participatory training within the context of an ongoing Head Start program. Head Start staff who participated in the NEHSTC trainings demonstrated gains in knowledge, skills, and expertise compared to similar Head Start employees who did not receive training. Results also reveal a sustained effect of training over time, with NEHSTC participants continuing to demonstrate enhanced knowledge and skills 6 months after training. Similar positive outcomes of training were found for staff with varying levels of experience and holding different Head Start positions. Thus the participatory, hands-on training implemented by the NEHSTC was found to produce positive and lasting outcomes for diverse Head Start staff. An effective and cost efficient model of training Head Start personnel is particularly relevant and timely as Head Start strives to establish universal quality and expansion of services in the 21st Century. The findings are also relevant for improving the quality of all early care and education programs. 相似文献