全文获取类型
收费全文 | 3094篇 |
免费 | 196篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 45篇 |
妇产科学 | 56篇 |
基础医学 | 394篇 |
口腔科学 | 27篇 |
临床医学 | 351篇 |
内科学 | 999篇 |
皮肤病学 | 59篇 |
神经病学 | 299篇 |
特种医学 | 35篇 |
外科学 | 228篇 |
综合类 | 15篇 |
一般理论 | 1篇 |
预防医学 | 286篇 |
眼科学 | 46篇 |
药学 | 231篇 |
中国医学 | 10篇 |
肿瘤学 | 192篇 |
出版年
2024年 | 6篇 |
2023年 | 33篇 |
2022年 | 112篇 |
2021年 | 121篇 |
2020年 | 83篇 |
2019年 | 100篇 |
2018年 | 91篇 |
2017年 | 86篇 |
2016年 | 80篇 |
2015年 | 83篇 |
2014年 | 147篇 |
2013年 | 151篇 |
2012年 | 220篇 |
2011年 | 253篇 |
2010年 | 108篇 |
2009年 | 125篇 |
2008年 | 152篇 |
2007年 | 172篇 |
2006年 | 156篇 |
2005年 | 159篇 |
2004年 | 159篇 |
2003年 | 155篇 |
2002年 | 137篇 |
2001年 | 41篇 |
2000年 | 36篇 |
1999年 | 23篇 |
1998年 | 28篇 |
1997年 | 21篇 |
1996年 | 10篇 |
1995年 | 18篇 |
1994年 | 7篇 |
1993年 | 10篇 |
1992年 | 10篇 |
1991年 | 21篇 |
1990年 | 19篇 |
1989年 | 12篇 |
1988年 | 17篇 |
1987年 | 23篇 |
1986年 | 16篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 12篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 19篇 |
1977年 | 4篇 |
1974年 | 6篇 |
1971年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有3307条查询结果,搜索用时 15 毫秒
21.
Rebecca Ortiz La Banca Flvio Rebustini Willyane A. Alvarenga Emilia C. de Carvalho Mayara Lopes Kerry Milaszewski Lucila C. Nascimento 《Journal of diabetes science and technology》2022,16(3):742
Background:School-aged children often participate in type 1 diabetes (T1D) self-care tasks. Despite widespread discussion about the importance of developing self-care skills in childhood, few explain how the health care team should assess the skills of children with T1D when performing insulin injections.Objective:We sought to assess content validity evidence in two checklists regarding injection technique performed by children.Methods:Two checklists were designed based on a systematic review of the insulin injection technique. Experts in pediatric diabetes, health literacy, and diabetes education assessed the checklists regarding their clarity, objectivity, and relevance. Content validity was assessed using the content validity ratio (CVR).Results:Eleven providers (72% nurses or physicians, professional experience 19.4 ± 10.1 years, 45% of specialists in endocrinology, and 18% in pediatrics) participated in the assessment. Experts considered items containing the word homogeneity inappropriate. Items related to the needle insertion angle and the skin fold did not reach the CVR critical value. The final version of the checklist for syringe injection comprised 22 items with CVR = 0.91, and the checklist for pen injection comprised 18 items with CVR = 0.87.Conclusions:The checklists presented clear, objective, and relevant content that assesses the skills of children with T1D for insulin injection. The checklists formally present the order of the technique and all the steps for insulin injection and allow a quantitative assessment of the operational skills of children. The developed instruments offer providers the possibility of continuous assessment of the progress of the pediatric clientele until they reach independence in diabetes self-care. 相似文献
22.
Coaxial Drainage versus Standard Chest Tube after Pulmonary Lobectomy: A Randomized Controlled Study
Massimiliano Bassi Emilia Mottola Sara Mantovani Davide Amore Andreina Pagini Daniele Diso Jacopo Vannucci Camilla Poggi Tiziano De Giacomo Erino Angelo Rendina Federico Venuta Marco Anile 《Current oncology (Toronto, Ont.)》2022,29(7):4455
Chest tubes are routinely inserted after thoracic surgery procedures in different sizes and numbers. The aim of this study is to assess the efficacy of Smart Drain Coaxial drainage compared with two standard chest tubes in patients undergoing thoracotomy for pulmonary lobectomy. Ninety-eight patients (57 males and 41 females, mean age 68.3 ± 7.4 years) with lung cancer undergoing open pulmonary lobectomy were randomized in two groups: 50 received one upper 28-Fr and one lower 32-Fr standard chest tube (ST group) and 48 received one 28-Fr Smart Drain Coaxial tube (SDC group). Hospitalization, quantity of fluid output, air leaks, radiograph findings, pain control and costs were assessed. SDC group showed shorter hospitalization (7.3 vs. 6.1 days, p = 0.02), lower pain in postoperative day-1 (p = 0.02) and a lower use of analgesic drugs (p = 0.04). Pleural effusion drainage was lower in SDC group in the first postoperative day (median 400.0 ± 200.0 mL vs. 450.0 ± 193.8 mL, p = 0.04) and as a mean of first three PODs (median 325.0 ± 137.5 mL vs. 362.5 ± 96.7 mL, p = 0.01). No difference in terms of fluid retention, residual pleural space, subcutaneous emphysema and complications after chest tubes removal was found. In conclusion, Smart Drain Coaxial chest tube seems a feasible option after thoracotomy for pulmonary lobectomy. The SDC group showed a shorter hospitalization and decreased analgesic drugs use and, thus, a reduction of costs. 相似文献
23.
Emilia Sokolowska Bartlomiej Kalaska Joanna Miklosz 《Expert opinion on drug metabolism & toxicology》2016,12(8):897-909
Introduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in medicine to prevent blood clotting. In the case of an emergency bleeding in response to heparin, the protamine sulfate is administered. Despite its extensive clinical use, protamine may produce life-threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. Recent studies have demonstrated new organ-specific complications of the heparin reversal with protamine.Areas covered: Past and present knowledge of the mechanisms responsible for the toxicity of protamine and the most promising potential replacements of protamine in the different phases of development.Expert opinion: Despite of the low therapeutic index, protamine is the only registered antidote of heparins. The toxicology of protamine depends on a complex interaction of the high molecular weight, a cationic peptide with the surfaces of the vasculature and blood cells. The mechanisms involve membrane receptors and ion channels targeted by different vasoactive compounds, such as nitric oxide, bradykinin or histamine. Unacceptable side effects of protamine have led to a search for new alternatives: UHRA, LMWP, and Dex40-GTMAC3 are in the preclinical stage; the two other agents (andexanet alfa and PER977) are already in the advanced clinical phases. 相似文献
24.
25.
26.
Emilia A. Korhonen Aino Murtomki Sawan Kumar Jha Andrey Anisimov Anne Pink Yan Zhang Simon Stritt Inam Liaqat Lukas Stanczuk Laura Alderfer Zhiliang Sun Emmi Kapiainen Abhishek Singh Ibrahim Sultan Anni Lantta Veli-Matti Leppnen Lauri Eklund Yulong He Hellmut G. Augustin Kari Vaahtomeri Pipsa Saharinen Taija Mkinen Kari Alitalo 《The Journal of clinical investigation》2022,132(15)
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel development, and mutations of the ANGPT2 gene were recently found in human primary lymphedema. However, the mechanistic basis of Ang2 activity in lymphangiogenesis is not fully understood. Here, we used gene deletion, blocking Abs, transgene induction, and gene transfer to study how Ang2, its Tie2 receptor, and Tie1 regulate lymphatic vessels. We discovered that VEGF-C–induced Ang2 secretion from lymphatic endothelial cells (LECs) was involved in full Akt activation downstream of phosphoinositide 3 kinase (PI3K). Neonatal deletion of genes encoding the Tie receptors or Ang2 in LECs, or administration of an Ang2-blocking Ab decreased VEGFR3 presentation on LECs and inhibited lymphangiogenesis. A similar effect was observed in LECs upon deletion of the PI3K catalytic p110α subunit or with small-molecule inhibition of a constitutively active PI3K located downstream of Ang2. Deletion of Tie receptors or blockade of Ang2 decreased VEGF-C–induced lymphangiogenesis also in adult mice. Our results reveal an important crosstalk between the VEGF-C and Ang signaling pathways and suggest new avenues for therapeutic manipulation of lymphangiogenesis by targeting Ang2/Tie/PI3K signaling. 相似文献
27.
28.
Emilia Mikołajewska 《Central European Journal of Medicine》2012,7(3):354-357
Pusher syndrome is classically described as disorder of body orientation in the coronal plane. It is characterized by a tilt towards the contralesional paretic side and a resistance to external attempts to rectify. It occurs mainly in stroke patients, however, non-stroke causes have been described too. In 2010 the concept of the posterior pusher syndrome had been proposed, defined as disturbance of body orientation in the sagittal plane with imbalance, posterior tilt and an active resistance to forward pulling or pushing. The author describes, on the basis of the literature and own research, symptoms and methods of the treatment of the little-known posterior pusher syndrome. 相似文献
29.
30.
Kathryn H. Bowles Sarah J. Ratcliffe John H. Holmes Sue Keim Sheryl Potashnik Emilia Flores Diane Humbrecht Christina R. Whitehouse Mary D. Naylor 《Journal of the American Medical Directors Association》2019,20(4):408-413