全文获取类型
收费全文 | 5683篇 |
免费 | 379篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 185篇 |
妇产科学 | 118篇 |
基础医学 | 824篇 |
口腔科学 | 247篇 |
临床医学 | 448篇 |
内科学 | 1560篇 |
皮肤病学 | 132篇 |
神经病学 | 570篇 |
特种医学 | 134篇 |
外科学 | 465篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 297篇 |
眼科学 | 29篇 |
药学 | 366篇 |
中国医学 | 5篇 |
肿瘤学 | 695篇 |
出版年
2024年 | 8篇 |
2023年 | 51篇 |
2022年 | 131篇 |
2021年 | 182篇 |
2020年 | 114篇 |
2019年 | 136篇 |
2018年 | 164篇 |
2017年 | 110篇 |
2016年 | 143篇 |
2015年 | 169篇 |
2014年 | 247篇 |
2013年 | 301篇 |
2012年 | 470篇 |
2011年 | 438篇 |
2010年 | 256篇 |
2009年 | 228篇 |
2008年 | 410篇 |
2007年 | 397篇 |
2006年 | 386篇 |
2005年 | 373篇 |
2004年 | 312篇 |
2003年 | 301篇 |
2002年 | 310篇 |
2001年 | 34篇 |
2000年 | 20篇 |
1999年 | 25篇 |
1998年 | 54篇 |
1997年 | 49篇 |
1996年 | 33篇 |
1995年 | 38篇 |
1994年 | 28篇 |
1993年 | 13篇 |
1992年 | 20篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 11篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 16篇 |
1985年 | 10篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 11篇 |
1981年 | 13篇 |
1980年 | 5篇 |
1978年 | 4篇 |
1976年 | 3篇 |
1974年 | 5篇 |
1972年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有6116条查询结果,搜索用时 15 毫秒
61.
Biological width formation to immediate implants placed at different level in relation to the crestal bone: an experimental study in dogs 下载免费PDF全文
62.
63.
Alberto Vaiarelli Danilo Cimadomo Antonio Capalbo Giovanna Orlando Fabio Sapienza Silvia Colamaria Antonio Palagiano Carlo Bulletti Laura Rienzi Filippo Maria Ubaldi 《Journal of assisted reproduction and genetics》2016,33(10):1273-1278
Pre-implantation genetic diagnosis for aneuploidy testing (PGD-A) is a tool to identify euploid embryos during IVF. The suggested populations of patients that can benefit from it are infertile women of advanced maternal age, with a history of recurrent miscarriages and/or IVF failures. However, a general consensus has not yet been reached.After the clinical failure of its first version based on cleavage stage biopsy and 9 chromosome-FISH analysis, PGD-A is currently performed by 24 chromosome screening techniques on trophectoderm (TE) biopsies. This approach has been clearly demonstrated to involve a higher clinical efficiency with respect to the standard care, in terms of sustained pregnancy rate per transfer and lower miscarriage rate. However, data about PGD-A efficacy calculated on a per intention-to-treat basis, as well as an analysis of its cost-effectiveness, are still missing.TE biopsy is a safe and extensively validated approach with low biological and technical margin of error. Firstly, the prevalence of mosaic diploid/aneuploid blastocysts is estimated to be between 0 and 16 %, thus largely tolerable. Secondly, all the comprehensive chromosome screening (CCS) technologies adapted to, or designed to conduct PGD-A are highly concordant, and qPCR in particular has been proven to show the lowest false positive error rate (0.5 %) and a clinically recognizable error rate per blastocyst of just 0.21 %.In conclusion, there is a sufficient body of evidence to support the clinical application of CCS-based PGD-A on TE biopsies. The main limiting factor is the need for a high-standard laboratory to conduct blastocyst culture, biopsy and vitrification without impacting embryo viability. 相似文献
64.
65.
Roberto Berretta Tito Silvio Patrelli Raffaele Faioli Daniele Mautone Salvatore Gizzo Antonio Mezzogiorno Giovanna Giordano Alberto Bacchi Modena 《International journal of clinical and experimental pathology》2013,6(8):1652-1657
Dedifferentiated endometrial cancer (DEC) is microscopically characterized by the presence of high-grade areas emerging from low-grade tumour. DEC is an aggressive tumour even when the dedifferentiated component represents only 20% of the entire neoplasm. A proper histological diagnosis is essential to define the most appropriate therapeutic approach for these tumors, since they are characterized by a particularly aggressive trend and by an extremely poor prognosis. We report a single case of DEC associated with dedifferentiated and adrenal metastasis, for which the patient underwent both abdominal-pelvic and cerebellar surgery. Dedifferentiated carcinoma of the endometrium is a poorly recognized neoplasm since they have not been clearly defined the histological features discriminating this neoplasm from high-grade endometrioid adenocarcinoma. Revising existing literature we found 79 described cases of central nervous system secondary involvement and 13 cases where the onset of the disease was characterized by neurological signs and symptoms. We could only find two reported cases of adrenal metastases originating from endometrial neoplasia but in no case of dedifferentiated endometrial carcinoma previously described has been reported the concomitant adrenal-cerebellar involvement. 相似文献
66.
Vito D Corleto Cristiano Pagnini Maria Sofia Cattaruzza Ermira Zykaj Emilio Di Giulio Giovanna Margagnoni Emanuela Pilozzi Giancarlo D��Ambra Antonietta Lamazza Enrico Fiori Mario Ferri Luigi Masoni Vincenzo Ziparo Bruno Annibale Gianfranco Delle Fave 《World journal of gastroenterology : WJG》2012,18(45):6614-6619
AIM: To compare the site, age and gender of cases of colorectal cancer (CRC) and polyps in a single referral center in Rome, Italy, during two periods.METHODS: CRC data were collected from surgery/pathology registers, and polyp data from colonoscopy reports. Patients who met the criteria for familial adenomatous polyposis, hereditary non-polyposis colorectal cancer syndrome or inflammatory bowel disease were excluded from the study. Overlap of patients between the two groups (cancers and polyps) was carefully avoided. The χ2 statistical test and a regression analysis were performed.RESULTS: Data from a total of 768 patients (352 and 416 patients, respectively, in periods A and B) who underwent surgery for cancer were collected. During the same time periods, a total of 1693 polyps were analyzed from 978 patients with complete colonoscopies (428 polyps from 273 patients during period A and 1265 polyps from 705 patients during period B). A proximal shift in cancer occurred during the latter years for both sexes, but particularly in males. Proximal cancer increased > 3-fold in period B compared to period A in males [odds ratio (OR) 3.31, 95%CI: 2.00-5.47; P < 0.0001). A similar proximal shift was observed for polyps, particularly in males (OR 1.87, 95%CI: 1.23-2.87; P < 0.0038), but also in females (OR 1.62, 95%CI: 0.96-2.73; P < 0.07).CONCLUSION: The prevalence of proximal proliferative colonic lesions seems to have increased over the last decade, particularly in males. 相似文献
67.
Magdalena Kistowska Gabriele Fenini Dragana Jankovic Laurence Feldmeyer Katrin Kerl Philipp Bosshard Lars E. French 《Experimental dermatology》2014,23(12):884-889
Although being a normal part of the skin flora, yeasts of the genus Malassezia are associated with several common dermatologic conditions including pityriasis versicolour, seborrhoeic dermatitis (SD), folliculitis, atopic eczema/dermatitis (AE/AD) and dandruff. While Malassezia spp. are aetiological agents of pityriasis versicolour, a causal role of Malassezia spp. in AE/AD and SD remains to be established. Previous reports have shown that fungi such as Candida albicans and Aspergillus fumigatus are able to efficiently activate the NLRP3 inflammasome leading to robust secretion of the pro‐inflammatory cytokine IL‐1β. To date, innate immune responses to Malassezia spp. are not well characterized. Here, we show that different Malassezia species could induce NLRP3 inflammasome activation and subsequent IL‐1β secretion in human antigen‐presenting cells. In contrast, keratinocytes were not able to secrete IL‐1β when exposed to Malassezia spp. Moreover, we demonstrate that IL‐1β secretion in antigen‐presenting cells was dependent on Syk‐kinase signalling. Our results identify Malassezia spp. as potential strong inducers of pro‐inflammatory responses when taken up by antigen‐presenting cells and identify C‐type lectin receptors and the NLRP3 inflammasome as crucial actors in this process. 相似文献
68.
Local anesthesia in pediatric dermatologic surgery: Evaluation of a patient‐centered approach 下载免费PDF全文
May El Hachem MD Claudia Carnevale MD Andrea Diociaiuti MD PhD Cristiana De Ranieri PsyD Simona Giancristoforo MD Giovanna Zambruno MD Marta L. Ciofi Degli Atti MD 《Pediatric dermatology》2018,35(1):112-116
Background/Objectives
A few studies have documented the effect of local anesthesia for minor dermatologic surgical procedures on children and their parents. Our objective was to evaluate the psychological effect and global satisfaction of a patient‐centered approach to dermatologic surgery under local anesthesia.Methods
Two self‐administered questionnaires were used to evaluate the distress and global satisfaction of 388 children who underwent dermatologic surgery under local anesthesia, accompanied by oral and written therapeutic education measures (structured information and a cartoon brochure illustrating the procedure) addressed to children and parents. Distraction techniques were also used during the procedures.Results
Although 54.5% of patients manifested some degree of fear, all other parameters analyzed (pain, surgery‐related distress, surgical team–patient and –family relationship, global satisfaction) indicated that the procedures resulted in limited distress and that the large majority of children and parents tolerated them well.Conclusion
Specific measures for therapeutic pediatric patient education may be helpful in limiting discomfort, anxiety, and pain perception linked to procedures performed under local anesthesia. Further controlled studies are required to more precisely assess the benefits of specific therapeutic education measures. 相似文献69.
Laura Teodori Anna Giovanetti Maria Cristina Albertini Marco Rocchi Barbara Perniconi Maria Giovanna Valente Dario Coletti 《Journal of radiation research》2014,55(2):218-227
Although static magnetic fields (SMFs) are used extensively in the occupational and medical fields, few comprehensive studies have investigated their possible genotoxic effect and the findings are controversial. With the advent of magnetic resonance imaging-guided radiation therapy, the potential effects of SMFs on ionizing radiation (IR) have become increasingly important. In this study we focused on the genotoxic effect of 80 mT SMFs, both alone and in combination with (i.e. preceding or following) X-ray (XR) irradiation, on primary glioblastoma cells in culture. The cells were exposed to: (i) SMFs alone; (ii) XRs alone; (iii) XR, with SMFs applied during recovery; (iv) SMFs both before and after XR irradiation. XR-induced DNA damage was analyzed by Single Cell Gel Electrophoresis assay (comet assay) using statistical tools designed to assess the tail DNA (TD) and tail length (TL) as indicators of DNA fragmentation. Mitochondrial membrane potential, known to be affected by IR, was assessed using the JC-1 mitochondrial probe. Our results showed that exposure of cells to 5 Gy of XR irradiation alone led to extensive DNA damage, which was significantly reduced by post-irradiation exposure to SMFs. The XR-induced loss of mitochondrial membrane potential was to a large extent averted by exposure to SMFs. These data suggest that SMFs modulate DNA damage and/or damage repair, possibly through a mechanism that affects mitochondria. 相似文献