Predicting financial deficits from a standard neuropsychological assessment: preliminary evidence in mild cognitive impairment

Neurological Sciences - Patients with mild cognitive impairment (MCI) might experience difficulties in numerical and financial abilities of daily living that compromise their autonomy. The aim of...     

Arthroscopic posterior bone block: surgical technique

Posterior glenohumeral instability remains a difficult problem. There are still many controversies regarding surgical treatment, due to a lack of understanding the pathomechanical issues leading to posterior instability. This article presents a new arthroscopic technique of posterior bone block augmentation, which we found to be effective, repeatable and successful. This technique can be used for combined soft tissue and bony defects as well as for revisions after previous soft tissue reconstructions.     

Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses

We previously reported the characterization of human osteoclast-associated receptor (hOSCAR), a novel Fc receptor gamma-chain (FcRgamma)-associated receptor expressed by myeloid cells. Here we show that ligation of hOSCAR by specific antibodies promotes dendritic cell (DC) survival by an extracellular signal-regulated kinase (ERK)- and phosphatidylinositol 3-kinase (PI3K)-dependent pathway, linked to expression of the Bcl-2 and Bcl-x(L) antiapoptotic molecules. Crosslinking of hOSCAR leads to maturation of DCs, as demonstrated by up-regulation of maturation markers, decrease in dextran uptake capacity, and secretion of immunesystem effectors such as interleukin-8 (IL-8)/CXC chemokine ligand 8 (CXCL8), IL-12 p40, monocyte chemoattractant protein-1 (MCP-1)/chemokine receptor ligand 2 (CCL2) and macrophage-derived chemokine (MDC)/CCL22. Stimulation of hOSCAR acts in conjunction with the Toll-like receptor (TLR) ligands, lipopolysaccharide (LPS), R-848, and polyinosinic-polycytidylic acid (poly(I:C)), to increase the expression of maturation markers, and to modulate cytokine release. A PI3K-dependent up-regulation of IL-10 release is observed with all the TLR ligands used, whereas regulation of IL-12 production is variable depending on the TLR stimulated. hOSCAR engagement on DCs did not significantly increase the proliferation of naive T cells; however, when co-incubated with TLR ligands, an enhanced proliferation was observed. The percentage of interferon (IFN)-gamma-producing T cells is decreased when hOSCAR engagement is combined with LPS stimulation. Altogether, these data suggest that hOSCAR may modulate the responses of both innate resistance and adaptive immunity.     

Suppression of the alveolitis in pulmonary sarcoidosis by oral corticosteroids

We evaluated the effects of daily prednisone therapy on alveolitis parameters and pulmonary function tests over a six month period in patients with active pulmonary sarcoidosis (>28% T lymphocytes in bronchoalveolar lavage and positive gallium-67 (⁶⁷Ga) lung scans). 10 patients with biopsyproven lung disease were studied. Analysis of bronchoalveolar lavage cells and of⁶⁷Ga scanning at the beginning and at the end of the study period demonstrated that prednisone treatment significantly lowered the percentages of T lymphocytes in bronchoalveolar lavage in all patients (baseline 48±3%, after treatment 19±5%, p<0.01) while⁶⁷Ga lung scans improved in 8 of the 10 patients. Pulmonary function tests showed improvement of the parameters studied (+7.5±2.1% mean change in vital capacity, +4.7±1.6% mean change in total lung capacity, +5.4±2% mean change in forced expiratory volume in one second and +6.2±1.5% mean change in diffusing capacity). In addition none of the treated patients deteriorated functionally and 9 of the 10 patients improved more than 10% in at least one parameter. These results indicate that daily oral prednisone therapy is effective in suppressing the alveolitis in pulmonary sarcoidosis and that it is able to preserve lung functions in patients who, without treatment, would be likely to deteriorate. Supported by C.N.R. grants n^o 82.00200.04 and 82.02057.56     

How Reliable Are Textured Implants Used in Breast Surgery? A Review of 510 Implants

Five hundred ten implants were used in 273 patients. The follow-up was between 3 months and 8 years. Four hundred nineteen prostheses were used for subglandular breast augmentation, 91 for subpectoral breast reconstruction. All the breasts were checked personally: 397 augmented breasts and 86 reconstructed breasts—94.7%. The objective criterion was the Baker classification: grades I and II, good result; and grades III and IV, poor result. Results were as follows: Baker I, 397 breasts; Baker II, 78 breasts (I + II, 98.3%); Baker III, 5 breasts; Baker IV, 3 breasts (III + IV, 1.7%). Three prostheses were removed after 3, 4, and 6 years because the textured surface was totally damaged. Two bilumen prostheses lost the saline fluid. The complication rate due to the implants was very low.