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51.
Amorim dos Santos Juliana Normando Ana Gabriela Costa de Toledo Isabela Porto Melo Gilberto De Luca Canto Graziela Santos-Silva Alan Roger Guerra Eliete Neves Silva 《Clinical oral investigations》2020,24(1):37-45
Clinical Oral Investigations - To evaluate therapeutic effects of laser therapy on patients with recurrent aphthous stomatitis assessing evidences from previously published systematic reviews. An... 相似文献
52.
53.
The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated
to be a contributing factor. This study compares the arrhythmogenic potential of six positive inotropic agents representing
different mechanistic classes: the β-adrenergic agonist dobutamine, the adenylyl cyclase activator forskolin, the phosphodiesterase-III
inhibitor milrinone, the cardiac glycoside ouabain, and the sodium channel agonists DPI 201-106 and BDF 9148. These agents
were studied in dogs with anterior myocardial infarction using lower and higher dose i. v. regimens targeted to elicit 20–40%
and 70–90% increases in LV+dP/dt, respectively. Precipitation of new ventricular arrhythmia by programmed ventricular stimulation
was observed in all treatment groups. Incidences of new arrhythmia were comparable in the lower dose regimens, ranging from
16.7% (3/18 animals with BDF 9148) to 31.6% (6/19 animals with DPI 201-106), and in the higher dose regimens, ranging from
10.0% (1/10 animals with milrinone) to 27.7% (5/18 animals with DPI 201-106). The overall incidence of new ventricular arrhythmia
ranged from 27.3% (3/11 animals with ouabain) to 47.4% (9/19 animals with DPI 201-106). No differences were observed in underlying
infarct size or time from infarction to electrophysiologic study between subgroups of animals in which new arrhythmias were
precipitated vs. those remaining non-responsive in any treatment group. The positive inotropic agents tested displayed diverse
total group effects on heart rate, electrocardiographic intervals including QTc and ventricular refractoriness. Within individual
treatment comparisons revealed a general but not universal pattern of greater ventricular refractory period values in newly
inducible vs. non-inducible subgroups in the DPI 201-106, BDF 9148 and ouabain (low and high dose); milrinone and dobutamine
(high dose) treatment groups. These findings indicate that regardless of underlying cellular mechanisms of action, the six
positive inotropic agents tested all displayed comparable proarrhythmic potentials unrelated to underlying infarct size and
time from infarction. This observation suggests the general shared property of increased myocardial contractility, potentially
adversely affecting myocardial oxygen balance, myocardial perfusion and electrical stability in the setting of previous myocardial
infarction, to be a common underlying cause for arrhythmogenesis. Additionally, alterations in ventricular refractoriness
and repolarization may contribute significantly to proarrhythmia with some positive inotropic interventions.
Received: 20 July 1999, Returned for 1. revision: 16 September 1999, 1. Revision received: 26 October 1999, Returned for 2.
revision: 24 November 1999, 2. Revision received: 22 December 1999, Accepted: 6 January 2000 相似文献
54.
Randomized Clinical Trial of Four Adhesion Strategies in Posterior Restorations—18‐Month Results 下载免费PDF全文
Flávia B. Delbons DDS MS PhD Jorge Perdigão DMD MS PhD Edson Araujo DDS MS PhD Charles A. Melo Freire DDS Danilo D. Caldas DDS MS PhD Jorge L. Cardoso DDS Margarida Pagani DDS Gilberto A. Borges DDS MS PhD Rodrigo B. Lima DDS 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》2015,27(2):107-117
55.
Gilberto Sabino-Santos Jr Felipe Gon?alves Motta Maia Thallyta Maria Vieira Renata de Lara Muylaert Sabrina Miranda Lima Cristieli Barros Gon?alves Patricia Doerl Barroso Maria Norma Melo Colleen B. Jonsson Douglas Goodin Jorge Salazar-Bravo Luiz Tadeu Moraes Figueiredo 《The American journal of tropical medicine and hygiene》2015,93(2):404-406
Hantaviruses are zoonotic viruses harbored by rodents, bats, and shrews. At present, only rodent-borne hantaviruses are associated with severe illness in humans. New species of hantaviruses have been recently identified in bats and shrews greatly expanding the potential reservoirs and ranges of these viruses. Brazil has one of the highest incidences of hantavirus cardiopulmonary syndrome in South America, hence it is critical to know what is the prevalence of hantaviruses in Brazil. Although much is known about rodent reservoirs, little is known regarding bats. We captured 270 bats from February 2012 to April 2014. Serum was screened for the presence of antibodies against a recombinant nucleoprotein (rN) of Araraquara virus (ARAQV). The prevalence of antibody to hantavirus was 9/53 with an overall seroprevalence of 17%. Previous studies have shown only insectivorous bats to harbor hantavirus; however, in our study, of the nine seropositive bats, five were frugivorous, one was carnivorous, and three were sanguivorous phyllostomid bats.Hantaviruses (family Bunyaviridae) are present throughout the globe in rodents, bats, and shrews.1 Humans exposed to rodent excreta from hantaviral reservoirs may develop life-threatening diseases. However, none of the other reservoirs are associated with human illness presently.1,2 Bats (order Chiroptera) are known to harbor a broad diversity of emerging zoonotic pathogens.2 Their ability to fly and social behavior favors maintenance, evolution, and spread of pathogens.1,2 The prevailing hypothesis has been that hantaviruses have coevolved with their rodent reservoirs over millions of years.1,3 With the recognition of new species of hantavirus in bats in Africa and Asia,4 Guo and others5 hypothesized that hantaviruses originated primarily in bats and then spilled over into rodents and shrews, but it seems that shrews are the original hosts from which the viruses jumped into both rodents and bats.3 To determine if New World bats in Brazil may harbor hantaviruses, we screened bat sera for antibodies that react against the recombinant nucleoprotein (rN) of Araraquara hantavirus (ARAQV).Bats were collected at five ecologically distinct sites in the northeast region of São Paulo state (sites 1–3) and north region of Minas Gerais state (sites 4 and 5), southeastern Brazil (Figure 1
and 9 and one specimen per species by trap-night was anesthetized to collect blood by cardiac puncture; blood samples were stored in cryovials and flash-frozen in liquid nitrogen. At sites 4 and 5, five specimens per trap-night were randomly selected for blood collection. All bats were handled and sampled according to Sikes and others10 guidelines. This research project, along with its procedures and protocols, is in accordance with Brazilian environment and wildlife protection laws and regulations, and have been approved by the Chico Mendes Institute of Biodiversity Conservation (Ministry of Environment, Brasília, Distrito Federal, Brazil.), protocols nos. 19838-1 and 41709-3. It has also been approved by the Ethics Committee for Animal Research of University of São Paulo and Federal University of Minas Gerais (nos. 020/2011 and 333/2013, respectively). From 270 captured bats, 53 were bled for detection of immunoglobulin G (IgG) antibodies to rN-ARAQV by indirect enzyme-linked immunosorbent assay (ELISA) using anti-bat (Bethyl Laboratories, Inc., Montgomery, TX) secondary antibody. This ELISA, as previously described, showed 97.2% sensitivity, 100% specificity, 100% positive predictive value, and 98.1% negative predictive value when compared with an IgG-ELISA using rN antigen of Andes virus, which is the serological test for hantavirus most used in South America.11,12Open in a separate windowFigure 1.Study areas, highlighting the states of São Paulo and Minas Gerais in southeastern Brazil. The map shows cities where bats have been captured.
Open in a separate windowJES = Jatai Ecological Station; LGEP = Lapa Grande Ecological Park; MG = Minas Gerais state; NEF = Nova Esperança Farm; SEP = Sapucai Ecological Park; SGF = Santa Gabriela Farm; SP = Sao Paulo state.*Cerrado = Brazilian savanna-like biome.†Dry forest = deciduous seasonal forest.Nine bats had IgG antibodies to ARAQV, which represents an overall seroprevalence of 17%. Five of these bats were from São Paulo state and four were from Minas Gerais state. Of these, five were frugivorous, one was carnivorous, and three were sanguivorous (Family Species Captured Infected/tested Main feeding items Phyllostomidae Artibeus lituratus 41 1/6 Fruits Phyllostomidae A. obscurus 2 1/2 Fruits Phyllostomidae A. planirostris 41 1/3 Fruits Phyllostomidae Carollia perspicillata 43 1/10 Fruits and insects Phyllostomidae Chiroderma villosum 1 1/1 Fruits Phyllostomidae Chrotopterus auritus 1 1/1 Small vertebrates Phyllostomidae Desmodus rotundus 11 3/5 Mammals blood Phyllostomidae Glossophaga soricina 22 0/5 Nectar and pollen Phyllostomidae Lonchophylla spp. 1 0/1 Nectar and pollen Phyllostomidae Micronycteris minuta 1 0/1 Insects Molossidae Molossops neglectus 1 0/1 Insects Molossidae Molossops temminckii 2 0/1 Insects Vespertilionidae Myotis nigricans 13 0/5 Insects Vespertilionidae Myotis albescens 4 0/1 Insects Phyllostomidae Platyrrhinus lineatus 23 0/4 Fruits Phyllostomidae Sturnira lilium 38 0/6 Fruits
Table 1
Trap sites general features6Trap sites/altitude (m) | City/state | Main vegetation | Secondary vegetation | Features | |
---|---|---|---|---|---|
1 | JES/600 | Luis Antonio/SP | Cerrado* | Semideciduous forest | Continuous Cerrado |
2 | NEF/775 | Cajuru/SP | Grassland | Cerrado | Monocultures |
3 | SGF/860 | Batatais/SP | Sugarcane | Cerrado | Monocultures |
4 | SEP/872 | Montes Claros/MG | Dry forest†7 | Cerrado | Karst topography |
5 | LGEP/1,009 | Montes Claros/MG | Cerrado8 | Gallery forest | Caves and shelters |