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41.
C Ferreli VI Sulica N Aste L Atzori M Pinna P Biggio 《Journal of the European Academy of Dermatology and Venereology》2003,17(4):443-445
BACKGROUND: Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity often associated with drug-induced coma. SUBJECT: We report a case with clinical and histopathologic findings characteristic of blisters and sweat gland necrosis occurring in a non-comatose patient. CONCLUSIONS: Skin blisters with underlying sweat gland necrosis is an entity previously reported to occur in comatose patients, our findings open new questions about the role of the drugs in the pathogenesis of those conditions. 相似文献
42.
Atrial Rate‐Responsive Pacing and Incidence of Sustained Atrial Arrhythmias in Patients with Implantable Cardioverter Defibrillators 下载免费PDF全文
ADOLFO FONTENLA M.D. Ph.D. RAFAEL SALGUERO M.D. JOSE B. MARTINEZ‐FERRER M.D. ANIBAL RODRIGUEZ M.D. JAVIER ALZUETA M.D. Ph.D. ENRIQUE GARCIA M.D. NURIA BASTERRA M.D. RAFAEL ROMERO M.D. JOAQUIN FERNANDEZ DE LA CONCHA M.D. XAVIER VIÑOLAS M.D. Ph.D. JULIAN VILLACASTIN M.D. Ph.D. MARIA LOPEZ‐GIL M.D. FERNANDO ARRIBAS M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(6):548-556
43.
VICENTE BERTOMEU‐GONZÁLEZ M.D. Ph.D. JOSÉ MORENO‐ARRIBAS M.D. JESÚS CASTILLO‐CASTILLO M.D. JOSÉ MARTÍNEZ‐FERRER M.D. Ph.D. XAVIER VIÑOLAS M.D. Ph.D. ANÍBAL RODRÍGUEZ M.D. Ph.D. ERNESTO DÍAZ‐INFANTE M.D. Ph.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. Ph.D. JAVIER ALZUETA M.D. Ph.D. ADOLFO FONTENLA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(1):73-80
44.
A practical method for non-experts in assessing exposure to risk factors for work-related
musculoskeletal disorders (WMSDs) is presented. Evaluación del Riesgo Individual
(Individual Risk Assessment) (ERIN) is based on available ergonomic tools, epidemiological
evidence and the joint IEA-WHO project for developing WMSDs risk management in developing
countries. ERIN focuses primarily on the interaction of some physical workplace factors
but also includes the workers’ assessment. A scoring system has been proposed to indicate
the level of intervention required to reduce the risk of injury. A worksheet has also been
designed for increasing the usability of the method. Preliminary tests show that it is
easy and quick to use, but further work is needed to establish its reliability and
validity. The use of ERIN can contribute to the prevention of WMSDs in Cuba and other
developing countries. 相似文献
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INTRODUCTION: Governing bodies for medical education recommend that spirituality and medicine be incorporated into training. AIM: To pilot a workshop on spirituality and medicine on a convenience sample of preclinical medical students and internal medicine residents and determine whether content was relevant to learners at different levels, whether preliminary evaluation was promising, and to generate hypotheses for future research. SETTING: Private medical school and university primary care internal medicine residency program, both in the Northeast. CURRICULUM DESCRIPTION: The authors designed and implemented a required 2-hour workshop for all second-year medical students and a separate required 1.5-hour workshop for all primary care internal medicine house staff. The workshops used multiple educational strategies including lecture, discussion, and role-play to address educational objectives. PROGRAM EVALUATION: Learners completed optional, anonymous pre and postworkshop surveys with six 5-point Likert-rated statements and space to cite the most useful part of the curriculum and their remaining questions. One hundred and thirty-seven learners participated and 100 completed both surveys. Medical students and residents had increased (all P< or =.002): agreement regarding the appropriateness of inquiring about spiritual and religious beliefs in the medical encounter, their perceived competence in taking a spiritual history, and their perceived knowledge of available pastoral care resources. Medical students, but not residents, had an increase in their perceived comfort in working with hospital chaplains. DISCUSSION: A brief pilot workshop on spirituality and medicine had a modest effect in improving attitudes and perceived competence of both medical students and residents. 相似文献
48.
Harmatz P Giugliani R Schwartz IV Guffon N Teles EL Miranda MC Wraith JE Beck M Arash L Scarpa M Ketteridge D Hopwood JJ Plecko B Steiner R Whitley CB Kaplan P Yu ZF Swiedler SJ Decker C;MPS VI Study Group 《Molecular genetics and metabolism》2008,94(4):469-475
The objective of this study was to evaluate the long-term clinical benefits and safety of recombinant human arylsulfatase B (rhASB) treatment of mucopolysaccharidosis type VI (MPS VI: Maroteaux-Lamy syndrome), a lysosomal storage disease. Fifty-six patients derived from 3 clinical studies were followed in open-label extension studies for a total period of 97–260 Weeks. All patients received weekly infusions of rhASB at 1 mg/kg. Efficacy was evaluated by (1) distance walked in a 12-minute walk test (12MWT) or 6-minute walk test (6MWT), (2) stairs climbed in the 3-minute stair climb (3MSC), and (3) reduction in urinary glycosaminoglycans (GAG). Safety was evaluated by compliance, adverse event (AE) reporting and adherence to treatment. Results: A significant reduction in urinary GAG (71–79%) was sustained. For the 12MWT, subjects in Phase 2 showed improvement of 255 ± 191 m (mean ± SD) at Week 144; those in Phase 3 Extension demonstrated improvement from study baseline of 183 ± 26 m (mean ± SE) in the rhASB/rhASB group at Week 96 and from treatment baseline (Week 24) of 117 ± 25 m in the placebo/rhASB group. The Phase 1/2 6MWT and the 3MSC from Phase 2 and 3 also showed sustained improvements through the final study measurements. Compliance was 98% overall. Only 560 of 4121 reported AEs (14%) were related to treatment with only 10 of 560 (2%) described as severe. Conclusion: rhASB treatment up to 5 years results in sustained improvements in endurance and has an acceptable safety profile. 相似文献
49.
The breakdown of senescent or defective red blood cells releases red cell contents, especially haemoglobin, which scavenges nitric oxide (NO) and decomposes to haem and free iron. These are potent oxidants, all of which have promoted the evolution of inducible and vasculoprotective compensatory pathways to rapidly clear and detoxify haemoglobin, haem and iron. Chronic haemolytic red cell disorders as diverse as sickle cell disease, thalassaemia, unstable haemoglobinopathy, cytoskeletal defects and enzymopathies have been linked to a clinical constellation of pulmonary hypertension, priapism, leg ulceration and possibly cerebrovascular disease and thrombosis. Besides free haemoglobin, haemolysis has been associated with extracellular arginase that limits substrate availability to NO synthase, endogenous inhibitors of NO synthase activity, and inappropriate activation of haemostatic pathways. This article reviews the haemolytic disorders that have been reported to manifest vascular complications, and explores the speculative possibility that haemolysis mediates some of the vascular complications of inflammation and diabetes. 相似文献
50.
Complex situations related to the environment, as in the regions affected by the Chernobyl accident and regions in which nuclear weapons testing were undertaken, as in Semipalatinsk, could be reflected in the trace element content in mothers' milk. The evaluation of fractional transfer to milk of ingested or inhaled activity and of the corresponding dose coefficients for the infant, following a mothers' radioactive intake, can take advantage from wide-ranging studies of elemental and radionuclide contents in mothers' milk. In this work the possibility to determine elements, such as Ru, Zr, Nb, Te, Ce, Th, U, in milk powder has been investigated. Although results from elemental analyses of breast milk are to be found in the literature, the determination of the identified elements has attracted poor attention since they are not considered essential elements from a biological point of view. Nevertheless, in the case of radioactive releases to the environment, such data could be of interest in evaluation of dose to the breast-fed infant. 相似文献