全文获取类型
收费全文 | 3720篇 |
免费 | 180篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 79篇 |
儿科学 | 73篇 |
妇产科学 | 80篇 |
基础医学 | 491篇 |
口腔科学 | 69篇 |
临床医学 | 349篇 |
内科学 | 947篇 |
皮肤病学 | 24篇 |
神经病学 | 609篇 |
特种医学 | 118篇 |
外科学 | 377篇 |
综合类 | 8篇 |
一般理论 | 2篇 |
预防医学 | 173篇 |
眼科学 | 35篇 |
药学 | 219篇 |
中国医学 | 15篇 |
肿瘤学 | 256篇 |
出版年
2023年 | 30篇 |
2022年 | 65篇 |
2021年 | 94篇 |
2020年 | 59篇 |
2019年 | 83篇 |
2018年 | 105篇 |
2017年 | 75篇 |
2016年 | 107篇 |
2015年 | 99篇 |
2014年 | 149篇 |
2013年 | 182篇 |
2012年 | 270篇 |
2011年 | 243篇 |
2010年 | 155篇 |
2009年 | 138篇 |
2008年 | 251篇 |
2007年 | 247篇 |
2006年 | 236篇 |
2005年 | 249篇 |
2004年 | 230篇 |
2003年 | 200篇 |
2002年 | 195篇 |
2001年 | 34篇 |
2000年 | 21篇 |
1999年 | 31篇 |
1998年 | 57篇 |
1997年 | 29篇 |
1996年 | 16篇 |
1995年 | 32篇 |
1994年 | 19篇 |
1993年 | 18篇 |
1992年 | 17篇 |
1991年 | 11篇 |
1990年 | 21篇 |
1989年 | 13篇 |
1988年 | 9篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 13篇 |
1984年 | 15篇 |
1983年 | 8篇 |
1982年 | 15篇 |
1981年 | 6篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1976年 | 4篇 |
1974年 | 8篇 |
1973年 | 4篇 |
1970年 | 3篇 |
排序方式: 共有3924条查询结果,搜索用时 15 毫秒
101.
Carmen Barba Massimo Cossu Renzo Guerrini Giancarlo Di Gennaro Flavio Villani Luca De Palma Laura Grisotto Alessandro Consales Domenica Battaglia Nelia Zamponi Piergiorgio dOrio Martina Revay Michele Rizzi Sara Casciato Vincenzo Esposito Pier Paolo Quarato Roberta Di Giacomo Giuseppe Didato Chiara Pastori Giusy Carfi Pavia Simona Pellacani Giulia Matta Mattia Pacetti Gianpiero Tamburrini Elisabetta Cesaroni Gabriella Colicchio Giampaolo Vatti Sofia Asioli Massimo Caulo Carlo Efisio Marras Laura Tassi 《Epilepsia》2021,62(1):128-142
102.
Edoardo Conte Daniele Andreini Marco Magnoni Serge Masson Saima Mushtaq Sergio Berti Mauro Canestrari Giancarlo Casolo Domenico Gabrielli Roberto Latini Paolo Marraccini Tiziano Moccetti Maria Grazia Modena Gianluca Pontone Marco Gorini Aldo P. Maggioni Attilio Maseri 《Journal of Cardiovascular Computed Tomography》2021,15(1):73-80
BackgroundHigh-risk coronary atherosclerosis features evaluated coronary CT angiography (CCTA) were suggested to have a prognostic role. The present study aimed to evaluate the association of circulating biomarkers with high-risk plaque features assessed by CCTA.MethodsA consecutive cohort of subjects who underwent CCTA because of suspected CAD was screened for inclusion in the CAPIRE study. Based on risk factors (RF) burden patients were defined as having a low clinical risk (0–1 RF with the exclusion of patients with diabetes mellitus as single RF) or an high clinical risk (≥3 RFs). In all patients, measurement of inflammatory biomarkers and CCTA analysis focused on high-risk plaque features were performed. Univariate and multivariate logistic regression analysis were used to evaluate the relationship between clinical and biological variables with CCTA advanced plaque features.Results528 patients were enrolled in CAPIRE study. Older age and male sex appeared to be predictors of qualitative high-risk plaque features and associated with the presence of elevated total, non-calcified and low-attenuation plaque volume. Among circulating biomarkers only hs-CRP was found to be associated with qualitative high-risk plaque features (OR 2.02, p = 0.004 and 2.02, p = 0.012 for LAP and RI > 1.1, respectively) with borderline association with LAP-Vol (OR 1.52, p = 0.076); HbA1c and PTX-3 resulted to be significantly associated with quantitative high-risk plaque features (OR 1.71, p = 0.003 and 1.04, p = 0.002 for LAP-Vol, respectively).ConclusionsOur results support the association between inflammatory biomarkers (hs-CRP, PTX- 3), HbA1c and high-risk atherosclerotic features detected by CCTA. Male sex and older age are significant predictors of high-risk atherosclerosis. 相似文献
103.
Iván Cosamalón-Gan Tatiana Cosamalón-Gan Giancarlo Mattos-Piaggio Vega Villar-Suárez José García-Cosamalón José Antonio Vega-Álvarez 《Neurocirugía (Asturias, Spain)》2021,32(1):21-35
Up until fairly recently, it was thought that sciatic pain in the lumbar herniated disc was caused by compression on the nerve root. However, the lumbar herniated disc shows mixed pictures which are difficult to explain by simple mechanical compromise. In recent years various immunology, immunohistochemistry and molecular biology studies have shown that the herniated tissue is not an inert material, but rather it Is biologically very active with the capability of expressing a series of inflammatory mediators: cytokines such as interleukin-1, interleukin-6, interleuquin-8 and tumor necrosis factor being the ones which stand out. The inflammation is not only induced by the chemical irritation of the bioactive substances released by the nucleus pulposus but also by an autoimmune response against itself. Thus, in addition to the mechanical factor, the biomechanical mediation plays an important role in the pathophysiology of sciatic pain and of radiculopathy. Through a review of a wide range of literature, we researched the cellular molecular mediators involved in this inflammatory process around the lumbar herniated disc and its involvement in sciatic pain. 相似文献
104.
105.
Paola Stefanelli Antonino Bella Giorgio Fedele Serena Pancheri Pasqualina Leone Paola Vacca Arianna Neri Anna Carannante Cecilia Fazio Eleonora Benedetti Stefano Fiore Concetta Fabiani Maurizio Simmaco Iolanda Santino Maria Grazia Zuccali Giancarlo Bizzarri Rosa Magnoni Pier Paolo Benetollo Antonio Ferro 《Clinical microbiology and infection》2021,27(4):633.e1-633.e7
ObjectivesA seroprevalence study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was conducted in a high-incidence area located in northeastern Italy.MethodsAll citizens above 10 years of age resident in five municipalities of the Autonomous Province of Trento, with the highest incidence of coronavirus disease 2019 (COVID-19) cases, were invited to participate in the study. Among 6098 participants, 6075 sera and a standardized questionnaire administered face-to-face were collected between 5 May and 15 May 2020 and examined. Symptomatic individuals and their family contacts were tested by RT-PCR. Anti-SARS-CoV-2 antibodies were detected using an Abbott SARS-CoV-2 IgG assay, which was performed on the Abbott Architect i2000SR automated analyser. Seroprevalence was calculated as the proportion of positive results among the total number tested. A multivariable logistic regression model was performed to assess the relationship between seropositive versus seronegative individuals for a set of explanatory variables.ResultsA total of 1402 participants were positive for IgG antibodies against SARS-CoV-2, with a prevalence of 23.1% (1402/6075). The highest prevalence was found in the age class 40–49 years. Overall, 34.4% (2096/6098) of the participants reported at least one symptom. The ratio between reported cases identified by molecular test and those with seropositive results was 1:3, with a maximum ratio of about 1:7 in the age group <20 years and a minimum around 1:1 in those >70 years old. The infection fatality rate was 2.5% (35/1402). Among the symptoms, anosmia and ageusia were strongly associated with seropositivity.ConclusionsThe estimated seroprevalence of 23% was three-fold higher than the number of cases reported in the COVID-19 Integrated Surveillance data in the study area. This may be explained in part by a relatively high number of individuals presenting mild or no illness, especially those of younger age, and people who did not seek medical care or testing, but who may contribute to virus transmission in the community. 相似文献
106.
107.
Paciocco G Uslenghi E Bianchi A Mazzarella G Roviaro GC Vecchi G Harari S 《Chest》2004,125(1):135-142
BACKGROUND: High-resolution CT (HRCT) scanning plays an important role in the diagnosis of diffuse cystic lung diseases (DCLDs). However, its role in the clinical evaluation of patients affected by DCLD has not yet been well-clarified. At present, pulmonary function tests are the only methods available for the evaluation of lung impairment due to these diseases, but their sensitivity and reliability are still limited. PURPOSE: The aim of this study was to correlate the quantitative score of cystic-aerial lesions obtained by a HRCT density mask (DM) software with pulmonary function data in DCLDs. METHODS: Spirometry, lung volumes, diffusion capacity, arterial blood gas (ABG) analysis, 6-min walking test (6-MWT), and HRCT with DM quantitative evaluation were performed in a cohort of 25 patients (lymphangioleiomyomatosis [LAM], 13 patients; Langerhans cells histiocytosis [LCH], 12 patients). Linear regression was used for the statistical analysis. The sum and mean of the air-trapping percentages at three different levels of DM study (ie, aortic arch, left lower lobe bronchus origin, and 2 cm from the diaphragmatic muscle), and various functional parameters and exercise performance values were matched for the analysis. RESULTS: An obstructive pattern was present in 13 patients (52%; LCH group, 8 patients; LAM group, 5 patients). A predominant restrictive pattern was detected only in three patients (12%; LCH group, two patients; LAM group, one patient). Nine patients (36%) walked < 350 m, and 14 of 23 patients (61%) had a significant decrease in arterial oxygen saturation during exercise (> 4 U). The results of DM quantitative study (sum and mean) significantly correlated with FVC (r = - 0.56; p < 0.001), FEV(1)/vital capacity (r = - 0.94; p < 0.002), midexpiratory phase of forced expiratory flow (r = - 0.84; p < 0.05), FEV(1) (r = - 0.82; p < 0.05), and diffusing capacity of the lung for carbon monoxide (r = - 0.82; p < 0.05), bronchial airway resistance (r = 0.79; p < 0.05), and distance walked on the 6-MWT (r = - 0.53; p < 0.05). No significant correlation was found with the results of ABG analysis. CONCLUSIONS: In DCLDs, HRCT scans with quantitative assessment performed by a DM software showed a very good correlation with functional parameters. Therefore, DM could be considered, in combination with a complete functional assessment, in the initial evaluation of patients affected by DCLDs. However, further studies are needed to assess its usefulness in the follow-up of these patients. 相似文献
108.
Enrico Papini Rinaldo Guglielmi Giancarlo Bizzarri Filomena Graziano Antonio Bianchini Claudia Brufani Sara Pacella Dario Valle Claudio M Pacella 《Thyroid》2007,17(3):229-235
AIM OF THE STUDY: To compare clinical and ultrasound (US) changes induced in cold thyroid nodules by US-guided percutaneous laser ablation (PLA) versus follow-up or levothyroxine (LT4) suppressive therapy. METHODS: 62 patients randomly assigned to a single PLA (Group 1), LT4 (Group 2), or follow-up (Group 3). Entry criteria: euthyroid patients with a solid thyroid nodule >5 mL and benign cytological findings. TREATMENT: Group 1: PLA was performed with a 1.064 mum neodymium yttrium-aluminum-garnet laser with output power of 3 W for 10 minutes; Group 2: the LT4 dose was adjusted to induce thyrotropin suppression; Group 3: no treatment. RESULTS: In Group 1 a significant nodule reduction was found 6 and 12 months after PLA (delta volume: -42.7 +/- 13.6%; p = 0.001). A reduction >50% was found in 33.3% of cases. In Group 2 a nonsignificant nodule shrinkage was observed. A nonsignificant volume increase was observed in Group 3. Improvement of local symptoms was registered in 81.2% of patients in Group 1 vs. 13.3% in Group 2 and 0.0% in Group 3 ( p = 0.001). No complications were noted. CONCLUSIONS: A single PLA induced significant volume reduction and improvement of local symptoms. PLA was more effective than LT4. Follow-up was associated with nodule growth and progression of local symptoms. PLA should be considered a potential mini-invasive alternative to surgery in symptomatic patients with benign cold thyroid nodules. 相似文献
109.
Luca Masotti Grazia Panigada Giancarlo Landini Filippo Pieralli Francesco Corradi Salvatore Lenti Rino Migliacci Stefano Arrigucci Anna Frullini Maria Chiara Bertieri Stefano Tatini Alberto Fortini Irene Cascinelli Nicola Mumoli Stefano Giuntoli Alessandro De Palma Veronica De Crescenzo Michele Piacentini Giancarlo Tintori Alba Dainelli Giuseppa Levantino Plinio Fabiani Filippo Risaliti Roberta Mastriforti Michele Voglino Valentina Carli Simone Meini 《Journal of thrombosis and thrombolysis》2016,41(4):606-612
Prognostic stratification of acute pulmonary embolism (PE) remains a challenge in clinical practice. Simplified PESI (sPESI) score is a practical validated score aimed to stratify 30-day mortality risk in acute PE. Whether prognostic value of sPESI score differs according to sex has not been previously investigated. Therefore the aim of our study was to provide information about it. Data records of 452 patients, 180 males (39.8 %) and 272 females (60.2 %) discharged for acute PE from Internal Medicine wards of Tuscany (Italy) were analysed. sPESI was retrospectively calculated. Variables enclosed in sPESI score, all cause in-hospital mortality and overall bleedings were compared between sexes. Moreover, predictive ability of sPESI score as prognosticator of all cause in-hospital mortality was tested and compared between sexes. sPESI score 0 (low risk) was found in 17.7 % of males and 13.6 % of females (p = 0.2323). We didn’t find significant difference in sPESI scoring distribution. Age ≥80 years (51.4 vs. 33.8 %, p = 0.0003) and heart rate ≥110 bpm (23.5 vs. 14.4 %, p = 0.0219) were found significantly more prevalent in females, whereas active cancer (23.8 vs. 39.4 %, p = 0.0004) and cardio-respiratory diseases (19.8 vs. 27.7 %, p = 0.0416) were in males. All cause in-hospital mortality was 0 % in both genders for sPESI score 0, whereas it was 5.4 % in females and 13.6 % in males with sPESI score 1–2 (p = 0.0208) and 22 % in females and 19.3 % in males with sPESI score ≥3 (p = 0.7776). Overall bleedings were significantly more frequent in females compared with males (4.77 vs. 0.55 %, p = 0.0189). In females overall bleedings ranged from 2.7 % in sPESI score 0 to 6 % in sPESI score ≥3. Predictive ability of sPESI score as prognosticator of all cause in-hospital mortality was higher in females compared to males (AUC 0.72 vs. 0.67, respectively). In real life different co-morbidity burdens in females compared to males. Females seems to be at lower risk of all cause in-hospital mortality for sPESI score ≤2 but at higher risk of bleeding, irrespective from sPESI scoring. Predictive ability of sPESI score seems better in females. 相似文献