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41.
Chiappe C De Rubertis A Piegari G Amato G Gervasi PG 《Chemical research in toxicology》2003,16(1):56-65
The stereochemical course of the biotransformation of 1,2-monoepoxides of 4-vinylcyclohexene (2 and 3) by liver microsomes from control and induced rats and by purified P4502B1 and P4502E1 has been determined. The epoxidation of monoexpodies cis-4-vinylcyclohexene 1,2-epoxide (2) and trans-4-vinylcyclohexene 1,2-epoxide (3) gives the corresponding eight isomeric diepoxides cis-4-vinylcyclohexene diepoxide (9) and trans-4-vinylcyclohexene diepoxide (10). The stereoselectivity of this process is affected by P450 induction. Phenobarbital is able to enhance the yield of epoxidation to give preferentially diepoxide (1R, 2S, 4R, 7R)-trans-10b. This enantiomer is also formed as nearly the sole product by P450-catalyzed epoxidation of (1R,2S,4R)-trans-3b, the monoepoxide that, as a consequence of the selective formation from 4-vinylcyclohexene and/or reduced elimination by epoxide hydrolase, tends to accumulate in rat. Also, the P4502B1 but not 2E1, in a reconstituted system, is able to perform the epoxidation of (1R,2S,4R)-trans-3b to produce selectively the same diepoxide. Diepoxides cis-9 and trans-10 are biotransformed by mEH catalyzed hydrolysis. Although the hydrolysis of diepoxides 9 is characterized by a lower substrate enantioselection, the reaction of diepoxides 10 occurs with a good substrate enantioselectivity favoring the hydrolysis of the epoxides (1R,2S,4R,7S)-trans-10b and (1S,2R,4S,7S)-trans-10a. Diepoxide (1R,2S,4R,7R)-trans-10b is therefore the isomer primarily formed by P450-catalyzed oxidation of monoepoxide trans-3, and it is also the compound showing the lower propensity to undergo mEH-catalyzed hydrolysis. On the basis of this result, the ovotoxicity of 4-vinylcyclohexene is expected to be due to the stereoisomer diepoxide (1R,2S,4R,7R)-trans-10b, whose biological reactivity, via cross-linking, may be strongly different to the other isomer diepoxides, being dependent by its specific conformation. 相似文献
42.
G Foglia-Manzillo F Giada S Beretta G Corrado M Santarone A Raviele 《The American journal of cardiology》1999,84(3):284-288
Head-up tilt testing (HUTT) potentiated with sublingual nitroglycerin has gained acceptance as means of diagnosing neurally mediated syncope. To evaluate the reproducibility of HUTT potentiated with sublingual nitroglycerin, 48 patients with unexplained syncope prospectively underwent 2 consecutive tests 1 to 28 days apart. The initial test ended in syncope in 34 patients (71%). In 9 patients (19%) the test was positive during the drug-free phase, whereas 25 patients (52%) had syncope after nitroglycerin administration. Of these 34 patients with an initial positive test result, 27 (79%) had a reproducible outcome on repeat testing. Of 12 patients (25%) with an initial negative test result, 10 (83%) had a reproducible outcome on repeat testing. Of 2 patients (4%) with a first test ending in exaggerated response, both had a negative repeat test response. The overall reproducibility of sublingual nitroglycerin tilt-table testing was 77%. In a group of 23 patients with both positive tests, 19 (83%) had the same response modality (2 vasodepressor, 4 cardioinhibitory, 13 mixed response). In the same group of patients, individual trough heart rates correlated well with each other between tests. Finally, in the 27 patients with both positive tests, intrapatient time of onset of symptoms did not significantly correlate between tests. Thus, in patients with syncope of unknown origin, HUTT potentiated with sublingual nitroglycerin provides an adequate reproducibility when repeated on different days. 相似文献
43.
We really appreciate Dr Jastrzebska-Maj et al.'s interest inour work, dealing with the diagnostic management of childrenwith unexplained syncope.1 Head-up tilt testing (HUT) potentiatedwith sublingual nitroglycerin (NTG) is an accepted examinationin 相似文献
44.
Tamara Ius Daniela Cesselli Miriam Isola Giovanni Toniato Giada Pauletto Giovanni Sciacca Sara Fabbro Enrico Pegolo Simona Rizzato Antonio Paolo Beltrami Carla di Loreto Miran Skrap 《Current treatment options in neurology》2018,20(2):3
Purpose of review
The purpose of this study was to retrospectively evaluate the use of carmustine wafers (CWs) in the management of high-grade gliomas (HGGs). The data from our monoinstitutional series was compared with studies reported in the literature. Special emphasis was placed on the evaluation of side effects and the analysis of extent of resection and molecular profile as risk factors.Recent findings
The implantation of CWs into the resection cavity during HGG treatment to deliver localized chemotherapy, followed by the Stupp protocol, remains debated in a clinical setting, largely due to the lack of appropriate phase III studies. Given the high expense and poorly characterized side effects associated with CW treatment, identification of patients most likely to benefit from this therapy could be clinically relevant.Summary
CWs may represent an effective and safe first-line treatment for patients with HGG that exhibit complete tumor resection and harboring a methylated MGMT promoter. Our investigation showed a much larger group of patients exhibiting long-term survival (>?=?36 months), strongly supporting a potential survival benefit conferred via CW treatment. The pre-surgical definition of the MGMT promoter status could be of clinical use in identifying “good responders” to CW implantation.45.
46.
Heart rate variability in untreated newly diagnosed temporal lobe epilepsy: Evidence for ictal sympathetic dysregulation 下载免费PDF全文
47.
Symptomatic and presumed symptomatic focal epilepsies in childhood: An observational,prospective multicentre study 下载免费PDF全文
Marilena Vecchi Carmen Barba Debora De Carlo Micol Stivala Renzo Guerrini Emilio Albamonte Domiziana Ranalli Domenica Battaglia Giada Lunardi Clementina Boniver Benedetta Piccolo Francesco Pisani Gaetano Cantalupo Giuliana Nieddu Susanna Casellato Silvia Cappanera Elisabetta Cesaroni Nelia Zamponi Domenico Serino Lucia Fusco Alessandro Iodice Filippo Palestra Lucio Giordano Elena Freri Ilaria De Giorgi Francesca Ragona Tiziana Granata Isabella Fiocchi Stefania Maria Bova Massimo Mastrangelo Alberto Verrotti Sara Matricardi Elena Fontana Davide Caputo Francesca Darra Bernardo Dalla Bernardina Francesca Beccaria Giuseppe Capovilla Maria Pia Baglietto Alessandra Gagliardi Aglaia Vignoli Maria Paola Canevini Egle Perissinotto Stefano Francione 《Epilepsia》2016,57(11):1808-1816
48.
49.
Roberto M. Tacchino Francesco Greco Daniele Matera Giada Diflumeri 《Obesity surgery》2010,20(8):1154-1160
Background
Single-incision laparoscopic surgery (SILS) has been developed with the aim of reducing the invasiveness of traditional laparoscopy. 相似文献50.