全文获取类型
收费全文 | 3954篇 |
免费 | 195篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 88篇 |
妇产科学 | 73篇 |
基础医学 | 366篇 |
口腔科学 | 119篇 |
临床医学 | 303篇 |
内科学 | 965篇 |
皮肤病学 | 53篇 |
神经病学 | 444篇 |
特种医学 | 164篇 |
外科学 | 911篇 |
综合类 | 4篇 |
预防医学 | 110篇 |
眼科学 | 106篇 |
药学 | 161篇 |
中国医学 | 2篇 |
肿瘤学 | 290篇 |
出版年
2024年 | 6篇 |
2023年 | 42篇 |
2022年 | 109篇 |
2021年 | 196篇 |
2020年 | 105篇 |
2019年 | 124篇 |
2018年 | 149篇 |
2017年 | 102篇 |
2016年 | 132篇 |
2015年 | 147篇 |
2014年 | 190篇 |
2013年 | 248篇 |
2012年 | 315篇 |
2011年 | 321篇 |
2010年 | 188篇 |
2009年 | 177篇 |
2008年 | 210篇 |
2007年 | 223篇 |
2006年 | 207篇 |
2005年 | 158篇 |
2004年 | 170篇 |
2003年 | 143篇 |
2002年 | 151篇 |
2001年 | 45篇 |
2000年 | 28篇 |
1999年 | 35篇 |
1998年 | 26篇 |
1997年 | 20篇 |
1996年 | 10篇 |
1995年 | 14篇 |
1994年 | 10篇 |
1993年 | 13篇 |
1992年 | 14篇 |
1991年 | 15篇 |
1990年 | 14篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 17篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1978年 | 5篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 9篇 |
1968年 | 5篇 |
1966年 | 5篇 |
排序方式: 共有4204条查询结果,搜索用时 15 毫秒
91.
92.
Daniela Rossi Marilù Tarantino Giacomo Rossino Marta Rui Markus Juza 《Expert opinion on drug discovery》2017,12(12):1253-1269
Introduction: Over the last 30 years, the scientific community has directed its efforts towards the identification of enantioselective approaches to obtain the desired active enantiomer. Accordingly, efficient production of single enantiomers from small to large scale, throughout Drug Discovery (DD) programs, has become of great interest and a fundamental challenge.Areas covered: This review focuses on two fundamental strategies for preparing enantiomers in high yields and with an excellent enantiomeric excess (ee). Separation of racemates, enantioselective synthesis procedures, and integrated approaches have been extensively reviewed, to offer a guide that enables the selection of the suitable methodology for producing pure enantiomers in scales from small to large.Expert opinion: Over the past two decades, drug regulatory agencies have set strict rules on the use of racemates and pure enantiomers, leading to the transformation of the drug market. Indeed, the number of drugs approved as a single enantiomer has exponentially increased, outclassing the racemic compounds. As a consequence, the academia and pharmaceutical companies are eager to develop efficient procedures for obtaining enantiopure compounds on the desired scale. 相似文献
93.
Di Pietro Martina Dono Fedele Consoli Stefano Evangelista Giacomo Pozzilli Valeria Calisi Dario Barbone Filomena Bonanni Laura Onofrj Marco De Angelis Maria Vittoria Sensi Stefano L. 《Neurological sciences》2022,43(5):2951-2956
Neurological Sciences - The coronavirus pandemic became the hard challenge for the modern global health system. To date, vaccination is the best strategy against Sars-Cov-2-related illness. About 3... 相似文献
94.
Tardivo Valentina Castaldi Antonio Baldino Giuseppe Siri Giacomo Bruzzo Mattia Del Sette Massimo Romano Nicola 《Neurological sciences》2022,43(1):459-465
Neurological Sciences - Vascular Eagle syndrome, due to impingement of the extracranial internal carotid artery (ICA) by the styloid process (SP), is an uncommon and not yet widely recognized cause... 相似文献
95.
Sebastiano Arnoldi Gabriella Roda Alessandro Coceanig Eleonora Casagni Lucia Dell’Acqua Fiorenza Farè Chiara Rusconi Lucia Tamborini Giacomo Luca Visconti Veniero Gambaro 《Forensic Toxicology》2016,34(2):411-418
In this paper, we describe the approach to the characterization of an unusual material seized by the judicial authority, near Brescia City in Northern Italy. Usual analyses such as thin-layer chromatography, gas chromatography (GC)–flame ionization detection, and GC/mass spectrometry (MS) did not show the presence of drugs of abuse, in particular amphetamine-like compounds. The major solid component was identified as cornstarch; then taking into account the strong aromatic scent of the seized material; a preliminary experiment for volatile organic compounds was carried out by headspace (HS)-GC/MS. This analysis tentatively evidenced the presence of 1-phenyl-2-propanone (P2P), an amphetamine precursor. Therefore, we developed and optimized a new analytical method for determination of P2P in seized materials by HS-GC/MS. We also synthesized P2P, with the permission of the Ministry of Health, to have it as reference standard, because of its being illegal and the difficulty in obtaining it. This case had some analogies with the cases referred to as “wet amphetamine” by the judicial authority, in which amphetamines are sold mixed with P2P. The possible use of the material could be the production of tablets made of cornstarch with an aromatic scent similar to that of amphetamines to deceive consumers and to sell them as a drug of abuse. 相似文献
96.
Patrizia Burra Eleonora De Martin Alberto Zanetto Marco Senzolo Francesco Paolo Russo Giacomo Zanus Stefano Fagiuoli 《Transplant international》2016,29(2):135-152
The hepatitis C virus (HCV) infects more than 180 million people globally, with increasing incidence, especially in developing countries. HCV infection frequently progresses to liver cirrhosis leading to liver transplantation or death, and HCV recurrence still constitutes a major challenge for the transplant team. Antiviral therapy is the only available instrument to slow down this process, although its actual impact on liver histology, in responders and nonresponders, is still controversial. We are now facing a “new era” of direct antiviral agents that is already changing the approach to HCV burden both in the pre‐ and in the post‐liver transplantation settings. Available data on sofosbuvir/ledipasvir and sofosbuvir/simeprevir in patients with decompensated cirrhosis sustain a SVR12 of 89% 1 , but one‐third of patients do not clinically improved. The sofosbuvir/ribavirin treatment in stable cirrhotic patients with HCC before liver transplantation is associated with 2% recurrence rate if liver transplantation is performed at least one month after undetectable HCV‐RNA is achieved. The treatment of recurrence with the new antiviral drugs is associated with a SVR that ranges between 60 and 90%. In this review, we have focused on the evolution of antiviral therapy for HCV recurrence from the “old” interferon‐based therapy to the “new” interferon‐free regimens, highlighting useful information to aid the transplant hepatologist in the clinical practice. 相似文献
97.
98.
Understanding the molecular mechanisms of influenza virus resistance to neuraminidase inhibitors is a main concern for their clinical use. In an attempt to reproduce in vivo selective conditions where influenza virus resistance to neuraminidase inhibitors can occur the zanamivir selection of an A/H1N1 influenza virus strain was carried out in Madin-Darby canine kidney cells performed in the presence or absence of sialic acid-containing inhibitor analogues that act as virus decoy receptors. The zanamivir-selected variants passaged in the presence of sialic acid-containing molecules resembling the human-like virus receptor lost the ability to bind red blood cells. Furthermore, whereas all zanamivir-selected variants exhibited a robust reduction in susceptibility to zanamivir in plaque assays only those obtained after extensive passages acquired a powerful neuraminidase enzyme resistance to zanamivir and oseltamivir. Evidence that balanced neuraminidase and hemagglutinin activities mediated by mutations induced during selection could play a role in the decrease of virus replication susceptibility to zanamivir is reported. 相似文献
99.
Querzola Giacomo Lovati Carlo Lagan Maria M. Pirastru Alice Baglio Francesca Pantoni Leonardo 《Neurological sciences》2022,43(9):5383-5390
Neurological Sciences - Chronic traumatic encephalopathy (CTE) is a degenerative disease caused by repetitive traumatic brain injury (TBI). Because CTE can be definitely diagnosed only post-mortem,... 相似文献
100.
Giacomo Corrado Liliana Mereu Stefano Bogliolo Vito Cela Barbara Gardella Isabella Sperduti Camilla Certelli Alice Pellegrini Giulia Posar Ashanti Zampa Saverio Tateo Angiolo Gadducci Arsenio Spinillo Enrico Vizza 《The international journal of medical robotics + computer assisted surgery : MRCAS》2020,16(2)