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991.
992.
Ginanneschi F Milani P Filippou G Mondelli M Frediani B Melcangi RC Rossi A 《Journal of molecular neuroscience : MN》2012,47(1):59-66
Growing evidence of neuroprotective and analgesic effects by progesterone (PROG) has been obtained in experimental animal
models of neuropathy. In this paper, we report the results of the first experimental study to test the efficacy of PROG in
a human neuropathy. The effects of a local administration of 17-alpha-hydroxyprogesterone caproate (17HPC) has been studied
in patients with carpal tunnel syndrome (CTS) and compared with those of a local administration of corticosteroid (CS) in
a analogous CTS group. Sixteen women affected by mild CTS were selected. Clinical, electrophysiological and ultrasonographic
data of the median nerve were quantified at 0 (pre-injection), 1 and 6 months after CS or 17HPC injection. One month after
injection, both 17HPC and CS groups exhibited similar reduction in pain scores, whereas only the 17HPC-treated group still
manifested symptoms relief 6 months after. Only in CS-treated patients, improvement of the clinical data correlated with ultrasonographic
and electrophysiological changes of the median nerve. The present study indicates that intra-carpal injection with a long-acting
PROG derivative is effective for relief of symptoms in CTS. This effect is apparently mediated by a mechanism distinct from
that of the CS. 相似文献
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Paul A Kaiser GM Molmenti EP Schroeder T Vernadakis S Oezcelik A Baba HA Cicinnati VR Sotiropoulos GC 《The American surgeon》2011,77(12):1695-1699
The Bismuth-Corlette (BC) classification is the current preoperative standard to assess hilar cholangiocarcinomas (HC). The aim of this study is to evaluate the accuracy, sensitivity, and prognostic value of the BC classification. Data of patients undergoing resection for HC were analyzed. Endoscopic retrograde cholangiography and standard computed tomography were undertaken in all cases. Additional 3D-CT-reconstructions, magnetic resonance imaging, and percutaneous transhepatic cholangiography were obtained in selected patients. A systematic review and meta-analysis of the literature was performed. Ninety patients underwent resection of the hilar bile duct confluence, with right or left hemihepatectomy in 68 instances. The overall accuracy of the BC classification was 48 per cent. Rates of BC under- and over-estimation were 29 per cent and 23 per cent, respectively. The addition of MRI, 3D-CT-reconstructions, or percutaneous transhepatic cholangiography improved the accuracy to 49 per cent (P = 1.0), 53 per cent (P = 0.074), and 64 per cent (P < 0.001), respectively. Lowest sensitivity rates were for BC Type IIIA/IIIB tumors. Meta-analysis of published BC data corresponding to 540 patients did not reach significance. The BC classification has low accuracy and no prognostic value in cases of HC undergoing resection. 相似文献
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999.
Dimitrakakis G von Oppell UO 《The Annals of thoracic surgery》2011,92(4):1553-1553; author reply 1554
1000.
Pohlemann T Stengel D Tosounidis G Reilmann H Stuby F Stöckle U Seekamp A Schmal H Thannheimer A Holmenschlager F Gänsslen A Rommens PM Fuchs T Baumgärtel F Marintschev I Krischak G Wunder S Tscherne H Culemann U 《Injury》2011,42(10):997-1002