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Maria‐Luisa Alegre 《American journal of transplantation》2019,19(10):2669-2669
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de Senna PN Ilha J Baptista PP do Nascimento PS Leite MC Paim MF Gonçalves CA Achaval M Xavier LL 《Metabolic brain disease》2011,26(4):269-279
Type 1 diabetes mellitus (T1DM) is associated with neurocognitive dysfunction and astrogliosis. Physical exercise prevents
cognitive impairments and induces important brain modifications. The aim of our study was to investigate the effect of treadmill
exercise on spatial memory and astrocytic function in the hippocampus of a T1DM model. Fifty-seven Wistar rats were divided
into four groups: trained control (TC) (n = 15), non-trained control (NTC) (n = 13), trained diabetic (TD) (n = 14) and non-trained diabetic (NTD) (n = 15). One month after streptozotocin-induced diabetes, exercise groups were submitted to 5 weeks of physical training, and
then, all groups were assessed in the novel object-placement recognition task. Locomotor activity was analyzed in the open
field apparatus using Any-maze software. The expression of glial fibrillary acidic protein (GFAP) and S100B in hippocampus
and cerebrospinal fluid were measured using ELISA assay, and hippocampal GFAP immunoreactivity was evaluated by means of immunohistochemistry
and optical densitometry. The results showed that physical exercise prevents and/or reverts spatial memory impairments observed
in NTD animals (P < 0.01). Decreased locomotor activity was observed in both the NTD and TD groups when compared with controls (P < 0.05). ELISA and immunohistochemistry analyzes showed there was a reduction in GFAP levels in the hippocampus of NTD animals,
which was not found in TD group. ELISA also showed an increase in S100B levels in the cerebrospinal fluid from the NTD group
(P < 0.01) and no such increase was found in the TD group. Our findings indicate that physical exercise prevents and/or reverts
the cognitive deficits and astroglial alterations induced by T1DM. 相似文献
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José María Ortiz-Salvador Daniela Subiabre-Ferrer Ana García Rabasco Altea Esteve-Martínez Violeta Zaragoza-Ninet Víctor Alegre de Miquel 《Anales de pediatría (Barcelona, Spain : 2003)》2018,88(6):309-314
Introduction
Hand eczema is a frequent disease in adults. Diagnosing the cause of hand eczema is difficult due to different classifications. There is lack of evidence on hand eczema and its causes in children.Material and method
A total of 389 children between 0 and 16 years were identified between 1996 and 2016, from whom 42 (10.8%) with exclusively hand eczema were selected. In all cases a standard battery of epicutaneous patch tests was performed, as well as additional batteries depending on the clinical suspicion. The clinical and epidemiological features of these children were recorded and compared against children with eczema in other locations.Results
The 42 children with hand eczema included 25 (60.5%) girls, and 17 (40.5%) boys, with a mean age of 10.6 +- 3.9 years, and did not differ from that of children with eczema in other locations. The definitive diagnosis after patch-testing was Atopic Dermatitis in 15 cases, Allergic Contact Dermatitis in 14 patients, Endogenous Vesiculous Eczema in 6 cases, Endogenous Hyperkeratotic Eczema in 5 cases, and Irritant Contact Dermatitis in 2 cases. The most frequent allergens detected were thiomersal (9 cases), nickel (5 cases), mercury (5 cases), and cobalt (4 cases).Conclusion
Hand eczema is a common condition in children. The most common cause is atopic dermatitis, although cases of allergic contact dermatitis manifesting as hand eczema are not uncommon. Any child with eczema of hands in whom an allergic cause is suspected should be referred for patch- testing. 相似文献100.