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From 1985-1987, a total of 34 couples undergoing superovulation for a
single in-vitro fertilization (IVF) cycle with clomiphene citrate and
purified follicle stimulating hormone (FSH) or human menopausal
gonadotrophin (HMG) were randomly allocated doses of intra-nasal buserelin
to induce an endogenous gonadotrophin surge, prior to oocyte collection.
The doses ranged from a single 25 microg dose to 100 microg every 4 h for
20 h. In three cycles the treatment was abandoned because of a poor ovarian
response. In the remaining 31 cycles buserelin was given to induce the
endogenous gonadotrophin surge, but there was evidence of premature
luteinization in eight cycles and a premature gonadotrophin surge in four
cycles. Although a single dose as low as 40 microg induced a surge and
resulted in a pregnancy, a single dose of 50 microg proved the most
effective minimal dose consistently to induce a gonadotrophin surge and
oocyte maturation. Recent reports using gonadotrophin-releasing hormone
(GnRH) analogues to induce a gonadotrophin surge has prompted publication
of this previously unpublished data.
相似文献
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Endoscopic retrograde biliary drainage 总被引:1,自引:0,他引:1
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Kim WM; Merskey C; Deming QB; Adel HN; Wolinsky H; Clarkson TB; Lofland HB 《Blood》1976,47(2):275-286
Inbred Carworth Farms Nelson (CFN) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, II, V, VII, VIII, and X than did controls. Conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors II, V, VII, X and XII and of blood platelets than did controls. A loop-shaped polyethylene cannula was inserted into the aorta to assess the potential for thrombosis. The hyperlipidemic group obstructed this significantly faster and the hypolipidemic group slower than did the controls. Normal CFN rats made hypertensive by unilateral renal artery clip developed hypertension together with significantly elevated serum cholesterol and factor VII and X levels. Rhesus monkeys with diet-induced hyperlipidemia showed shorter prothrombin times and higher factor X levels than did controls on normal diet. By selective breeding, two groups of squirrel monkeys were obtained. Both groups had similar serum cholesterol levels on a normal diet but one group (hyperresponders) showed higher serum cholesterol levels on a cholesterol-containing diet than did the other (hyporesponder) group. Both groups showed significantly elevated levels of factors II, V, VII, IX and X on a cholesterol-containing diet. There was good correlation between the levels of many coagulation factors and serum cholesterol in both rats and monkeys. If thrombosis is important in the genesis of atherosclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease. 相似文献
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