全文获取类型
收费全文 | 627篇 |
免费 | 27篇 |
国内免费 | 14篇 |
专业分类
儿科学 | 48篇 |
妇产科学 | 4篇 |
基础医学 | 60篇 |
口腔科学 | 17篇 |
临床医学 | 107篇 |
内科学 | 94篇 |
皮肤病学 | 8篇 |
神经病学 | 14篇 |
特种医学 | 191篇 |
外科学 | 31篇 |
综合类 | 33篇 |
预防医学 | 6篇 |
眼科学 | 2篇 |
药学 | 43篇 |
肿瘤学 | 10篇 |
出版年
2020年 | 2篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 5篇 |
2014年 | 15篇 |
2013年 | 12篇 |
2012年 | 3篇 |
2011年 | 8篇 |
2010年 | 13篇 |
2009年 | 18篇 |
2008年 | 4篇 |
2007年 | 16篇 |
2006年 | 8篇 |
2005年 | 12篇 |
2004年 | 5篇 |
2003年 | 11篇 |
2002年 | 4篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 20篇 |
1998年 | 39篇 |
1997年 | 47篇 |
1996年 | 38篇 |
1995年 | 39篇 |
1994年 | 23篇 |
1993年 | 26篇 |
1992年 | 14篇 |
1991年 | 19篇 |
1990年 | 16篇 |
1989年 | 13篇 |
1988年 | 23篇 |
1987年 | 23篇 |
1986年 | 20篇 |
1985年 | 18篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 22篇 |
1979年 | 4篇 |
1978年 | 12篇 |
1977年 | 22篇 |
1976年 | 12篇 |
1975年 | 8篇 |
1974年 | 1篇 |
1963年 | 2篇 |
1943年 | 1篇 |
排序方式: 共有668条查询结果,搜索用时 11 毫秒
661.
JKS PARIHAR RG DASH DP VATS SC VERMA PK SHOO FEA RODRIGUES AP KAMATH 《Medical Journal Armed Forces India》2001,57(3):207-209
30 cases of open angle glaucoma with cataract who underwent phacoemulsification, PMMA phaco profile IOL implantation and trabeculectomy through same incision were critically evaluated. The mean controlled, preoperative intra ocular pressure was 20 mm of Hg (range 18 to 35 mm of Hg) by aplanation method. Mean post operative pressure after 12 months was 13 mm of Hg (range 11 to 22 mm of Hg) intra operative hyphaema, post operative uveitis were noted problems. Periodic, post operative optic disc and field evaluation remained static in 66% cases. Visual acuity of 6/12 or better was achieved in 60% cases. Failure to restore glaucoma control without medication was seen in 13.3% cases after 9–12 months. The combined phacotrabeculectomy is an effective single step technique of managing concurrent glaucoma with cataract.Key words: Single incision, Phacotrabeculectomy 相似文献
662.
663.
664.
Background
Cross-sectional study was carried out to determine the frequency of subtelomeric abnormalities in children with idiopathic mental retardation (MR).Method
Multiplex ligation-dependant probe amplification technique was used to detect subtelomeric abnormalities.Results
Out of 35 children, 21 (60%) were males. Family history of MR was present in 23%. Main clinical features included speech delay in all motor delay cases (83%) and non-specific dysmorphic features (77%).Conclusion
Associated clinical features were more in children with intelligence quotient (IQ) < 50 (P < 0.05). Subtelomeric deletion (4q35) was observed in one child. 相似文献665.
ESG Stroes JJP Kastelein A Bénardeau O Kuhlmann D Blum LA Campos RG Clerc EJ Niesor 《British journal of pharmacology》2009,158(7):1763-1770
Background and purpose:
The association between torcetrapib and its off-target effects on blood pressure suggested a possible class-specific effect. The effects of dalcetrapib (RO4607381/JTT-705) and torcetrapib on haemodynamics and the renin-angiotensin-aldosterone system (RAAS) were therefore assessed in a rat model.Experimental approach:
Arterial pressure (AP) and heart rate were measured by telemetry in normotensive and spontaneously hypertensive rats (SHR) receiving torcetrapib 10, 40 or 80 mg·kg−1·day−1; dalcetrapib 100, 300 or 500 mg−1·kg·day−1; or vehicle (placebo) for 5 days. Expression of RAAS genes in adrenal gland, kidney, aorta and lung from normotensive rats following 5 days'' treatment with torcetrapib 40 mg·kg−1·day−1, dalcetrapib 500 mg·kg−1·day−1 or vehicle was measured by quantitative polymerase chain reaction.Key results:
Torcetrapib transiently increased mean AP in normotensive rats (+3.7 ± 0.1 mmHg), whereas treatment in SHR resulted in a dose-dependent and sustained increase [+6.5 ± 0.6 mmHg with 40 mg·kg−1·day−1 at day 1 (P < 0.05 versus placebo)], which lasted over the treatment period. No changes in AP or heart rate were observed with dalcetrapib. Torcetrapib, but not dalcetrapib, increased RAAS-related mRNAs in adrenal glands and aortas.Conclusions and implications:
In contrast to torcetrapib, dalcetrapib did not increase blood pressure or RAAS-related gene expression in rats, suggesting that the off-target effects of torcetrapib are not a common feature of all compounds acting on cholesteryl ester transfer protein. 相似文献666.
WOLFRAM GRIMM M.D. JULIA SHARKOVA M.D. JÖRG HEITMANN M.D. † REAS JERRENTRUP M.D. † ULRICH KOEHLER M.D. † BERNHARD MAISCH M.D. 《Pacing and clinical electrophysiology : PACE》2009,32(S1):S8-S11
Study Objectives: To examine the prevalence and clinical significance of sleep-disordered breathing in patients with implantable cardioverter defibrillators (ICD).
Methods and Results: Overnight sleep studies were performed in 129 ICD recipients who had no history of sleep apnea. The mean left ventricular ejection fraction (LVEF) was 29 ± 11%. Mild, moderate, and severe sleep apnea was diagnosed in the presence of an apnea/hypopnea index (AHI) of 5–15/h, 15.1–30/h, and >30/h, respectively. No sleep apnea was present in 49 patients (38%), 57 (44%) had central sleep apnea (CSA), and 23 patients (18%) had obstructive sleep apnea (OSA). Mild, moderate, and severe sleep apnea were present in 25%, 31%, and 44% of patients with CSA, compared with 52%, 22%, and 26% of patients with OSA (P < 0.05). LVEF was similar in patients with versus without OSA or CSA. Patients with CSA were significantly older and had a higher prevalence of ischemic cardiomyopathy than patients without sleep apnea.
Conclusions: Previously undiagnosed CSA is common in ICD recipients. Severely disordered breathing during sleep was more prevalent among patients with CSA than patients with OSA. This prospective, observational study will examine the long-term clinical significance of sleep-disordered breathing in ICD recipients. 相似文献
Methods and Results: Overnight sleep studies were performed in 129 ICD recipients who had no history of sleep apnea. The mean left ventricular ejection fraction (LVEF) was 29 ± 11%. Mild, moderate, and severe sleep apnea was diagnosed in the presence of an apnea/hypopnea index (AHI) of 5–15/h, 15.1–30/h, and >30/h, respectively. No sleep apnea was present in 49 patients (38%), 57 (44%) had central sleep apnea (CSA), and 23 patients (18%) had obstructive sleep apnea (OSA). Mild, moderate, and severe sleep apnea were present in 25%, 31%, and 44% of patients with CSA, compared with 52%, 22%, and 26% of patients with OSA (P < 0.05). LVEF was similar in patients with versus without OSA or CSA. Patients with CSA were significantly older and had a higher prevalence of ischemic cardiomyopathy than patients without sleep apnea.
Conclusions: Previously undiagnosed CSA is common in ICD recipients. Severely disordered breathing during sleep was more prevalent among patients with CSA than patients with OSA. This prospective, observational study will examine the long-term clinical significance of sleep-disordered breathing in ICD recipients. 相似文献
667.
JÖRG OTTO SCHWAB STEFAN WEBER HEIKO SCHMITT MARY-KAY STEEN-MUELLER MICHAEL COCH HARALD TILLMANNS MARC BECKER CHRISTOPH LENZEN BERND WALDECKER 《Pacing and clinical electrophysiology : PACE》2001,24(6):957-961
Tachycardia induced alternation of the T wave (TWA) has been associated with arrhythmia morbidity in mixed patient populations. However, less is known concerning the general incidence of TWA and its usefulness in risk stratification early after acute myocardial infarction (MI). TWA was prospectively and systematically assessed in 140 consecutive patients 15 +/- 6 days after acute MI and prior to discharge. Results of TWA measurements were compared to other noninvasive risk markers, LV function, and coronary angiography. Sustained TWA was present at rest or inducible during exercise in 27% of patients. The patient-specific heart rate for the onset of TWA was 98 +/- 9 beats/min. After multivariate analysis, TWA correlated with age (P = 0.02) and LV function (P = 0.002) and occurred more often in patients after nonanterior MI (P = 0.03). Acute results of Holter monitoring, late potentials by signal-averaged ECG, and heart rate variability were unrelated to the TWA status. During follow-up (451 +/- 210 days) two major arrhythmic events occurred. The incidence of TWA early after MI is about 25%. TWA is related to age and LV function but not to other common arrhythmia markers. Although TWA does not appear to be related to excessive cardiac morbidity, evaluation of the prognostic significance of TWA requires further study. 相似文献
668.