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991.
Masahiro Yamashita Gaston Picchio Ricardo Veronesi Sadayuki Ohkura Patricia Bare Masanori Hayami 《Journal of medical virology》1998,55(2):152-160
To understand the origin and past dissemination of human T-cell leukemia/lymphotropic virus type I (HTLV-I) in Latin America, we conducted a phylogenetic study of five new HTLV-I isolates from Argentina. We sequenced partial fragments of long terminal repeats (LTR) of the new HTLV-Is, and then the sequences were subjected to a phylogenetic analysis for comparison with other HTLV-Is of various geographical origins. Our results indicated that all the isolates were members of the Cosmopolitan group. Furthermore, most (four out of five isolates) of the new HTLV-Is belonged to the Transcontinental (A) subgroup, the most widespread subgroup of the four subgroups in the Cosmopolitan group. In this subgroup, they were closely related to HTLV-Is found in other South American countries including those of Amerindians, and were different from those found in Africa. In contrast, the remaining one HTLV-I (ARGMF) did not show any clear similarity to known HTLV-I isolates belonging to the Cosmopolitan group. The close similarity of South American HTLV-Is strongly suggests a common origin of the virus in this continent. Our results do not support the proposed idea of recent introduction of HTLV-I into South America as a consequence of the slave trade from Africa, where phylogenetically different HTLV-Is predominate. J. Med. Virol. 55:152–160, 1998. © 1998 Wiley-Liss, Inc. 相似文献
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Alison E.R. Meadows Anne C. Reck Hannah Gaston Anthony G. Tyers 《Orbit (Amsterdam, Netherlands)》2013,32(3):177-181
Involutional entropion is the commonest cause of entropion in the elderly population. Many surgical procedures have been described to correct it. The everting suture technique is simple and quick and can be undertaken in the clinic or even away from a medical setting. However, it has been regarded as a temporary cure, especially in the presence of horizontal lower lid laxity. We reviewed the results of everting sutures in 55 lids of 50 patients. The minimum follow-up was 18 months. 78% of patients had no recurrence of their entropion. Our results suggest that horizontal eyelid laxity may not be the only major factor in recurrent entropion following everting sutures. Dermatochalasis with orbital fat prolapse may also contribute. 相似文献
996.
M. Shahid N. Albergo T. Purvis K. Heron L. Gaston S. Carter R. Grimer L. Jeys 《European journal of surgical oncology》2017,43(1):175-180
We reviewed the oncological and functional outcomes of patients treated for a primary sarcoma possibly involving the knee joint and present an algorithm to guide treatment.The records of 76 patients who had a primary bone or soft tissue sarcoma possibly invading the knee between 1996 and 2012 were identified. Mean age and follow-up was 32 years (9–74) and 64 months (12–195), respectively.Patients were grouped according to the resection (Intra-articular [IAR] vs. Extra-articular [EAR] vs. Amputation/rotationplasty) for survival and functional outcomes.Overall 5 and 10 year survival was 61% and 53%, respectively. No differences in survival were found between the 3 groups (p = 0.55). Sixteen patients developed local recurrence with no difference between the groups. Mean MSTS score was 24.5 (12–30). Mean flexion at final follow-up was 106° (70–130°).We conclude that EAR of the knee allows for good oncologic and functional outcomes but with an increased risk of complications compared to IAR. Intra-operative assessment of joint involvement can be done in patients where joint infiltration by the tumour is not clear to avoid an unnecessary EAR. For chondrosarcoma patients with joint involvement, an EAR should be carefully considered because they present a significantly higher local recurrence risk. 相似文献
997.
Gretchen E. Tietjen MD ; Jan L. Brandes MD ; B. Lee Peterlin DO ; Arnolda Eloff MD ; Rima M. Dafer MD MPH ; Michael R. Stein MD ; Ellen Drexler MD ; Vincent T. Martin MD ; Susan Hutchinson MD ; Sheena K. Aurora MD ; Ana Recober MD ; Nabeel A. Herial MD MPH ; Christine Utley MSN CNP ; Leah White MPH ; Sadik A. Khuder MPH PhD 《Headache》2009,49(9):1333-1344
Background.— Cutaneous allodynia (CA) in migraine is a clinical manifestation of central nervous system sensitization. Several chronic pain syndromes and mood disorders are comorbid with migraine. In this study we examine the relationship of migraine‐associated CA with these comorbid conditions. We also evaluate the association of CA with factors such as demographic profiles, migraine characteristics, and smoking status that may have an influence on the relationships of CA to pain and mood. Methods.— Data are from a cross‐sectional multicenter study of comorbid conditions in persons seeking treatment in headache clinics. Diagnosis of migraine was determined by a physician based on the International Classification of Headache Disorders‐II criteria. Participants completed a self‐administered questionnaire ascertaining sociodemographics, migraine‐associated allodynia, physician‐diagnosed comorbid medical and psychiatric disorders, headache‐related disability, current depression, and anxiety. Results.— A total of 1413 migraineurs (mean age = 42 years, 89% women) from 11 different headache treatment centers completed a survey on the prevalence of comorbid conditions. Aura was reported by 38% and chronic headache by 35% of the participants. Sixty percent of the study population reported at least one migraine‐related allodynic symptom, 10% reported ≥4 symptoms. Symptoms of CA were associated with female gender, body mass index, current smoking, presence of aura, chronic headaches, transformed headaches, severe headache‐related disability, and duration of migraine illness from onset. The prevalence of self‐reported physician diagnosis of comorbid pain conditions (irritable bowel syndrome, chronic fatigue syndrome, fibromyalgia) and psychiatric conditions (current depression and anxiety) was also associated with symptoms of CA. Adjusted ordinal regression indicated a significant association between number of pain conditions and severity of CA (based on symptom count). Adjusting for sociodemographics, migraine characteristics, and current depression and anxiety, the likelihood of reporting symptoms of severe allodynia was much higher in those with 3 or more pain conditions (odds ratio = 3.03, 95% confidence interval: 1.78‐5.17), and 2 pain conditions (odds ratio = 2.67, 95% confidence interval: 1.78‐4.01) when compared with those with no comorbid pain condition. Conclusion.— Symptoms of CA in migraine were associated with current anxiety, depression, and several chronic pain conditions. A graded relationship was observed between number of allodynic symptoms and the number of pain conditions, even after adjusting for confounding factors. This study also presents the novel association of CA symptoms with younger age of migraine onset, and with cigarette smoking, in addition to confirming several previously reported findings. 相似文献
998.
Elena Guillen Gaston J. Pineiro Ignacio Revuelta Diana Rodriguez Marta Bodro Asuncin Moreno Josep M. Campistol Fritz Diekmann Pedro Ventura‐Aguiar 《American journal of transplantation》2020,20(7):1875-1878
COVID‐19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Immunocompromised patients often present atypical presentations of viral diseases. Herein we report a case of a COVID‐19 infection in a solid organ transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48 hours. In these high risk populations, protocols for screening for SARS‐Cov2 may be needed to be re‐evaluated. 相似文献
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