Modern Health Journalism and the Impact of Social Media

Scholarly journals are hubs of hypotheses, evidence-based data, and practice recommendations that shape health research and practice worldwide. The advancement of science and information technologies has made online accessibility a basic requirement, paving the way for the advent of open access publishing, and more recently, to web-based health journalism. Especially in the time of the current pandemic, health professionals have turned to the internet, and primarily to social media, as a source of rapid information transfer and international communication. Hence, the current pandemic has ushered an era of digital transformation of science, and we attempt to understand and assess the impact of this digitization on modern health journalism.     

Intermediate and high peri-operative cardiac enzyme release following isolated coronary artery bypass surgery are independently associated with higher one-year mortality

Background  

The relationship between cardiac enzyme (CE) release following coronary artery bypass surgery (CABG) and medium term outcome is unclear. We sought to determine the relationship between post-operative CE release and one-year survival following isolated CABG.     

钙结合蛋白D28k在小鼠肾脏发育中的表达

目的:观察钙结合蛋白D28k在小鼠肾脏发育中表达规律及定位,探讨钙结合蛋白D28k在小鼠肾脏发育中的作用。方法:实验于2006-03/09在辽宁医学院组织胚胎学实验室完成。选取25～30g健康成年昆明小白鼠,采用检查阴道栓脱落的方法确定其受孕后,选取胚龄10,12,14,16,18d的胎鼠和生后日龄1,3,7,14,21,40d的仔鼠,每组取8只鼠。将各胚(日)龄小鼠剖腹取出肾脏,应用免疫荧光技术对各组小鼠肾脏钙结合蛋白D28k表达进行定性观察;应用蛋白印迹技术(Western blotting)对不同发育阶段的小鼠远端肾单位钙结合蛋白D28k的表达进行定量的测定。结果:①免疫荧光结果:钙结合蛋白D28k在胚龄10d胎鼠肾脏未见表达,胚龄12d在输尿管芽微量表达,胚龄14d在输尿管芽Y型分支表达,表达量增加,胚龄16d在输尿管芽壶腹表达强烈,且在肾单位与输尿管芽壶腹连接部有少量表达。胚龄18d到生后7d,钙结合蛋白D28k表达量逐渐增加,并定位于远曲小管、连接小管、皮质集合管。生后7d到生后40d,钙结合蛋白D28k在远曲小管、连接小管、皮质集合管表达丰富,在髓质集合管表达下降。钙结合蛋白D28k表达部位在输尿管芽或远曲小管、连接小管、皮质集合管上皮细胞胞浆内。②Western blotting检测结果:胚龄12d钙结合蛋白D28k表达量极低,无法检测。胚龄14d到胚龄16d,钙结合蛋白D28k表达量增加[(12.0994±0.6911),(13.2383±0.1729),P<0.01]。胚龄16d与胚龄18d钙结合蛋白D28k表达量无显著性差异。胚龄18d到生后7d钙结合蛋白D28k表达量明显增加[(13.8447±0.2385),(15.2718±0.2019),(16.3208±0.2839),(19.3383±0.4044),P<0.01]。生后7d到生后14d,钙结合蛋白D28k表达量减弱,差异有显著性意义[(19.3383±0.4044),(15.8915±1.0185),P<0.01]。生后14d到生后40d钙结合蛋白D28k表达量差异无显著性。结论:在小鼠肾脏发育中,钙结合蛋白D28k在胚龄12d胎鼠肾脏输尿管芽微弱表达,随胚(日)龄增加其表达逐渐增加,生后7d达最大水平,并定位于远曲小管、连接小管和皮质集合管。此后表达减弱并趋于平稳。钙结合蛋白D28k表达部位在输尿管芽或远曲小管、连接小管、皮质集合管上皮细胞胞浆内。     

Lack of association between leptin G2548A gene polymorphism and Behçet''s disease

Background Behçet's disease is a chronic, multisystem, inflammatory disease characterized by the predominance of T‐helper 1 cytokines. The disease is also characterized by infiltration of lymphocytes and neutrophils into the affected tissues. Because cytokines are involved in the regulation of lymphocyte and phagocyte functions, they may play an important role in the pathogenesis of Behçet's disease. Leptin, a member of the gp 130 family of cytokines, induces a strong T‐helper 1 response and is regarded as a proinflammatory inducer. Recent studies have shown that serum leptin concentration was increased in patients with Behçet's disease and correlated with disease activity. Objectives We aimed to investigate the role of G2548A polymorphism of leptin gene in patients with Behçet's disease and compare the results with healthy controls. Patients and methods A total of 93 subjects with Behçet's disease and 125 healthy controls were included in this study. Analyses of G‐2548A polymorphism of the LEP gene were performed using the PCR‐restriction fragment length polymorphism technique. The genotypes (GG, GA, and AA of leptin G2548A) and alleles (G and A of leptin 2548) were scored and the frequency was estimated. The frequencies of the alleles and genotypes in patients and controls were compared. We analysed the correlation between leptin gene polymorphism and the clinical features of BD. Results Both genotype and allele frequencies were not significantly different between controls and Behçet's disease patients [OR = 0.67, 95% CI (0.35–1.29), P = 0.197 and OR = 0.77, 95% CI (0.52–1.15), P = 0.184]. We did not find any significant relationship between leptin gene polymorphism and the clinical features of BD (P > 0.05). Conclusion In the present case‐control study, we found no evidence of an association between the G‐2548A variant of the leptin gene and BD among Turks. Further studies are needed to investigate serum leptin level to explain the mechanisms behind the lack of association between leptin G2548A gene polymorphism and BD.     

Inappropriate Sinus Tachycardia Following Radiofrequency Ablation of AV Nodal Tachycardia: Incidence and Clinical Significance

The incidence and consequences of inappropriate sinus tachycardia following modification of the AV nodal area with radiofrequency energy were prospectively studied in a consecutive series of 118 patients. Twelve (10%) patients developed this complication, which persisted less than 1 week in all but three patients. Inappropriate sinus tachycardia was only observed after fast pathway ablation. Only four patients required temporary treatment with a beta blocker.     

静脉留置针输液中静脉炎7例的处理

0　引言　封闭式静脉留置套管针进行静脉输液的广泛应用,对改善患者生活质量,提高医护人员工作效率发挥了重要作用.我科1998年开始普及使用,但同时存在一些不足之处,在长期使用中,我们发现一些患者出现了局部渗漏、红、肿、痛等情况,现就96例套管针使用者,7例患者不同程度地出现静脉炎后的护理观察、处理体会报告如下.1　临床资料　本组96(男40,女56)例患者,年龄1～67岁,应用套管针时间1～5d,7例不同程度出现局部红、肿、热、痛现象.1例应用可达龙24h内出现机械性静脉炎,2例48h出现化学性静脉炎,2例同时应用多巴胺、多巴酚丁胺3～6μg.收稿…     

Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms

Platelets play a crucial role in thrombosis, inflammation, immunity and atherogenesis. Antiplatelet agents are widely used in patients with acute coronary syndrome and other cardiovascular disorders. Aspirin and clopidogrel are the most commonly prescribed antiplatelet agents, with a relatively safe profile and efficiency in a variety of clinical conditions. Numerous prospective studies have revealed variability of antiplatelet efficacy. The so called "antiplatelet resistance" prompted a search for mechanisms implicated in poor responsiveness to aspirin and clopidogrel therapy. In this regard, genetic polymorphisms in the platelet receptor genes attracted considerable interest. Specific genetic variants in platelet receptors such as the P2Y12, glycoprotein (GP) IIb/IIIa, GPIa/IIa, GPIb/IX/V and the cytochrome P450 (CYP) family of genes are associated with variable response to antiplatelet therapy and cardiovascular events. Genetic polymorphisms and haplotypes that comprehensively capture the genetic information encoded within the platelet receptor genes can, to some extent, predict response to the antiplatelet drug better than any single genotype. Genotyping for multiple receptor variants in patients on antiplatelet therapy, complemented by standardized quantification of platelet function, can provide useful information for future drug design studies and possibly for personalized antiplatelet therapy and prevention of thrombotic events. Additional information is, however, needed to evaluate the cost-effectiveness of complex genetic and platelet function testing.     

Cation-osmotic Haemolysis in Patients with Retinal Vein Occlusion

The purpose of this work was to use a new technique to assess erythrocyte deformability in patients with retinal vein occlusion. Erythrocyte microrheology changes were measured by cation-osmotic haemolysis (COH) in healthy donors and in patients with both central (n= 6) and branch (n= 16) retinal vein occlusion up to 12 months after the occlusion. The patient group consisted of five patients with ischaemic and 17 with oedematous vein occlusion. The control group consisted of the same number of age-, sex- and risk factor (hypertension)-matched donors. In patients with retinal vein occlusion, COH was significantly decreased compared to the control group. The decrease was most marked at low and high concentrations of incubating media where the differences reached high statistical significance (p<0.01–0.001). In our previous experiments we showed that COH and erythrocyte deformability (ED) are closely related and that COH reflects basic information about erythrocyte deformability. Thus, decreased COH in patients with retinal vein occlusion points to reduced ED in comparison with the control group. We, therefore, assume that impairment in ED together with other microrheological abnormalities contributes to the pathophysiology of changes in patients with retinal vein occlusion.