全文获取类型
收费全文 | 78篇 |
免费 | 5篇 |
专业分类
儿科学 | 5篇 |
基础医学 | 12篇 |
内科学 | 7篇 |
神经病学 | 9篇 |
特种医学 | 1篇 |
外科学 | 20篇 |
预防医学 | 1篇 |
药学 | 2篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 1篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 3篇 |
2016年 | 2篇 |
2015年 | 5篇 |
2013年 | 2篇 |
2012年 | 6篇 |
2011年 | 6篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 5篇 |
2007年 | 5篇 |
2006年 | 6篇 |
2005年 | 1篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1996年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
排序方式: 共有83条查询结果,搜索用时 31 毫秒
71.
Loss of FHIT expression in transitional cell carcinoma of the urinary bladder 总被引:14,自引:0,他引:14
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
72.
73.
Alba A. Brandes A. Tosoni E. Franceschi V. Blatt A. Santoro M. Faedi P. Amistà M. Gardiman R. Labianca C. Bianchini M. Ermani M. Reni 《Cancer chemotherapy and pharmacology》2009,64(4):769-775
Background Standardized salvage treatment has not yet proved effective in glioblastoma multiforme (GBM) patients who receive prior standard
radiotherapy plus concomitant and adjuvant temozolomide.
Methods Patients with progressive GBM after radiotherapy plus concomitant and/or adjuvant temozolomide received three-weekly doses
(100–75 mg m2) of fotemustine followed, after a 5-week rest, by fotemustine (100 mg m2) every 3 weeks for ≤1 year.
Results Forty-three patients (29 M, 14 F; median age 51 years, range 34–68; median KPS 90) were enrolled. Progression-free survival
at 6 months (PFS-6) was 20.9% (95% CI: 9–33%); three patients (7.1%) had partial response (PR); 15 (34.9%), disease stabilization
(SD). The median survival was 6 months (95% CI: 5–7). MGMT promoter status was methylated in 8 (18.6%) and unmethylated in 26 (60.5%) and not assessable in 9 (20.9%) patients, respectively.
Disease control was 75% versus 34.6% in methylated and unmethylated MGMT patients (P = 0.044); no significant difference was found between groups for PFS-6 and survival. Grade 3 and 4 thrombocytopenia and neutropenia
were observed in 20.9 and 16.3% of patients, during the induction phase, and in 0 and 9.5% patients during the maintenance
phase, respectively.
Conclusions The findings of the present trial, that evaluate fotemustine in a homogeneous population, may represent a new benchmark for
nitrosourea activity. Moreover, this is the first study to evaluate correlation between MGMT promoter status and outcome of fotemustine for relapsing GBM previously treated with radiotherapy and temozolomide. 相似文献
74.
Ficarra V Zattoni F Cunico SC Galetti TP Luciani L Fandella A Guazzieri S Maruzzi D Sava T Siracusano S Pilloni S Tasca A Martignoni G Gardiman M Tardanico R Zambolin T Cisternino A Artibani W;Gruppo Uro-Oncologico del Nord Est 《Cancer》2005,103(12):2507-2516
BACKGROUND: The objective of the current study was to identify independent clinical and pathologic variables that were predictive of lymph node involvement in patients with squamous cell carcinoma of the penis in a multicenter series with the intent to select patients who were suitable to undergo immediate inguinal lymphadenectomy. METHODS: Data were analyzed from 175 patients who underwent surgery for penile carcinoma in 11 urologic centers participating in the Gruppo Uro-Oncologico del Nord-Est (Northeast Uro-Oncological Group) Penile Cancer Data Base. Pathologically positive lymph nodes were defined as the presence of histologically confirmed lymph node metastasis in patients who underwent either immediate or delayed inguinal and/or pelvic lymphadenectomy. Patients who had clinically positive lymph nodes with cytologically positive fine-needle aspiration results and who had not undergone lymphadenectomy were censored. RESULTS: Overall, lymph-node involvement was observed in 71 of 175 patients (40.6%) included in the analyses. After analyzing the whole group of patients, the following variables were identified as independent predictors of pathologic lymph node metastasis: clinical lymph node status, pathologic stage of the primary tumor, venous and lymphatic embolizations, and histologic grade. In the subgroup of patients with clinically negative lymph nodes, tumor thickness, histologic grade, lymphatic and venous embolizations, infiltration of both corpus spongiosum and urethra, and pathologic stage of the primary tumor (according to the 1997 TNM classification system) were predictive of lymph node involvement on univariate analysis. The generated logistic regression model showed that venous and/or lymphatic embolizations and infiltration of the corpus spongiosum and/or urethra were independent predictors of pathologic lymph node metastasis in patients with clinically negative lymph nodes. CONCLUSIONS: Venous and/or lymphatic embolizations played relevant roles as predictors of pathologic lymph node involvement in patients with penile neoplasia and should be considered important parameters in determining which patients with clinically negative lymph nodes should undergo immediate lymphadenectomy. 相似文献
75.
76.
Alessandra Drusco Arianna Bottoni Alessandro Laganà Mario Acunzo Matteo Fassan Luciano Cascione Anna Antenucci Prasanthi Kumchala Caterina Vicentini Marina P. Gardiman Hansjuerg Alder Mariantonia A. Carosi Mario Ammirati Stefano Gherardi Marilena Luscrì Carmine Carapella Nicola Zanesi Carlo M. Croce 《Oncotarget》2015,6(25):20829-20839
Central Nervous System malignancies often require stereotactic biopsy or biopsy for differential diagnosis, and for tumor staging and grading. Furthermore, stereotactic biopsy can be non-diagnostic or underestimate grading. Hence, there is a compelling need of new diagnostic biomarkers to avoid such invasive procedures. Several biological markers have been proposed, but they can only identify specific prognostic subtype of Central Nervous System tumors, and none of them has found a standardized clinical application.The aim of the study was to identify a Cerebro-Spinal Fluid microRNA signature that could differentiate among Central Nervous System malignancies.CSF total RNA of 34 neoplastic and of 14 non-diseased patients was processed by NanoString. Comparison among groups (Normal, Benign, Glioblastoma, Medulloblastoma, Metastasis and Lymphoma) lead to the identification of a microRNA profile that was further confirmed by RT-PCR and in situ hybridization.Hsa-miR-451, -711, 935, -223 and -125b were significantly differentially expressed among the above mentioned groups, allowing us to draw an hypothetical diagnostic chart for Central Nervous System malignancies.This is the first study to employ the NanoString technique for Cerebro-Spinal Fluid microRNA profiling. In this article, we demonstrated that Cerebro-Spinal Fluid microRNA profiling mirrors Central Nervous System physiologic or pathologic conditions. Although more cases need to be tested, we identified a diagnostic Cerebro-Spinal Fluid microRNA signature with good perspectives for future diagnostic clinical applications. 相似文献
77.
L Alessandrini M Fassan MP Gardiman A Guttilla F Zattoni TP Galletti F Zattoni 《Virchows Archiv : an international journal of pathology》2012,461(3):345-350
Thyroid-like follicular carcinoma of the kidney (TLFC) is an unusual histological variant of renal cell carcinoma not included in the current WHO classification of renal tumors. Its morphological features resemble a large spectrum of benign and malignant renal and extra-renal conditions which should be ruled out in the diagnostic process. Because TLFC outcome is different from the other variants of renal cell carcinoma, the exploration for disease-specific markers is mandatory. The aim of the present paper is to illustrate the histological characteristics and immunohistochemical profile of two new cases along with a brief review of the literature. 相似文献
78.
Della Puppa A Rossetto M Berti F Zustovich F Manara R Gardiman MP Scienza R 《Journal of neurosurgical sciences》2010,54(4):159-162
Metastasis of the inner auditory canal is a really rare event. Clinically, it usually presents with rapid worsening cranial nerve palsy. Authors present a review of the literature reporting clinical features, radiological findings, intraoperative aspects of an illustrative case. A 56-year-old female patient presented with a peripheral facial nerve palsy. MRI showed two left p-fossa tumors whose one into the inner canal. Rapid worsening of facial damage despite corticosteroid treatment and the possibility to remove both tumors in the same surgical step suggested authors to operated on the patient. Intraoperatively, inner canal tumor looked totally involving the VII-VIII nerve complex so surgical extirpation was only partially feasible. Posterior wall drilling of the meatus was performed which improved facial palsy. Leptomeningeal spinal seeding occurred and spinal irradiation was performed. The case highlights the importance of maintaining a high degree of awareness of the auditory canal metastasis in patients with a previous history of malignancy who develop a rapid progressive peripheral VII nerve palsy. Furthermore, our case and literature data suggest that inner canal metastasis is a distinct entity from temporal bone and ponto-cerebellar angle metastasis on the base of the peculiarity of clinical features, prognosis, therapeutic strategies. In fact, inner canal metastases usually arise in patients apparently cured, and they imply a better prognosis even if with an higher risk of leptomeningeal seeding. Moreover, surgery rarely allows the removal of the lesion, also if symptoms relief may be achieved, as in our case. 相似文献
79.
Alessandro Della Puppa Marta Rossetto Pietro Ciccarino Giulia Del Moro Antonino Rotilio Renzo Manara Marina Paola Gardiman Luca Denaro Domenico d’Avella Renato Scienza 《Acta neurochirurgica》2010,152(11):1923-1931
Purpose
Carmustine (1,3-bis[2-chloroetyl]-1-nitrosurea (BCNU)) wafers are approved for the local treatment of newly diagnosed and recurrent malignant glioma. Reassuring data on both safety and efficacy of treatment have been previously reported by phase III studies. Although most of related adverse events are reported in the first few months after surgery, there is a lack in the literature of radiological data regarding this period. Few anecdotal experiences have been reported about surgical bed cyst occurrence. The aim of our study is to analyse the radiological course of patients treated with wafers implantation focusing on the relationship between radiological data, and in particular bed cyst occurrence, and safety data. 相似文献80.
Canesso A Gardiman M Salmaso R Alaggio R Ninfo V 《Virchows Archiv : an international journal of pathology》2006,449(2):248-252
Pilocytic astrocytoma is a central nervous system neoplasia that arises during pediatric age. Only few cases have been documented in patients older than 50 years old. It is a low-grade lesion that can rarely undergo malignant changes presenting the histologic features of a high-grade glioma. We report a case of a pilocytic astrocytoma arising in the eyeball of a 53-year-old man affected by glaucoma that underwent malignant evolution. 相似文献