全文获取类型
收费全文 | 2117篇 |
免费 | 126篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 106篇 |
妇产科学 | 64篇 |
基础医学 | 234篇 |
口腔科学 | 29篇 |
临床医学 | 162篇 |
内科学 | 414篇 |
皮肤病学 | 33篇 |
神经病学 | 97篇 |
特种医学 | 65篇 |
外科学 | 397篇 |
综合类 | 45篇 |
预防医学 | 73篇 |
眼科学 | 155篇 |
药学 | 187篇 |
中国医学 | 18篇 |
肿瘤学 | 169篇 |
出版年
2023年 | 11篇 |
2022年 | 33篇 |
2021年 | 81篇 |
2020年 | 49篇 |
2019年 | 65篇 |
2018年 | 93篇 |
2017年 | 52篇 |
2016年 | 78篇 |
2015年 | 71篇 |
2014年 | 105篇 |
2013年 | 134篇 |
2012年 | 160篇 |
2011年 | 192篇 |
2010年 | 91篇 |
2009年 | 102篇 |
2008年 | 149篇 |
2007年 | 153篇 |
2006年 | 133篇 |
2005年 | 121篇 |
2004年 | 101篇 |
2003年 | 81篇 |
2002年 | 52篇 |
2001年 | 22篇 |
2000年 | 10篇 |
1999年 | 18篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 10篇 |
1995年 | 3篇 |
1994年 | 11篇 |
1993年 | 3篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1972年 | 1篇 |
1960年 | 1篇 |
1934年 | 1篇 |
1928年 | 1篇 |
1909年 | 1篇 |
排序方式: 共有2252条查询结果,搜索用时 15 毫秒
101.
Mazer R. Ally Ganesh R. Veerappan Corinne L. Maydonovitch Timothy J. Duncan Joseph L. Perry Eric M. Osgard Roy K. H. Wong 《Digestive diseases and sciences》2009,54(12):2617-2622
Background
Fundic gland polyps (FGP) have been implicated with long-term proton pump inhibitor (PPI) use. 相似文献102.
103.
104.
Naduthottam Palaniswami Kamalesh Kurumboor Prakash Kaniyarakal Pramil Prakash Zacharias Ganesh Narayanan Ramesh Mathew Philip 《Indian journal of gastroenterology》2012,31(6):337-339
The prevalence of diverticular disease of colon of colon is reportedly low in Asian compared to Western countries. We analyzed the prevalence of colonic diverticulosis in a selected cohort of patients undergoing colonoscopy. Retrospective study of records of patients undergoing colonoscopy in a tertiary hospital in southern India. 相似文献
105.
F. T. M. Peters S. Ganesh E. J. Kuipers W. J. Sluiter A. Karrenbeld A. De Jager-Krikken E. C. Klinkenberg-Knol C. B. H. W. Lamers J. H. Kleibeuker 《Scandinavian journal of gastroenterology》2013,48(12):1238-1244
Background: Barrett esophagus (BE) is a premalignant condition resulting from chronic acid gastroesophageal reflux and is associated with increased epithelial cell proliferation. Elimination of acid reflux might decrease cancer risk by affecting cell proliferation in BE. The effect of elimination of acid reflux on epithelial cell proliferation in BE was studied. Methods: Forty-five patients with long segment Barrett esophagus were treated in a randomized 2-year follow-up study with either omeprazole 40 mg b.i.d. (OME) or ranitidine 150 mg b.i.d. (RAN) and were compared for the effect on epithelial cell proliferation. Biopsies were taken 3 cm above the GE junction and just below the Z-line, at 0, 3, 9, and 24 months. Epithelial cell proliferation was determined by in vitro labeling with 5-bromo-2-deoxyuridine and immunohistochemistry. Labeling indices (LI) were established for luminal and crypt epithelium separately. Ambulatory 24-h esophageal pH-metry was performed at 0 and 3 months. Comparisons were made for the timeframes 0-3 months, 3-24 months, and 0-24 months. Results: OME reduced mean acid reflux to 0.1%/24 h, RAN to 9.4%. In the distal and the proximal biopsies, change in LI after 3 months was n.s. at either level for both treatments. In the distal biopsies (OME 22, RAN 23 patients) luminal LI increased significantly for RAN from 3 to 24 months (+ 12.64% month, mean area under the curve (AUC)), while that for OME remained stable, RAN versus OME P < 0.05. Crypt LI increased in both groups, only in RAN significantly so (+ 30.75% month), RAN versus OME n.s. In the proximal biopsies luminal LI at 24 months (OME 20, RAN 21 patients) had increased slightly but not significantly in RAN (+ 8.86% month), RAN versus OME n.s., whereas in the crypts LI in OME it had increased significantly (+ 28.80% month), OME versus RAN n.s. Conclusion: Elimination ofacid reflux resulted in a stabilization of luminal cell proliferative activity of Barrett epithelium in the distal esophagus, whereas this activity increased during continued acid reflux. Whether this finding has any implication for the cancer risk in Barrett esophagus remains to be seen. 相似文献
106.
107.
108.
Ying-Jie Peng Jayasri Nanduri Gayatri Raghuraman Dangjai Souvannakitti Moataz M. Gadalla Ganesh K. Kumar Solomon H. Snyder Nanduri R. Prabhakar 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(23):10719-10724
Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O2 sensing by the carotid body, a sensory organ that monitors arterial blood O2 levels and stimulates breathing in response to hypoxia. We now show that hydrogen sulfide (H2S) is a physiologic gasotransmitter of the carotid body, enhancing its sensory response to hypoxia. Glomus cells, the site of O2 sensing in the carotid body, express cystathionine γ-lyase (CSE), an H2S-generating enzyme, with hypoxia increasing H2S generation in a stimulus-dependent manner. Mice with genetic deletion of CSE display severely impaired carotid body response and ventilatory stimulation to hypoxia, as well as a loss of hypoxia-evoked H2S generation. Pharmacologic inhibition of CSE elicits a similar phenotype in mice and rats. Hypoxia-evoked H2S generation in the carotid body seems to require interaction of CSE with hemeoxygenase-2, which generates carbon monoxide. CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice. 相似文献
109.
We describe an infant who had recurrence of Kawasaki disease and responded to therapy with Intravenous Immune globulin (IVIG)
and highlight the need for recognition of this vasculitis, which is being increasingly recognised in the Indian subcontinent. 相似文献
110.
Nathalie Mainreck Stéphane Brézillon Ganesh D. Sockalingum François-Xavier Maquart Michel Manfait Yanusz Wegrowski 《Journal of pharmaceutical sciences》2011,100(2):441-450
This study describes a complementary infrared (IR) and Raman spectroscopic investigations of a set of biomolecule representatives of glycosaminoglycans (GAGs) class. Both IR and Raman data exhibit characteristic spectral signatures that allow a direct molecular distinction of these compounds. Comparison of these molecular signatures clearly evidences the differences between heparan sulfate and heparin by computing the intensity ratio between the 1248 cm?1 and 1043 cm?1 peaks, corresponding respectively to sulfate and C─O─C linkages. Identically, chondroitin-4-sulfate and chondroitin-6-sulfate are differentiated via the 730 cm?1 and 853 cm?1 bands (axial orientation) and the 822 cm?1 and 1000 cm?1 bands (equatorial orientation). These orientations concern the sulfate groups of these molecules. Secondly, multivariate statistical methods were employed to analyze the data set. Hierarchical cluster analysis (HCA) of both IR and Raman spectra showed a very good differentiation between the different structures. In addition, the sulfatation degree could be obtained from this classification. Principal component analysis using three principal components (PCs) confirmed the findings of HCA and, furthermore, comparisons of the PC loadings highlight the main molecular differences between the members of this class of biological molecules. It is expected that these microspectroscopic methods will be useful in identifying GAG spectral signatures in complex biological systems. 相似文献