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991.
Kaare Lund Hirokazu Kito Mette Blem Skydtsgaard Hiroshi Nakazawa Katsuyo Ohashi-Doi Simon Lawton 《Clinical therapeutics》2019,41(4):742-753
Purpose
Efficient delivery of allergens to the sublingual mucosa is a prerequisite for successful sublingual immunotherapy (SLIT) for allergy, and in order to become available to immune-competent cells embedded in the sublingual mucosa, allergens need to be delivered in a soluble form. Delivery of solubilized allergens poses a particular challenge for tablet-based allergy immunotherapy, in which allergens are administered under the tongue in the form of dry tablets and need to be dissolved rapidly in a small volume of saliva, with little or no agitation. The purposes of this article were to compare the properties of 2 different pharmaceutical SLIT-tablet formulations, freeze-dried and compressed, and to examine how the tablet formulation affects the efficiency with which allergen is delivered from the dry state of the tablet into soluble form.Methods
Two SLIT-tablet formulations, both indicated for grass pollen allergic rhinitis and containing grass pollen extract as the active ingredient, were examined with regard to tablet disintegration times, allergen dissolution kinetics, dependency on solvent volume and agitation, and the achieved recovery of the grass allergen content in soluble form with each tablet.Findings
The freeze-dried and the compressed SLIT-tablet formulations differed markedly with respect to efficiency of allergen release. The freeze-dried tablet disintegrated faster and released grass allergen into solution with a release rate higher than that of the compressed formulation and, in contrast to the compressed formulation, achieved full recovery of the allergen content in soluble form in a small volume of solvent.Implications
Rapid and complete release of soluble allergen in a small volume of solvent, as demonstrated by the freeze-dried formulation, are key elements of efficient sublingual allergen delivery by SLIT-tablets. Complete allergen release means that the full allergen dose of the tablet is recovered from the tablet and made available to the sublingual immune system in soluble form, and rapid release ensures that the immune system becomes exposed to the highest possible dose of soluble allergen for the maximal duration before swallowing. In contrast, a SLIT-tablet formulation that provides incomplete and slower allergen release will likely require a higher allergen content compared to the more efficient formulation, in order to achieve the same dose of soluble allergen, consequently leading to an excess load of allergen that becomes swallowed without having been made immunologically available. 相似文献992.
993.
F Toda H Okuda N Kondo Y Iguchi O Ryoji F Ito K Tanabe N Goya H Nakazawa H Toma 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1999,90(8):745-749
We present a case of spontaneous rupture of renal angiomyolipoma with a tumor thrombus extending from the right renal vein and inferior vena cava to the right atrium. A 41-year-old woman, previously in good health, was referred to our hospital with right flank pain. Computed tomography showed fat densities in both tumor and thrombus. Other imaging examinations also demonstrated a large right renal mass (18 cm in diameter), a long tumor thrombus (13 cm in length) and a small left renal tumor (1.5 cm in diameter). Right nephrectomy and en-bloc removal of the intra caval and intracardiac tumor thrombus were performed on cardiopulmonary bypass. It was pathologically diagnosed as an angiomyolipoma without tuberous sclerosis. At present, three years after surgery the patient is doing well, showing neither metastasis nor increase of the left renal angiomyolipoma. To our knowledge, our case seems to be the 3rd case report of renal angiomyolipoma with a tumor thrombus extending to the right atrium. We conclude that renal angiomyolipoma even with an intra cardiac tumor thrombus can be resected safely and successfully. 相似文献
994.
995.
M Nakamura K Sugita T Inukai K Goi N Miyamoto K Kagami T Okazaki-Koyama T Mori M Saito S Nakazawa 《Leukemia》2001,15(7):1136-1139
996.
997.
A. Townsend Peterson Narayani Barve Luis Mauricio Bini José Alexandre Diniz-Filho Alberto Jiménez-Valverde Andrés Lira-Noriega Jorge Lobo Sean Maher Paulo de Marco Jr. Enrique Martínez-Meyer Yoshinori Nakazawa Jorge Soberón 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(16):E47
998.
Nakazawa Nobuhiro Sohda Makoto Ubukata Yasunari Kuriyama Kengo Kimura Akiharu Kogure Norimichi Hosaka Hisashi Naganuma Atsushi Sekiguchi Masanori Saito Kana Ogata Kyoichi Sano Akihiko Sakai Makoto Ogawa Hiroomi Shirabe Ken Saeki Hiroshi 《Annals of surgical oncology》2022,29(12):7400-7406
Annals of Surgical Oncology - Identification of positive biomarkers for the effects of nivolumab on patients with advanced gastric cancer (AGC) is significant. The Gustave Roussy Immune Score... 相似文献
999.
Kenji Yamao Saburo Nakazawa Masao Fujimoto Hiroyuki Tsuda Kazuyuki Matsumoto Teruhiko Iwase 《Journal of gastrointestinal cancer》1993,14(1):37-44
Summary A total of 44 cases of pancreatic lesions, including hyperplasia (six) cases, adenoma (mucinous cystadenomas [eight] and intraductal
papillary adenoma [eight]), noninvasive intraductal papillary tumors (five), and invasive ductal carcinomas (17) were investigated
possibly to establish a diagnostic marker. We examined the type of mucin secreted and immunoreactivities of antibodies toras-p21 and c-erbB-2 oncogene products. A significant decrease in the amount of mucin was found in invasive lesions, and this was associated
with a shift toward production of neutral mucins and especially sialomucins. Hyperplasia and adenoma, in contrast, demonstrated
a predominance of neutral mucin. The sulfated mucins found in normal epithelium were only very weakly stained in any of the
tumor types. Thirty-three percent of non-invasive intraductal papillary tumors and 88% of invasive ductal adenocarcinomas
demonstrated strong binding of theras-p21 antibody. In contrast no obvious differences in expression of c-erbB-2 were evident between the groups. In conclusion, a combined mucin histochemical/immunohistochemical approach may facilitate
accurate diagnosis. 相似文献
1000.
High diagnostic value of anticalpastatin autoantibodies in rheumatoid arthritis detected by ELISA using human erythrocyte calpastatin as antigen 总被引:3,自引:0,他引:3
Iwaki-Egawa S Matsuno H Yudoh K Nakazawa F Miyazaki K Ochiai A Hirohata S Shimizu M Watanabe Y 《The Journal of rheumatology》2004,31(1):17-22
OBJECTIVE: To develop a quantitative method of measuring autoantibodies against human calpastatin in rheumatoid arthritis (RA) and to determine their diagnostic value compared with other autoimmune and articular diseases. METHODS: We performed a highly sensitive ELISA for IgG and IgM anticalpastatin autoantibodies in human sera using human erythrocyte calpastatin as an antigen. Samples were diluted 1:2000 for the measurement of IgG and 1:400 for IgM. RESULTS: IgG anticalpastatin antibodies were found in the sera of 48 of 58 patients (82.8%) with RA. In contrast, IgG anticalpastatin antibodies were found in the sera of only 2 of 11 (8.3%) patients with osteoarthritis (OA). Compared to sera from patients with other autoimmune diseases, anticalpastatin antibody sensitivity for RA was better than that of systemic lupus erythematosus (5.6%), systemic sclerosis (0%), mixed connective tissue disease (0%), and Sj?gren's syndrome (20%). IgG anticalpastatin antibodies also showed high specificity (96.1%) for RA. Almost 90% of patients with RA were positive for IgG or IgM anticalpastatin antibodies. CONCLUSION: We have developed a simple, sensitive, specific, and quantitative ELISA for anticalpastatin antibodies that may have a high diagnostic value for RA. 相似文献