全文获取类型
收费全文 | 34450篇 |
免费 | 2642篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 344篇 |
儿科学 | 1096篇 |
妇产科学 | 768篇 |
基础医学 | 4465篇 |
口腔科学 | 692篇 |
临床医学 | 3663篇 |
内科学 | 7421篇 |
皮肤病学 | 431篇 |
神经病学 | 2958篇 |
特种医学 | 1231篇 |
外国民族医学 | 2篇 |
外科学 | 4573篇 |
综合类 | 638篇 |
一般理论 | 14篇 |
预防医学 | 3267篇 |
眼科学 | 1080篇 |
药学 | 2129篇 |
中国医学 | 52篇 |
肿瘤学 | 2348篇 |
出版年
2023年 | 231篇 |
2022年 | 385篇 |
2021年 | 877篇 |
2020年 | 479篇 |
2019年 | 765篇 |
2018年 | 884篇 |
2017年 | 641篇 |
2016年 | 646篇 |
2015年 | 771篇 |
2014年 | 1061篇 |
2013年 | 1452篇 |
2012年 | 2202篇 |
2011年 | 2162篇 |
2010年 | 1261篇 |
2009年 | 1105篇 |
2008年 | 1863篇 |
2007年 | 1943篇 |
2006年 | 1775篇 |
2005年 | 1730篇 |
2004年 | 1679篇 |
2003年 | 1486篇 |
2002年 | 1484篇 |
2001年 | 697篇 |
2000年 | 681篇 |
1999年 | 636篇 |
1998年 | 320篇 |
1997年 | 301篇 |
1996年 | 257篇 |
1995年 | 279篇 |
1994年 | 250篇 |
1993年 | 236篇 |
1992年 | 466篇 |
1991年 | 462篇 |
1990年 | 452篇 |
1989年 | 420篇 |
1988年 | 375篇 |
1987年 | 356篇 |
1986年 | 380篇 |
1985年 | 351篇 |
1984年 | 278篇 |
1983年 | 245篇 |
1982年 | 191篇 |
1981年 | 164篇 |
1980年 | 165篇 |
1979年 | 210篇 |
1978年 | 160篇 |
1977年 | 165篇 |
1976年 | 138篇 |
1974年 | 163篇 |
1973年 | 154篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication. 总被引:7,自引:0,他引:7
J H Graziano N J Lolacono T Moulton M E Mitchell V Slavkovich C Zarate 《The Journal of pediatrics》1992,120(1):133-139
We examined the efficacy and safety of meso-2,3-dimercaptosuccinic acid (DMSA) in children with markedly elevated blood lead (BPb) concentrations. Among 19 children with BPb concentrations of 50 to 69 micrograms/dl (2.41 to 3.33 mumol/L) who received a 5-day inpatient oral course of DMSA (1050 mg/m2 per day), the mean BPb concentration decreased by 61%; in four who received calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA) (1000 mg/m2 per day intravenously), it decreased by 45% (p less than 0.0007). Urinary lead excretion was comparable in both groups. Treatment with DMSA was more effective than treatment with CaNa2EDTA in restoring metabolic activity to the heme pathway and was well tolerated even among nine patients who received concomitant iron supplementation and two who had homozygous deficiency of glucose-6-phosphate dehydrogenase. On discharge, these 19 children received either no chelation therapy or DMSA, 350 or 700 mg/m2 per day for 14 days on an outpatient basis. After 14 days the mean BPb values for the no-chelation, low-DMSA, and high-DMSA groups were 73%, 66%, and 50% of the pretreatment values, respectively. We conclude that a 5-day oral course of DMSA is effective in the treatment of children with severe lead poisoning. In addition, on an outpatient basis the administration of DMSA, 700 mg/m2 per day, is capable of delaying the typical rebound in BPb values and should ultimately reduce the need for repeated hospitalizations. 相似文献
42.
Clemens Aigner Peter Jaksch Samy Mazhar Kriztina Czebe Gabriel Marta Sharokh Taghavi Georg Lang Walter Klepetko 《European journal of cardio-thoracic surgery》2004,25(2):184-187
OBJECTIVES: The use of OKT3 for treatment of advanced high-grade acute rejection episodes eventually can result in cytokine release and consecutive pulmonary edema. Temporary extracorporeal membrane oxygenation (ECMO) bridging can be used to overcome this crucial period before the beneficial effects of OKT3 can be observed. METHODS: We summarize our experience with three patients, who underwent lung transplantation and presented with severe acute rejection episodes. OKT3 had to be initiated due to insufficient response to standard rejection therapy with corticosteroids. Upon initiation of OKT3 treatment, a massive life-threatening deterioration of lung function in spite of heavily invasive respirator treatment was seen and temporary ECMO support was imperative to support graft function. Results of this treatment were retrospectively reviewed. RESULTS: In all cases femoro-femoral veno-arterial ECMO was used for support of the impaired graft and after a period of 4-5 days led to a massive improvement of graft function. In the further course two patients could be discharged from hospital and are still alive 30 and 36 months, respectively, after the described incident. One patient died 4 months later due to liver failure. CONCLUSIONS: We conclude that the use of ECMO support in patients experiencing significant side effects from OKT3 therapy is a useful and effective therapeutic tool to overcome the initial critical period until the lung has sufficiently recovered. 相似文献
43.
44.
Although cardiac arrhythmias remain a serious clinical problem in many patients with heart disease, the exact role of antiarrhythmic drug therapy is currently under intense evaluation. Within the last several years it has become clear that there are significant risks as well as potential benefits associated with existing agents. Ongoing studies in large patient populations should help determine the benefit/risk ratio of traditional therapy. Regardless of the outcome of these trials, current electrophysiological dogma will have to be re-evaluated and newer concepts evolve for drug development to make further progress. The goal of this symposium is to exchange information among basic and clinical investigators so as to facilitate the emergence of novel electrophysiological concepts that will form the basis for future generations of antiarrhythmic drugs. 相似文献
45.
Scott W. Powers Kelly C. Byars Monica J. Mitchell Susana R. Patton Teresa Schindler Margaret H. Zeller 《Children's Health Care》2003,32(4):297-311
This pilot study examined a behavioral treatment to increase calorie intake in toddlers with cystic fibrosis. Eight toddlers were randomly assigned to behavioral plus nutrition (BEH) or nutrition intervention (NTR) conditions. Calorie intake and weight were measured at pre- and posttreatment. The BEH group showed a trend for changes in calorie intake pre- to posttreatment (p = .07; 40% increase). Results for the BEH and NTR groups did not differ significantly. Most participants achieved weight gains consistent with normal growth. Seventy-five percent had not shown this pattern during the year prior to intervention. These results support the feasibility and potential for behavioral interventions in this age group. 相似文献
46.
47.
Sylvia Mitchell Veronica A. Bradley John L. Welch Peter G. Britton 《Brain injury : [BI]》1990,4(3):273-279
This study reports on the efficacy of a 'coma arousal procedure'. This procedure involved a programme of vigorous sensory stimulation administered to comatose patients by relatives using Comakits. An experimental group of 12 severely head-injured patients received the coma arousal procedure while a matched control group did not. Total duration of coma and weekly Glasgow Coma Scale Scores were recorded for the two groups. Results indicate that the total duration of coma was significantly shorter and that coma lightened more rapidly for the experimental group. 相似文献
48.
49.
50.
MRI of pancreatic gastrinomas. 总被引:1,自引:0,他引:1
D G Mitchell M Cruvella D J Eschelman M M Miettinen J J Vernick 《Journal of computer assisted tomography》1992,16(4):583-585
Pancreatic islet cell tumors are often small and multiple, and preoperative diagnosis can be difficult. In a woman with hypergastrinemia, angiography and CT each depicted a solitary lesion. Magnetic resonance images, acquired using fat suppression, fast spin echo, and contrast material injection, depicted seven separate lesions, which were surgically confirmed. 相似文献