四川江油附子生物碱成分的研究

从四川江油附子(Aconitum carmichaeli Debx)中分得六个化合物。经理化常数测定和光谱分析证明,化合物V为新化合物,命名为新江油乌头碱(neojiangyouaconitine)。其余为已知物,分别鉴定为尿嘧啶(Ⅰ),华北乌头碱(Ⅱ),黄草乌头碱(Ⅲ),尼奥灵(Ⅳ),附子亭(Ⅵ)。     

The incidence of hypertension and the effects of a regular high-dose alcohol intake on blood pressure in a medium-sized Hungarian town (Csongrad)

Hypertension screening was carried out on 13,772 adults (74%of the eligible population) in conjunction with X-ray screeningfor tuberculosis in the Hungarian town of Csongrád. Inyoung adults, the blood pressure was found to be higher amongstmen, whilst in older subjects the women had higher blood pressures.Systolic hypertension was detected in one-third of the populationand diastolic hypertension in one-sixth. Of the hypertensivecases detected, 34% were unaware of their disease. Among others,the effects of alcohol intake on blood pressure were investigated.There were 21.4% of the men and 2.3% of the women who admittedto being regular alcohol consumers. Direct and significant correlationswere found between the quantity of alcohol consumed and boththe systolic (p<0.001) and diastolic (p<0.05) blood pressures.The prevalence of hypertension (on the basis of the WHO criteria)was higher in heavy (>80 g ethanol/day) drinkers (29.9%)than in abstinent subjects (20.5% p<0.001). When participantswere subdivided according to age groups, only the men providedsufficient data for a statistical analysis. The systolic bloodpressure of heavy drinkers was higher than that of non-drinkers(y =0.664x + 100.2; y = 0.506x + 114.6; p<0.05).     

妇舒灵胶囊的制备工艺研究

目的：确定妇舒灵胶囊的最佳工艺条件。方法：采用正交设计方法,对制备工艺进行了优化。结果：最佳工艺条件为加水量为生药重的１０ 倍,煎煮２ 次,沸煮６０ｍｉｎ 。结论：本研究实验结果可靠,工艺简单,最佳工艺条件适合批量生产。     

Clinical characteristics and risk factors for peripartum cardiomyopathy

Background

Peripartum cardiomyopathy (PPCM) is a potentially fatal form of heart failure and the recognition of its risk factors is important for prevention and treatment.

Objective

To explore the clinical characteristics and the risk factors for PPCM.

Methods

Echocardiographic was used to examine the left ventricular ejection fraction (LVEF). Blood level of troponin I (cTNI), high sensitive C-reaction protein (hs-CRP), NT-proBNP was measured. All PPCM occurred within weeks following delivery.

Results

Fifty-two PPCM patients and 52 normal delivery subjects (control group) were included in this study. Compared with the control group, PPCM patients were older, with a higher level of blood pressure, and a higher rate of suspected respiratory infection. The level of leucocytes, hs-CRP, cTNI and NT-proBNP in PPCM patients were higher than in the control. Multivariate logistic regression analysis showed that elevated plasma hs-CRP (OR =1.86, p<0.05), respiratory infection (OR = 2.87, p<0.01), and hypertension (OR =1.68, p < 0.05) were independent risk factors for PPCM. During the follow up of 21.6±5.4 d, one patient (1.9%) died probably of heart failure but other patients remained well.

Conclusion

Hypertension, respiratory infection, and elevated plasma hs-CRP seem to be associated with the pathogenesis of peripartum cardiomyopathy in this patient population.     

Lung transplantation from donors after circulatory death using portable ex vivo lung perfusion

BACKGROUND:

Donation after circulatory death is a novel method of increasing the number of donor lungs available for transplantation. Using organs from donors after circulatory death has the potential to increase the number of transplants performed.

METHODS:

Three bilateral lung transplants from donors after circulatory death were performed over a six-month period. Following organ retrieval, all sets of lungs were placed on a portable ex vivo lung perfusion device for evaluation and preservation.

RESULTS:

Lung function remained stable during portable ex vivo perfusion, with improvement in partial pressure of oxygen/fraction of inspired oxygen ratios. Mechanical ventilation was discontinued within 48 h for each recipient and no patient stayed in the intensive care unit longer than eight days. There was no postgraft dysfunction at 72 h in two of the three recipients. Ninety-day mortality for all recipients was 0% and all maintain excellent forced expiratory volume in 1 s and forced vital capacity values post-transplantation.

CONCLUSION:

The authors report excellent results with their initial experience using donors after circulatory death after portable ex vivo lung perfusion. It is hoped this will allow for the most efficient use of available donor lungs, leading to more transplants and fewer deaths for potential recipients on wait lists.     

髋臼三维记忆内固定系统治疗髋臼后壁骨折的有限元分析

目的:探讨髋臼三维记忆内固定系统治疗髋臼后壁骨折及其产生的动态记忆应力促进骨愈合的生物力学基础。方法:实验于2006-01在长海医院进行。利用计算机仿真三维有限元技术,对髋臼记忆内固定系统固定髋臼后壁骨折的生物力学行为进行模拟,BaⅡ型三维有限元模型共划分7946个单元,2520个结点;BbI型三维有限元结构共划分1787个单元,623个结点,单元采用TET4单元;髋臼有限元模型共划分5783个单元,节点数为9863,单元采用10节点四面体三维单元。结果:①变形最大在加压部,BaⅡ型所受最大压应力和张应力分别为228MPa和-24.5MPa,其维持纵向的动态记忆持骨力196N;BbI型所受压应力和张应力分别为108MPa和-4.5kPa,其维持轴向的动态记忆加压力为125.05N,二者皆远小于其极限应力及疲劳极限。②被固定髋臼后壁骨块应力分布均匀,各节点所受应力主要为接近生理载荷的正应力,无论在后壁骨折的上、下及内侧骨折面,骨折断层的应力分布表现为记忆导向孔附近应力较大,为垂直骨折面的压应力(最大压应力7.00MPa),近髋臼窝边缘处骨折面表现为张应力。结论:髋臼记忆内固定系统有良好的耐疲劳与重复使用性,其固定后产生的动态记忆加压应力场,有利于固定髋臼后壁骨折的稳定、预防废用段的发生并促进骨折愈合。     

丝瓜叶中丝瓜皂甙R的化学结构

从丝瓜(Lufa cylindrica Roem.)叶中分得一种新的五环三萜皂甙和丝瓜皂甙G,用光谱和化学方法确定新皂甙的结构为2α,21β-二羟基常春藤皂甙元-3-O-β-D-吡喃葡萄糖甙,命名为丝瓜皂甙R。