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51.
SANTORO T 《Hospital progress》1957,38(1):74; passim
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PRYOR WILLIAM A.; BERMUDEZ ELIEZER; CUETO RAFAEL; SQUADRITO GIUSEPPE L. 《Toxicological sciences》1996,34(1):148-156
We report the detection of hexanal, heptanal, and nonanal inthe bronchoalveolar lavage (BAL) of rats exposed to 0.5 to 10ppm ozone with or without simultaneous 5% CO2. These three aldehydesprimarily result from the Criegee ozonation of specific mono-or polyunsaturated fatty acids that are present in significantamounts in the rat lung; e.g., palmitoleic acid gives heptanal,oleic gives nonanal, and linoleic and arachidonic can give hexanal.Hexanal also is produced in the ozone-initiated autoxidationof any n-6 polyunsaturated fatty acid, and thus is a measureof generalized oxidative stress. (Monounsaturated fatty acidsdo not undergo appreciable autoxidation.) This detection andquantitation of aldehydes directly demonstrates for the firsttime that unsaturated fatty acids undergo Criegee ozonationin the lung when ozone is inhaled. Exposure to ozone alone producedsmaller apparent yields of the three aldehydes than did exposureto ozone plus 5% CO2. Hexanal, heptanal, and nonanal can bedetected in BAL of rats 5 hr after the end of the ozone exposure,but after more than 5 hr only hexanal can be found, probablyfrom ozone-induced autoxidation of n-6 PUFA that continues afterozone exposure. The measured amounts of aldehydes are low, andthat, coupled with inherent biovariability, suggests that aldehydesmay not be useful as quantitative dosimeters. However, theycan be useful biomarkers, since some of these aldehydes (e.g.,nonanal) are produced in ozone-specific pathways and aldehydesare the most easily detected among the lipid ozonation products(LOP). Furthermore, our identification of these aldehydes byBAL, coupled with our recognition that ozone itself cannot penetratefar enough into the lung to cause many of the effects associatedwith the inhalation of ozone, suggests that these aldehydes,as well as other types of LOP (such as hydroxyhydroperoxidesand Criegee ozonides), may act as signal transduction molecules,activating lipases and causing the release of inflammatory moleculesby a variety of pathways not yet entirely elucidated. 相似文献
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Determinants of Efficacy of Atrial Pacing in Preventing Atrial Fibrillation Recurrences 总被引:6,自引:0,他引:6
GIUSEPPE STABILE M.D. GAETANO SENATORE M.D. † ANTONIO De SIMONE M.D. PIETRO TURCO M.D. FERNANDO COLTORTI M.D. † PASQUALE NOCERINO M.D. † DINO FRANCO VITALE M.D. ‡ MASSIMO CHIARIELLO M.D. † 《Journal of cardiovascular electrophysiology》1999,10(1):2-9
Atrial Pacing in Atrial Fibrillation. Introduction: Several studies have shown that single or dual site atrial pacing is effective in reducing he frequency of recurrent atrial fibrillation (AF) in selected patients. However, it is still unclear what the best predictors are of long-term efficacy of atrial pacing. Methods and Results: Forty-seven patients with paroxysmal AF requiring demand pacing underwent electrophysiologic study and dual chamber pacemaker implant. After 4 months of follow-up, patients were divided into two groups according to the presence (group 1) or absence (group 2) of symptomatic AF recurrences. Atrial pacing markedly reduced AF recurrences in all patients. Twenty-four patients were free of arrhythmia. The basal state conduction times (CTs) and the incremental conduction times (ICTs), during programmed electric stimulation between the high right atrium (HRA) and the coronary sinus ostium (CSos) but not between the HRA and the His-bundle region, were significantly longer in group 1. There was no statistical difference in the effective refractory period (ERP) recorded at the HRA, the low right atrium (LRA), and the CSs between the two groups, whereas the differences between the greatest and least recorded ERPs measured from the HRA, LRA, and CSos (δERP) were significantly greater in group 1 patients. Two parameters were selected by discriminant multivariate analysis, namely δCTos (ICT-CT between HRA and CSos and δERP. The first bad a greater relative importance in predicting AF recurrence (r2= 0.33 and r2= O.1, respectively). Conclusion: Single site atrial pacing is effective in reducing AF recurrences, with decreasing efficacy in patients with greater right atrial conduction delay and wider refractoriness dispersion. 相似文献
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CLAUDIA BERNARDINI VALERIA AMBROGI LUANA CRISTINA PERIOLI MARIA CRISTINA TIRALTI GIUSEPPE FARDELLA 《Pharmacological research》2000,41(6):679-688
Directive 92/27EEC establishes that the package leaflet is a document, which must be included in the package of medicinal products for human use in EU countries. This informative leaflet is directed at the users and it must give full and comprehensible information. The Law suggests the use of symbols but it does not give advice about the subjects to be represented. In order to evaluate the attitude of patients towards package leaflets provided with symbols, we planned a survey interviewing 1004 patients in pharmacies. The data suggest that Italian patients usually read the package leaflet but they neither understand it easily nor find the needed information readily. Most respondents (74.3%) considered the use of symbols helpful in finding the needed information. We proposed five symbols for each heading (therapeutic indications, side effects, paediatric use, contraindications, use in pregnancy) and asked to select which symbol could be used. In the case of 'side effects', 'paediatric use', 'use in pregnancy' and 'dose', most of the respondents chose the same symbol. In the case of 'therapeutic indications' and 'contraindications' there was no uniformity in the answers. The choice depends greatly on education, age and employment of respondents. 相似文献
57.
Impact on Prognosis of Periprocedural Myocardial Infarction after Percutaneous Coronary Intervention
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Autoantibodies against β1‐Adrenergic Receptors: Response to Cardiac Resynchronization Therapy and Renal Function 下载免费PDF全文
ANTONIO MICHELUCCI M.D. MARIO MILCO D'ELIOS M.D. ELENA STICCHI Ph.D. PAOLO PIERAGNOLI M.D. GIUSEPPE RICCIARDI M.D. CINZIA FATINI Ph.D. MARISA BENAGIANO Ph.D. ELENA NICCOLAI Ph.D. ALESSIA GRASSI M.Sc. PAOLA ATTANÀ M.D. MARTINA NESTI M.D. GINO GRIFONI M.D. LUIGI PADELETTI M.D. ROSANNA ABBATE M.D. DOMENICO PRISCO M.D. 《Pacing and clinical electrophysiology : PACE》2016,39(1):65-72
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GIUSEPPE CICONTE M.D. JUAN SIEIRA‐MORET M.D. EBRU HACIOGLU M.D. GIACOMO MUGNAI M.D. GIACOMO DI GIOVANNI M.D. VEDRAN VELAGIC M.D. YUKIO SAITOH M.D. GIULIO CONTE M.D. Ph.D. GHAZALA IRFAN M.D. GIANNIS BALTOGIANNIS M.D. Ph.D. BURAK HUNUK M.D. ERWIN STROKER M.D. PEDRO BRUGADA M.D. Ph.D. CARLO DE ASMUNDIS M.D. Ph.D. F.H.R.S. GIAN‐BATTISTA CHIERCHIA M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2016,27(7):796-803
60.
GIUSEPPE INAMA M.D. CLAUDIO PEDRINAZZI M.D. PEDRO ADRAGAO M.D. † MIGUEL ALVAREZ M.D. ‡ FERNANDO ARRIBAS M.D. § DANIEL BONHORST M.D. † LUIS ELVAS M.D. MAURIZIO LANDOLINA M.D. †† JOSÈ L. MERINO M.D. ‡‡ ENRIQUE RODRIGUEZ M.D. §§ JOAO DE SOUSA M.D. MICHELE GULIZIA M.D. ††† 《Pacing and clinical electrophysiology : PACE》2009,32(4):506-515
Background: Radiofrequency catheter ablation is a well-established approach to treating several types of cardiac arrhythmias. The aim of our study was to provide data on the diffusion of catheter ablation procedures in clinical practice through a meta-analysis of National Registries of electrophysiological procedures performed over a 5-year period, from 2000 to 2005.
Methods: We found only two national registries of catheter ablation procedures published in the journals indexed in PubMed: The Spanish Catheter Ablation Registry and the Portuguese National Registry on Cardiac Electrophysiology. In addition, we included in our analysis the data from the Italian Registry of Electrophysiological Procedures.
Results and Conclusions: This meta-analysis revealed a steady increase in the total number of catheter ablation procedures, particularly for the ablation of atrial flutter, of tachycardia due to double nodal pathways, and of the left atrial substrate in atrial fibrillation. However, the progress of catheter ablation and the impetus for additional research and development of new approaches and technologic advances requires further data on clinical indications, methodologic approach, complications, and long-term success rate in the real world. 相似文献
Methods: We found only two national registries of catheter ablation procedures published in the journals indexed in PubMed: The Spanish Catheter Ablation Registry and the Portuguese National Registry on Cardiac Electrophysiology. In addition, we included in our analysis the data from the Italian Registry of Electrophysiological Procedures.
Results and Conclusions: This meta-analysis revealed a steady increase in the total number of catheter ablation procedures, particularly for the ablation of atrial flutter, of tachycardia due to double nodal pathways, and of the left atrial substrate in atrial fibrillation. However, the progress of catheter ablation and the impetus for additional research and development of new approaches and technologic advances requires further data on clinical indications, methodologic approach, complications, and long-term success rate in the real world. 相似文献