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691.
In the present study, there was a complete lack of autologous MLR between responding T cells or T subsets and unirradiated or irradiated leukemic B cells or monocytes in all 20 patients with CLL, regardless of disease status, stage, phenotype, or karyotype of the disease. The stimulating capacity of unirradiated CLL B cells and CLL monocytes or irradiated CLL B cells was significantly depressed as compared to that of respective normal B cells and monocytes in allogeneic MLR. The responding capacity of CLL T cells was also variably lower than that of normal T cells against unirradiated or irradiated normal allogeneic B cells and monocytes. The depressed allogeneic MLR between CLL B cells or CLL monocytes and normal T cells described in the present study could be explained on the basis of a defect in the stimulating antigens of leukemic B cells or monocytes. The decreased allogeneic MLR of CLL T cells might simply be explained by a defect in the responsiveness of T lymphocytes from patients with CLL. However, these speculations do not adequately explain the complete lack of autologous MLR in these patients. When irradiated CLL B cells or irradiated CLL T cells were cocultured with normal T cells and irradiated normal B cells, it was found that there was no suppressor cell activity of CLL B cells or CLL T cells on normal autologous MLR. Our data suggest that the absence or dysfunction of autoreactive T cells within the Tnon-gamma subset account for the lack of autologous MLR in patients with CLL. The possible significance of the autologous MLR, its relationship to in vivo immunoregulatory mechanisms, and the possible role of breakdown of autoimmunoregulation in the oncogenic process of certain lymphoproliferative and autoimmune diseases in man are discussed. 相似文献
692.
Salmon calcitonin nasal spray in the prevention of corticosteroid- induced osteoporosis 总被引:5,自引:0,他引:5
Adachi JD; Bensen WG; Bell MJ; Bianchi FA; Cividino AA; Craig GL; Sturtridge WC; Sebaldt RJ; Steele M; Gordon M; Themeles E; Tugwell P; Roberts R; Gent M 《Rheumatology (Oxford, England)》1997,36(2):255-259
The objectives were to determine the efficacy and safety of nasal salmon
calcitonin 200 IU daily in the prevention of corticosteroid- induced
osteoporosis. A minimized, double-blind, placebo-controlled trial was
carried out in corticosteroid-treated patients with polymyalgia rheumatica.
The setting was a tertiary care university- affiliated hospital and a total
of 31 patients were enrolled. The primary outcome measure was the
percentage change in bone mineral density of the lumbar spine in the two
treatment groups from baseline to 1 yr of follow-up. The mean +/- S.D. bone
mineral density of the lumbar spine in the calcitonin-treated group
decreased by 1.29 +/- 6.76% and in the placebo group by 4.95 +/- 3.50%
after 12 months. The observed difference of 3.65 +/- 2.10% between groups
is statistically significant (P < 0.05). Nasal salmon calcitonin
prevented loss of bone in the lumbar spine as measured by dual-energy X-ray
absorptiometry.
相似文献
693.
Mona Hussein El-Samahy AA Adly Yasmine Ibrahim Elhenawy EA Ismail Shaimaa Abdelmalik Pessar Mohamed El-Sayed Mowafy Mohammed Salah Saad Hossam Hassan Mohammed 《Journal of diabetes and its complications》2018,32(2):185-192