全文获取类型
收费全文 | 1976680篇 |
免费 | 140341篇 |
国内免费 | 3987篇 |
专业分类
耳鼻咽喉 | 28503篇 |
儿科学 | 64857篇 |
妇产科学 | 57532篇 |
基础医学 | 285830篇 |
口腔科学 | 55562篇 |
临床医学 | 167917篇 |
内科学 | 388348篇 |
皮肤病学 | 41682篇 |
神经病学 | 154945篇 |
特种医学 | 77903篇 |
外国民族医学 | 672篇 |
外科学 | 307539篇 |
综合类 | 42222篇 |
现状与发展 | 1篇 |
一般理论 | 525篇 |
预防医学 | 145520篇 |
眼科学 | 45658篇 |
药学 | 147319篇 |
1篇 | |
中国医学 | 3887篇 |
肿瘤学 | 104585篇 |
出版年
2018年 | 18902篇 |
2016年 | 16080篇 |
2015年 | 18429篇 |
2014年 | 25960篇 |
2013年 | 39708篇 |
2012年 | 53857篇 |
2011年 | 57703篇 |
2010年 | 34546篇 |
2009年 | 32641篇 |
2008年 | 55552篇 |
2007年 | 59726篇 |
2006年 | 60628篇 |
2005年 | 59402篇 |
2004年 | 57042篇 |
2003年 | 55371篇 |
2002年 | 54507篇 |
2001年 | 88086篇 |
2000年 | 90525篇 |
1999年 | 77325篇 |
1998年 | 21913篇 |
1997年 | 19805篇 |
1996年 | 19932篇 |
1995年 | 18712篇 |
1994年 | 17810篇 |
1993年 | 16642篇 |
1992年 | 61854篇 |
1991年 | 60454篇 |
1990年 | 59454篇 |
1989年 | 57533篇 |
1988年 | 53724篇 |
1987年 | 52696篇 |
1986年 | 50420篇 |
1985年 | 48143篇 |
1984年 | 36063篇 |
1983年 | 31087篇 |
1982年 | 18678篇 |
1981年 | 16426篇 |
1979年 | 34056篇 |
1978年 | 23944篇 |
1977年 | 20520篇 |
1976年 | 19424篇 |
1975年 | 21359篇 |
1974年 | 25266篇 |
1973年 | 24303篇 |
1972年 | 23124篇 |
1971年 | 21514篇 |
1970年 | 20248篇 |
1969年 | 19216篇 |
1968年 | 18229篇 |
1967年 | 16289篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
Melinda G Arnett Lisa M Muglia Gloria Laryea Louis J Muglia 《Neuropsychopharmacology》2016,41(1):245-260
The normal function of the hypothalamic-pituitary-adrenal (HPA) axis, and resultant glucocorticoid (GC) secretion, is essential for human health. Disruption of GC regulation is associated with pathologic, psychological, and physiological disease states such as depression, post-traumatic stress disorder, hypertension, diabetes, and osteopenia, among others. As such, understanding the mechanisms by which HPA output is tightly regulated in its responses to environmental stressors and circadian cues has been an active area of investigation for decades. Over the last 20 years, however, advances in gene targeting and genome modification in rodent models have allowed the detailed dissection of roles for key molecular mediators and brain regions responsible for this control in vivo to emerge. Here, we summarize work done to elucidate the function of critical neuropeptide systems, GC-signaling targets, and inflammation-associated pathways in HPA axis regulation and behavior, and highlight areas for future investigation. 相似文献
102.
103.
Bj?rn Stessel Audrey A. Fiddelers Elbert A. Joosten Daisy M.N. Hoofwijk Hans-Fritz Gramke Wolfgang F.F.A. Buhre 《Medicine》2015,94(39)
Traditionally, major complications and unanticipated admission/readmission rates were used to assess outcome after day surgery. However, in view of the relative absence of major complications the quality of recovery (QOR) should be considered one of the principal endpoints after day surgery. In our study, the level of QOR is defined by a combination of the Global Surgical Recovery (GSR) Index and the Quality of Life (QOL).The aim of this study was to analyze prevalence and predictors of QOR after day surgery on the fourth postoperative day.Elective patients scheduled for day surgery from November 2008 to April 2010 were enrolled in a prospective cohort study. Outcome parameters were measured by using questionnaire packages at 2 time points: 1 week preoperatively and 4 days postoperatively. Primary outcome parameter is the QOR and is defined as good if the GSR index >80% as well as the postoperative QOL is unchanged or improved as compared with baseline. QOR is defined as poor if both the GSR index ≤80% and if the postoperative QOL is decreased as compared with baseline. QOR is defined as intermediate in all other cases. Three logistic regression analyses were performed to determine predictors for poor QOR after day surgery.A total of 1118 patients were included. A good QOR was noted in 17.3% of patients, an intermediate QOR in 34.8%, and a poor QOR in 47.8% 4 days after day surgery. The best predictor for poor QOR after day surgery was type of surgery. Other predictors were younger age, work status, and longer duration of surgery. A history of previous surgery, expected pain (by the patient) and high long-term surgical fear were significant predictors of poor QOR in only 1 of 3 prediction models.The QOR at home 4 days after day surgery was poor in the majority of patients and showed a significant procedure-specific variation. Patients at risk for poor QOR can be identified during the preoperative period based on type of surgery, age, work status, and the duration of the surgery. 相似文献
104.
105.
106.
107.
108.
109.
I. Fouzas C. Papanikolaou G. Katsanos N. Antoniadis N. Salveridis K. Karakasi S. Vasileiadou A. Fouza E. Mouloudi G. Imvrios V. Papanikolaou 《Transplantation proceedings》2019,51(2):416-420
Aims
Variations of the anatomy of donor hepatic arteries increase the number of arterial anastomoses during liver transplantation and, possibly, the incidence of hepatic artery thrombosis (HAT). In this study, we describe the arterial anatomic variations in liver grafts procured and transplanted by a single center in Greece, the techniques of arterial anastomosis, and their effect on the incidence of early HAT.Materials and Methods
From January 2013 to December 2017, the arterial anatomy of 116 grafts procured for liver transplantation were recorded, as well as the technique of arterial anastomosis and the incidence of early hepatic artery thrombosis (HAT <30 days).Results
A single hepatic artery was recorded in 72.41% of the procured grafts, an aberrant left hepatic artery (accessory or replaced) in 18 grafts (15.52%), and an aberrant right hepatic artery (accessory or replaced) in 17 grafts (14.66%), while other variations were observed in less than 1% of the procured livers. Of the 116 primary liver transplantations, 6 patients (5.17%) developed early HAT <30 days. Two of these patients (1.72%) had 1 anastomosis of the hepatic artery and 4 (3.45%) had 2 anastomoses due to anatomic variations.Conclusions
Anatomic variations of the hepatic artery in liver grafts is a common finding and increase the incidence of early HAT but not to a degree to make these grafts unusable. 相似文献110.
Rotary ventricular assist devices (VADs) are less sensitive to preload than the healthy heart, resulting in inadequate flow regulation in response to changes in patient cardiac demand. Starling‐like physiological controllers (SLCs) have been developed to automatically regulate VAD flow based on ventricular preload. An SLC consists of a cardiac response curve (CRC) which imposes a nonlinear relationship between VAD flow and ventricular preload, and a venous return line (VRL) which determines the return path of the controller. This study investigates the importance of a physiological VRL in SLC of dual rotary blood pumps for biventricular support. Two experiments were conducted on a physical mock circulation loop (MCL); the first compared an SLC with an angled physiological VRL (SLC‐P) against an SLC with a vertical VRL (SLC‐V). The second experiment quantified the benefit of a dynamic VRL, represented by a series of specific VRLs, which could adapt to different circulatory states including changes in pulmonary (PVR) and systemic (SVR) vascular resistance versus a fixed physiological VRL which was calculated at rest. In both sets of experiments, the transient controller responses were evaluated through reductions in preload caused by the removal of fluid from the MCL. The SLC‐P produced no overshoot or oscillations following step changes in preload, whereas SLC‐V produced 0.4 L/min (12.5%) overshoot for both left and right VADs. Additionally, the SLC‐V had increased settling time and reduced controller stability as evidenced by transient controller oscillations. The transient results comparing the specific and standard VRLs demonstrated that specific VRL rise times were improved by between 1.2 and 4.7 s ( = 3.05 s), while specific VRL settling times were improved by between 2.8 and 16.1 seconds ( = 8.38 s) over the standard VRL. This suggests only a minor improvement in controller response time from a dynamic VRL compared to the fixed VRL. These results indicate that the use of a fixed physiologically representative VRL is adequate over a wide variety of physiological conditions. 相似文献