全文获取类型
收费全文 | 11006篇 |
免费 | 549篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 155篇 |
妇产科学 | 215篇 |
基础医学 | 1254篇 |
口腔科学 | 264篇 |
临床医学 | 737篇 |
内科学 | 2698篇 |
皮肤病学 | 163篇 |
神经病学 | 730篇 |
特种医学 | 528篇 |
外科学 | 2039篇 |
综合类 | 66篇 |
预防医学 | 245篇 |
眼科学 | 144篇 |
药学 | 860篇 |
1篇 | |
中国医学 | 21篇 |
肿瘤学 | 1416篇 |
出版年
2023年 | 47篇 |
2022年 | 99篇 |
2021年 | 166篇 |
2020年 | 110篇 |
2019年 | 138篇 |
2018年 | 156篇 |
2017年 | 153篇 |
2016年 | 192篇 |
2015年 | 181篇 |
2014年 | 235篇 |
2013年 | 318篇 |
2012年 | 434篇 |
2011年 | 515篇 |
2010年 | 279篇 |
2009年 | 253篇 |
2008年 | 480篇 |
2007年 | 479篇 |
2006年 | 466篇 |
2005年 | 434篇 |
2004年 | 541篇 |
2003年 | 506篇 |
2002年 | 488篇 |
2001年 | 450篇 |
2000年 | 451篇 |
1999年 | 435篇 |
1998年 | 150篇 |
1997年 | 128篇 |
1996年 | 122篇 |
1995年 | 107篇 |
1994年 | 88篇 |
1993年 | 66篇 |
1992年 | 253篇 |
1991年 | 203篇 |
1990年 | 225篇 |
1989年 | 273篇 |
1988年 | 254篇 |
1987年 | 245篇 |
1986年 | 213篇 |
1985年 | 215篇 |
1984年 | 121篇 |
1983年 | 114篇 |
1982年 | 47篇 |
1979年 | 104篇 |
1978年 | 67篇 |
1977年 | 48篇 |
1974年 | 41篇 |
1972年 | 51篇 |
1971年 | 52篇 |
1970年 | 47篇 |
1969年 | 57篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
151.
152.
Shingen Nakamura Momoyo Azuma Tomoko Maruhashi Kimiko Sogabe Ryohei Sumitani Munenori Uemura Masami Iwasa Shiro Fujii Hirokazu Miki Kumiko Kagawa Takashi Hiraga Noriyasu Kondo Hiromi Fujita Fumihiko Mahara Masahiro Abe 《Journal of infection and chemotherapy》2018,24(5):389-392
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus (SFTSV). Clinical symptoms of SFTS often involve encephalopathy and other central neurological symptoms, particularly in seriously ill patients; however, pathogenesis of encephalopathy by SFTSV is largely unknown. Herein, we present case reports of three patients with SFTS, complicated by encephalopathy, admitted to Tokushima University hospital: one patient was a 63-year-old man, while the other two were 83- and 86-year-old women. All of them developed disturbance of consciousness around the 7th day post onset of fever. After methylprednisolone pulse therapy of 500 mg/day, all of them recovered without any neurological sequelae. SFTSV genome was not detected in the cerebrospinal fluid of 2 out of the 3 patients that were available for examination. In these patients, disturbance of consciousness seemed to be an indirect effect of the cytokine storm triggered by SFTSV infection. We propose that short-term glucocorticoid therapy might be beneficial in the treatment of encephalopathy during early phase of SFTSV infection. 相似文献
153.
154.
155.
156.
Morimasa Sekiguchi Yuzo Fujii Atsuko Saito Toshimitsu Suzuki Yasuko Shiroko Hisayoshi Nakamura Ken-ichiro Hasumi 《Journal of gastroenterology》1995,30(5):589-598
We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity
to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old
male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high serum levels of alpha-fetoprotein. The primary tumor
was moderately differentiated tubular adenocarcinoma and the lymph node was poorly differentiated adenocarcinoma without any
particular pattern. The cultured cells grew as densely packed islet-like colonies with small polygonal cells. Electron microscopy
revealed cells abundant in cytoplasmic organelles, with some cellular attachments being tight with junctional complexes and
some being loose across intercellular spaces. The free cell surface had microvilli. The population doubling-time was 152 h
at passage 58. Chromosomal analysis revealed the modal number to be 77, with numerous karyotype abnormalities. The tumorigenicity
of the cultured cells in athymic nude mice was positive only when they were subcutaneously transplanted beneath a plastic
plate, but when the cells were transplanted subcutaneously or administered by intrasplenic injection in intact or weakly irradiated
nude mice, no tumorigenicty was shown. The cell line produced tumor-associated antigens, such as alpha-fetoprotein, carcinoembryonic
antigen, and tissue polypeptide antigen. This cell line may be useful for comparative studies of different types of gastric
carcinoma and alpha-fetoproteins of different origins. 相似文献
157.
158.
Association between anomalous pancreaticobiliary ductal union and adenomyomatosis of the gall-bladder 总被引:2,自引:0,他引:2
Tanno S Obara T Maguchi H Fujii T Mizukami Y Shudo R Takahashi K Nishino N Arisato S Ura H Kohgo Y 《Journal of gastroenterology and hepatology》1998,13(2):175-180
A frequent association of biliary tract carcinoma and anomalous pancreaticobiliary ductal union (APBD) is well recognized, especially gall-bladder carcinoma in undilated type APBD. However, little is known about the presence and incidence of adenomyomatosis (AMT) of the gall-bladder, a presumed premalignant lesion, in patients with APBD. This retrospective study was conducted to elucidate the clinical features and incidence of AMT in APBD patients with relation to undilated type and dilated type APBD. We reviewed the clinicopathological records of 30 patients with APBD (28 women and two men) encountered during the past 10 years. Among them, 22 patients underwent cholecystectomy and the resected specimens were subjected to histopathological examinations. Eleven cases of APBD patients were undilated type and 11 cases were dilated type. Adenomyomatosis was found in six (55%) of 11 undilated type and one (9%) of 11 dilated type, and fundal type was predominantly observed in six (86%) of seven AMT. An overall incidence of AMT in APBD patients was 32%. An undilated type of APBD is frequently associated with AMT and we believe, therefore, that clinicians should be aware of a possible coexistence of APBD and AMT. 相似文献
159.
Hasegawa T Ishihara K Takakura S Fujii H Nishimura T Okazaki M Katakami N Umeda B 《Internal medicine (Tokyo, Japan)》2000,39(10):794-797
OBJECTIVE: To determine an appropriate duration for a short course of oral steroids in cases of asthma exacerbations. SETTING: A 1,000 bed city hospital in Kobe, Japan. PATIENTS: Patients with asthma exacerbations who needed hospital admission. METHODS: Following an initial treatment with a 3-day course of intravenous methylprednisolone, patients were allocated to either a 1-week (1 W) or a 2-week (2 W) course of oral prednisolone (PSL, 0.5 mg/kg). OUTCOME MEASURES: Peak expiratory flow rate (PEF) and rate of unscheduled hospital visits and readmission. RESULTS: Twenty patients were enrolled (10 in 1 W, 10 in 2 W). Mean PEF just before starting oral PSL in 1 W and 2 W were 51 and 58% of each patient's best value. PEF was significantly improved and to a similar degree over the course of time in both 1 W and 2 W. The frequency of unexpected hospital visits during a 3-month period after discharge was similar (2 in 1 W and 2 in 2 W). No readmission occurred during the same period. CONCLUSIONS: Because both the 1-week and the 2-week course of oral PSL were equally effective in the treatment of asthma exacerbations, 1 week may be appropriate as the maximum duration of a short rescue course of oral steroids. 相似文献
160.
Noninvasive assessment of left and right ventricular filling in myocardial infarction with a two-dimensional Doppler echocardiographic method 总被引:3,自引:0,他引:3
J Fujii Y Yazaki H Sawada T Aizawa H Watanabe K Kato 《Journal of the American College of Cardiology》1985,5(5):1155-1160
Inflow characteristics of left and right ventricular filling were assessed in 40 patients with myocardial infarction and in 10 normal subjects by pulsed Doppler echocardiography. Patients with myocardial infarction were subdivided into four groups, focusing on the involvement of right ventricular and septal branches of the coronary arteries. Group I consisted of 11 patients with anterior infarction who showed an obstructive lesion of the proximal left anterior descending branch involving the first septal perforator with a patent right coronary artery. Group II consisted of 10 patients with inferior infarction who showed an obstructive lesion of the proximal right coronary artery involving the right ventricular branch. Group III consisted of 12 patients with both anterior and inferior infarction who showed obstructive lesions of both the proximal left anterior descending branch and the right coronary artery involving the right ventricular branch. Group IV consisted of seven patients with lateral infarction who showed an obstructive lesion of the diagonal branch or branches of the circumflex coronary artery with a patent left anterior descending branch and right coronary artery. Three measurements were performed from the transmitral and transtricuspidal inflow velocity patterns to assess the left and right ventricular diastolic behaviors. These measurements were: acceleration half-time, deceleration half-time of early diastolic rapid inflow, and the ratio of the peak velocity of early diastolic rapid inflow to that of the late diastolic inflow due to the atrial contraction. Impaired diastolic filling of the left ventricle compensated by enhanced left atrial contraction was observed in patients with myocardial infarction from groups I, II, III and IV.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献