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61.
Hong Liang TEY Hock Leong EE Andy SL TAN Thiam Seng THENG Su Ni WONG Shih Wee KHOO 《The Journal of dermatology》2010,37(5):426-430
The aim of this study was to determine if the following characteristics were associated with the presence of psoriatic arthritis in a sample of psoriasis patients: race, family history of psoriasis and psoriatic arthritis, age of onset of psoriasis, smoking, alcohol consumption and the maximum body surface area (BSA) affected by psoriasis. This was a case–control study involving 400 psoriasis patients who attended the Psoriasis and Photo‐medicine clinic in the National Skin Center of Singapore over a 1‐year period. Cases were psoriasis patients with psoriatic arthritis while controls were psoriasis patients without psoriatic arthritis. The diagnosis of psoriatic arthritis was made by rheumatologists and participants completed a self‐administered standardized questionnaire. The maximum BSA involved was determined from the case notes. Psoriatic arthritis was not significantly associated with sex, race, age of onset of psoriasis, a family history of psoriasis, smoking and alcohol consumption but was significantly associated with a family history of psoriatic arthritis (P < 0.001) and the maximum body surface involved (P = 0.05). Using multivariate analysis to control for variables, the presence of psoriatic arthritis was significantly associated with a family history of psoriatic arthritis (odds ratio [OR] = 20.5; 95% confidence interval [CI] = 2.49–169.10) and the maximum BSA involved (OR = 2.52; 95% CI = 1.33–4.75). Indian psoriatic patients were more likely to have psoriatic arthritis compared to the other races. A family history of psoriatic arthritis and a greater maximum body surface involved may be associated with having psoriatic arthritis in this study population of psoriasis patients. 相似文献
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Fryzek JP Mellemkjaer L Friis S McLaughlin JK Rosenthal AK Blot WJ Olsen JH 《The Journal of rheumatology》2000,27(6):1434-1436
OBJECTIVE: To determine if finger and hand joint prostheses or temporomandibular joint (TMJ) implants may be involved in the initiation of specific connective tissue diseases (CTD), a nationwide cohort in Denmark was followed prospectively to evaluate rates of CTD after receiving these implants. METHODS: Danish patients with finger and hand joint implants (n = 562) or TMJ implants (n = 351) were identified and followed for subsequent hospitalizations. Observed numbers of hospitalizations due to CTD were compared with expected numbers based on national CTD hospitalization rates. To avoid confounding by indication, patients with a hospital discharge diagnosis of a CTD prior to prosthetic surgery were excluded from the cohort. RESULTS: After 4142 person-years of followup in the finger and hand joint cohort, 9 hospitalizations due to CTD were found [standard hospitalization rate (SHR) = 1.5; 95% CI 0.7-2.9]. The TMJ cohort had 1500 person-years of followup and 2 hospitalizations due to CTD (SHR = 1.3; 95% CI 0.2-4.5). CONCLUSION: This is the first cohort study to examine the relations between these implants and CTD. Although the number of events was small, this systematic national study revealed no significant or large increase in risk of CTD after finger and hand joint implants or TMJ implants. 相似文献
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SL Stuckey EJ Gilford PJ Smith M Kean 《Journal of Medical Imaging and Radiation Oncology》1995,39(4):350-355
This preliminary study was designed to investigate the ability of multiple axial volume three-dimensional fourier transform (3DFT) time-of-flight (TOF) magnetic resonance angiography (MRA) to depict the carotid bifurcation in the early post-carotid endarterectomy period. Five patients underwent intra-operative digital subtraction angiography (DSA) and carotid MRA within 5 days of carotid endarterectomy. An axial volume fast imaging in steady-state precession (FISP) gradient-echo 3DFT TOF carotid MRA technique in this limited series appeared to display accurately the surgically significant abnormalities at the carotid bifurcation after endarterectomy. However, in normal or near-normal intra-operative DSA studies, overestimation of internal carotid artery stenoses was encountered. Postoperative MRA demonstrates potential as a useful non-invasive investigation after carotid endarterectomy but should be interpreted with caution until larger studies become available. 相似文献
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Smoking Is a Risk Factor for Recurrence of Groin Hernia 总被引:15,自引:0,他引:15
Sorensen LT Friis E Jorgensen T Vennits B Andersen BR Rasmussen GI Kjaergaard J 《World journal of surgery》2002,26(4):397-400
Studies of connective tissue from
patients with inguinal hernia have shown that smoking may be associated
with hernia formation due to a defective connective tissue metabolism.
Whether smoking is a risk factor for recurrence, too, was examined in
this study. From December 1990 through December 1995, 649 patients
underwent hernia repair as open sutured repair (Cooper ligament or
abdominal ring repair) or as open mesh repair. Five hundred forty-four
eligible patients were evaluated for recurrence 2 years
postoperatively. Association between recurrence and 17 patient-,
disease-, and intraoperative variables were analyzed by multiple
logistic regression. The results showed that smoking was significantly
and independently associated with recurrence compared to nonsmoking
[odds ratio (OR = 2.22; 95% confidence interval (95% CI) =
1.19–4.15)]. Open sutured repair compared to open mesh repair was the
most significant predictor for recurrence (OR = 7.23; 95% CI
= 3.01–17.37). Surprisingly, local anesthesia was associated with a
higher risk of recurrence compared to general anesthesia (OR =
2.44; 95% CI = 1.19–5.09). Potential confounders and other risk
factors for hernia recurrence such as age, alcohol consumption,
previous surgery, and anatomical characteristics of the hernia were
adjusted for in the analysis. In conclusion, smoking is an important
risk factor for recurrence of groin hernia, presumably due to an
abnormal connective tissue metabolism in smokers. 相似文献
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Most – if not all – proteins are bound to interact with other proteins to exert their function, and thus the identification
of the interaction partners of a protein is vital in proteomics. The yeast two-hybrid system is a popular and effective tool
for studyingprotein–protein interactions. Although the advantages of the system are manifold, it also has certain drawbacks
and limitations. The two-hybrid system has been shown to be extremely useful for placing a protein of unknown function within
a functional context, thereby providing information about a putative role of the uncharacterised protein. This concept has
also been successfully applied in molecular gerontology.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献