全文获取类型
收费全文 | 1958篇 |
免费 | 129篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 155篇 |
妇产科学 | 22篇 |
基础医学 | 218篇 |
口腔科学 | 50篇 |
临床医学 | 175篇 |
内科学 | 521篇 |
皮肤病学 | 27篇 |
神经病学 | 35篇 |
特种医学 | 502篇 |
外科学 | 126篇 |
综合类 | 35篇 |
预防医学 | 78篇 |
眼科学 | 13篇 |
药学 | 62篇 |
中国医学 | 3篇 |
肿瘤学 | 82篇 |
出版年
2022年 | 6篇 |
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 12篇 |
2018年 | 20篇 |
2017年 | 16篇 |
2016年 | 25篇 |
2015年 | 37篇 |
2014年 | 30篇 |
2013年 | 67篇 |
2012年 | 31篇 |
2011年 | 30篇 |
2010年 | 86篇 |
2009年 | 64篇 |
2008年 | 55篇 |
2007年 | 49篇 |
2006年 | 51篇 |
2005年 | 43篇 |
2004年 | 38篇 |
2003年 | 36篇 |
2002年 | 38篇 |
2001年 | 24篇 |
2000年 | 27篇 |
1999年 | 38篇 |
1998年 | 137篇 |
1997年 | 120篇 |
1996年 | 127篇 |
1995年 | 94篇 |
1994年 | 76篇 |
1993年 | 86篇 |
1992年 | 29篇 |
1991年 | 30篇 |
1990年 | 20篇 |
1989年 | 64篇 |
1988年 | 51篇 |
1987年 | 56篇 |
1986年 | 48篇 |
1985年 | 54篇 |
1984年 | 27篇 |
1983年 | 33篇 |
1982年 | 34篇 |
1981年 | 20篇 |
1980年 | 38篇 |
1979年 | 16篇 |
1978年 | 16篇 |
1977年 | 20篇 |
1976年 | 24篇 |
1975年 | 24篇 |
1965年 | 3篇 |
1956年 | 5篇 |
排序方式: 共有2110条查询结果,搜索用时 10 毫秒
81.
82.
83.
KAP Meeuwis JA De Hullu MEA De Jager LFAG Massuger PCM Van De Kerkhof MM Van Rossum 《Journal of the European Academy of Dermatology and Venereology》2010,24(12):1425-1430
Background Psoriatic lesions may involve nearly all sites of the body. Involvement of the genital skin is frequently classified as part of intertriginous psoriasis without special awareness and treatment for this presentation of the disease. Gaining knowledge about the frequency of the involvement of genital skin in these patients will improve the overall care for patients with psoriasis. Objectives We studied the prevalence of genital psoriasis in the Netherlands and epidemiological characteristics of this specific presentation of the disease. Furthermore, we studied the relation between flexural and genital psoriasis. Patients/Methods A self‐administered questionnaire was sent to all 5300 members of the Dutch Psoriasis Society. Sociodemographic patient characteristics and disease‐related data (such as localization of psoriatic lesions, involvement of the genitalia, age at onset of genital psoriasis and severity of genital psoriatic lesions) were collected and analysed. Results A response rate of 37% was achieved. Almost 46% of the responding patients with psoriasis, that is 16.5% of all potential responders (n = 5300), report genital involvement at some time during the course of their disease. The genitalia can become affected at any age. Many patients with current genital involvement (38%) do not have the flexural skin affected. Conclusions A large part of patients with psoriasis suffer from genital psoriasis, which was not associated with flexural involvement in at least one third of them. More attention to the genital region is required in the current standard treatment of both male and female psoriatic patients at any age. 相似文献
84.
85.
86.
87.
Dios Castro E Maquet Dusart JA 《Archivos de la Sociedad Espa?ola de Oftalmología》2000,75(11):775-778
PURPOSE/METHOD: We present a case of a patient who developed recurrent epithelial herpes simplex keratitis after starting treatment with latanoprost. Her ophthalmic history was only remarkable for a past episode of herpetic keratitis 21 years previously. RESULTS/CONCLUSIONS: Episodes of herpetic keratitis were under remission only when latanoprost was discontinued. No recurrences of herpes simplex keratitis have been observed since then. Latanoprost usage might be associated with recurrent episodes of herpes simplex keratitis in patients with previous history of ocular herpes simplex virus infection. 相似文献
88.
Magnetic resonance neurography of peripheral nerve following experimental crush injury, and correlation with functional deficit 总被引:14,自引:0,他引:14
OBJECT: In a number of clinical studies magnetic resonance (MR) neurography has been used to examine patients with peripheral nerve damage, but little is understood about the sequence of imaging changes following nerve injuries, and how they correlate with functional deficit. The goal of this study was to further understanding of these changes and their implications. METHODS: Using the rat sciatic nerve crush model, the sciatic nerve was imaged at intervals over 70 days in 12 rats. Sham-operated contralateral nerves served as controls. A 4.7-tesla MR imager with a custom-made surface coil was used. The T2 maps were calculated from images obtained at four echo times and from regions of interest designated on the nerve at three sites. Walking-track analysis was performed at the same intervals as imaging. Magnetic resonance neurography revealed a mean T2 of normal sciatic nerve of 36 msec (standard deviation [SD] 1.2 msec). Crushed nerves demonstrated a sequence of changes in signal intensity that were maximal at 14 days, with a mean T2 of 64 msec (SD 5.2 msec), then falling to a T2 of 53 msec (SD 3.7 msec). Sham-operated nerves had a short and nonsustained rise in signal at 7 days. Walking-track analysis revealed maximum deficit immediately postinjury, with an improvement in function approaching that of control nerves at 30 days. CONCLUSIONS: In this study the authors demonstrate that quantitative assessment of nerve signals with MR neurography allows the sequence of events following nerve crush injury to be followed in vivo, and that a return toward a normal signal correlates with functional improvement. Assessment of peripheral nerve injury in patients by using MR neurography has the potential to confirm acute nerve injury as well as to monitor the recovery process. 相似文献
89.
Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex 总被引:3,自引:0,他引:3
Chan S Kachilele S McCabe CJ Tannahill LA Boelaert K Gittoes NJ Visser TJ Franklyn JA Kilby MD 《Brain research. Developmental brain research》2002,138(2):109-116
Thyroid hormones are known to be important for optimal development of the human central nervous system. Classically, maternal thyroid hormones have not been thought to have a major role in defining central nervous system development. However, recent epidemiological evidence has indicated that subtle deficiencies in circulating maternal thyroid hormones in the first trimester of pregnancy are associated with adverse neurodevelopment. We have used real time PCR to quantitate the expression of mRNAs encoding the thyroid receptor isoforms (TR alpha1, alpha2, beta1 and beta2) and thyronine deiodinase subtypes (5'-DI, 5'-DII and 5-DIII) in human fetal cerebral cortex from the first and second trimesters of pregnancy. Deiodinase subtype activities have also been determined in these tissues and compared to 'normal' adult human cerebral cortex. Iodothyronine deiodinase mRNAs were expressed in human fetal cerebral cortex from 7 to 8 weeks of gestation. The expression of 5'-DI mRNA was variable in fetal life but increased relative to adult cortex (P<0.05), whereas the activity of this enzyme was below the level of assay detection. 5'-DII mRNA and activity in fetal cerebral cortex was detectable from as early as 7-8 weeks but not significantly different from that in adult life except at 15-16 weeks when mRNA expression increased (P<0.05). Fetal cortex 5-DIII mRNA expression was present from the early first trimester but less abundant than in adult tissue (P<0.01) and 5-DIII activity appeared greater in fetal cortex (P<0.01) as compared to adults. Only TR alpha1 mRNA was more abundantly expressed in fetal cortex than adult tissues (P<0.01). In contrast, the TR isoforms (alpha2 and beta1) were expressed significantly less than in adult tissues (P<0.05). Only 26% of fetal cerebral cortex samples expressed TR beta 1. There is evidence that the developing fetal brain, as early as the first trimester, expresses TRs and exhibits the mechanisms of pre-receptor control of thyroid hormone supply. 相似文献
90.
Monge-Argiles J Maloteaux J Van Den Bergh P Sindic C 《Neurología (Barcelona, Spain)》2002,17(2):110-112
We report a patient with a peripheral neuropathy as the first symptom of sarcoidosis. The systemic illness was proved by the presence of typic granulomes in the bone marrow. The fact that sarcoidosis is the cause for the neuropathy is supported by the temporary relation and by the good response of all clinical picture to the corticosteroid therapy.Sarcoid neuropathy can rarely be the presenting feature of sarcoidosis. 相似文献