全文获取类型
收费全文 | 3832篇 |
免费 | 237篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 86篇 |
妇产科学 | 70篇 |
基础医学 | 539篇 |
口腔科学 | 42篇 |
临床医学 | 428篇 |
内科学 | 849篇 |
皮肤病学 | 115篇 |
神经病学 | 432篇 |
特种医学 | 121篇 |
外国民族医学 | 1篇 |
外科学 | 566篇 |
综合类 | 11篇 |
预防医学 | 174篇 |
眼科学 | 54篇 |
药学 | 237篇 |
中国医学 | 6篇 |
肿瘤学 | 314篇 |
出版年
2023年 | 29篇 |
2022年 | 39篇 |
2021年 | 109篇 |
2020年 | 72篇 |
2019年 | 118篇 |
2018年 | 123篇 |
2017年 | 74篇 |
2016年 | 75篇 |
2015年 | 98篇 |
2014年 | 144篇 |
2013年 | 180篇 |
2012年 | 276篇 |
2011年 | 306篇 |
2010年 | 150篇 |
2009年 | 161篇 |
2008年 | 237篇 |
2007年 | 227篇 |
2006年 | 199篇 |
2005年 | 222篇 |
2004年 | 202篇 |
2003年 | 182篇 |
2002年 | 175篇 |
2001年 | 49篇 |
2000年 | 62篇 |
1999年 | 64篇 |
1998年 | 37篇 |
1997年 | 25篇 |
1996年 | 20篇 |
1995年 | 33篇 |
1994年 | 15篇 |
1993年 | 16篇 |
1992年 | 33篇 |
1991年 | 32篇 |
1990年 | 26篇 |
1989年 | 31篇 |
1988年 | 14篇 |
1987年 | 23篇 |
1986年 | 19篇 |
1985年 | 13篇 |
1984年 | 11篇 |
1983年 | 15篇 |
1979年 | 11篇 |
1977年 | 11篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1974年 | 8篇 |
1971年 | 14篇 |
1970年 | 9篇 |
1969年 | 8篇 |
1965年 | 7篇 |
排序方式: 共有4082条查询结果,搜索用时 656 毫秒
131.
BackgroundA better understanding of the environmental factors leading to inflammatory bowel disease should help to prevent occurrence of the disease and its relapses.AimTo review current knowledge on dietary risk factors for inflammatory bowel disease.MethodsThe PubMed, Medline and Cochrane Library were searched for studies on diet and risk of inflammatory bowel disease.ResultsEstablished non-diet risk factors include family predisposition, smoking, appendectomy, and antibiotics. Retrospective case–control studies are encumbered with methodological problems. Prospective studies on European cohorts, mainly including middle-aged adults, suggest that a diet high in protein from meat and fish is associated with a higher risk of inflammatory bowel disease. Intake of the n-6 polyunsaturated fatty acid linoleic acid may confer risk of ulcerative colitis, whereas n-3 polyunsaturated fatty acids may be protective. No effect was found of intake of dietary fibres, sugar, macronutrients, total energy, vitamin C, D, E, Carotene, or Retinol (vitamin A) on risk of ulcerative colitis. No prospective data was found on risk related to intake of fruits, vegetables or food microparticles (titanium dioxide and aluminium silicate).ConclusionsA diet high in protein, particular animal protein, may be associated with increased risk of inflammatory bowel disease and relapses. N-6 polyunsaturated fatty acids may predispose to ulcerative colitis whilst n-3 polyunsaturated fatty acid may protect. These results should be confirmed in other countries and in younger subjects before dietary counselling is recommended in high risk subjects. 相似文献
132.
133.
Mohammad Neaz Morshed Nemeshwaree Behary Nabil Bouazizi Julien Vieillard Jinping Guan Franck Le Derf Vincent Nierstrasz 《RSC advances》2020,10(22):13155
In this study, a flexible multifunctional fibrous membrane for heterogeneous Fenton-like removal of organic and pathogenic contaminants from wastewater was developed by immobilizing zerovalent iron nanoparticles (Fe-NPs) on an amine/thiol grafted polyester membrane. Full characterization of the resulting polyester membranes allowed validation of successful grafting of amine/thiol (NH2 or SH) functional groups and immobilization of Fe-NPs (50–150 nm). The Fenton-like functionality of iron immobilized fibrous membranes (PET–Fe, PET–Si–NH2–Fe, PET–NH2–Fe, and PET–SH–Fe) in the presence of hydrogen peroxide (H2O2) was comparatively studied in the removal of crystal violet dye (50 mg L−1). The effect of pH, amount of iron and H2O2 concentration on dye removal was systematically investigated. The highest dye removal yield reached 98.87% in 22 min at a rate constant 0.1919 min−1 (R2 = 95.36) for PET–SH–Fe providing 78% toxicity reduction assessed by COD analysis. These membranes could be reused for up to seven repeated cycles. Kinetics and postulated mechanism of colour removal were proposed by examining the above results. In addition, the resultant membranes showed substantial antibacterial activity against pathogenic bacteria (Staphylococcus epidermidis, Escherichia coli) strains studied through disc diffusion-zone inhibitory and optical density analysis. These findings are of great importance because they provide a prospect of textile-based flexible catalysts in heterogeneous Fenton-like systems for environmental and green chemistry applications.Multifunctional fibrous membrane for heterogeneous Fenton-like removal of organic and pathogenic contaminants from wastewater was developed by immobilizing zerovalent iron nanoparticles (Fe-NPs) on an amine/thiol grafted polyester membrane. 相似文献
134.
Eloy Cardenas-Montemayor Jan Felix Hartl Maya B. Wolf Franck Marie Leclère Jens Dreyhaupt Peter Hahn Frank Unglaub 《Archives of orthopaedic and trauma surgery》2013,133(2):287-293
Purpose
The purpose of this study was to determine functional and subjective results of patients who received arthroscopic debridement for their TFCC Palmer 1B lesions and to compare their results with those of arthroscopic suture repair.Methods
Between March 2007 and August 2011, 36 patients were diagnosed with Palmer type 1B tears and underwent arthroscopic debridement. 31 patients (15 males and 16 females) were followed up for an average of 26.7 months (±17.4 months) postoperatively. Their average age was 36.7 years (±12.7 years). Follow-up included the determination of range of motion (ROM), grip strength, pain, and wrist scores (modified Mayo wrist score (MMWS), Disabilities of the Arm, Shoulder and Hand questionnaire (DASH score)).Results
Postoperative ROM averaged 99.2 % for the extension/flexion arc, 95.5 % for the radial/ulnar deviation arc, and 99.4 % for the pronation/supination arc of motion when compared with the contralateral wrist. The MMWS was rated excellent in 48 % of patients, good in 39 %, fair in 13 %, and poor in 0 %. The average DASH score was 17.02 (±14.92). There was a significant reduction in pain. The grip strength was 96.7 % (±15.8), pulp-to-pulp pinch 101.9 % (±17.4), and the ulnar variance ?0.12 ± 1.69 mm.Conclusions
Arthroscopic debridement of Palmer type 1B lesions in stable DRUJ yields satisfactory to excellent results. Our study showed similar results compared with the studies of arthroscopic suture repair with shorter postoperative care and fewer complications. 相似文献135.
David Moszkowicz Roberto Arienzo Idir Khettab Gabriel Rahmi Franck Zinzindohoué Anne Berger Jean-Marc Chevallier 《Obesity surgery》2013,23(5):676-686
Background
Laparoscopic sleeve gastrectomy (LSG) is widely adopted but exposes serious complications.Methods
A retrospective database analysis was done to study LSG staple line complications in a tertiary referral university center with surgical ICU experienced in treatment of morbid obesity and complications. Twenty-two consecutive patients were referred between January 2004 and February 2012 with postoperative gastric leak or stenosis after LSG. Interventions consisted in the control of intra-abdominal and general sepsis; restoration of staple line continuity or revision of LSG; nutritional support; treatment of associated complications. Main outcome measures concerned success rates of therapeutic strategies, morbidity and mortality rates, LOS, and time to cure.Results
Thirteen patients (59 %) were referred after failure of reoperation (seven fistula repairs were attempted). Three patients received emergency surgery in our center with transorificial intubation and jejunostomy formation. An endoscopic stent was tried in nine patients but failed in 84.6 % of cases within 20 days (1–161). Seven patients (32 %) necessitated total gastrectomy within 217 days (0–1,915 days) for conservative treatment failure. Procedures under general anesthesia were required in 41 % of cases, organ failure was found in 55 % of cases, and central venous device infection in 40 %. Mortality rate was 4.5 % (n?=?1). Patients with unfavorable evolution of LSG complications (death or additional gastrectomy) had more previous bariatric procedure (82 % vs. 18 %, p?=?0.003). Median time to cure was 310 days (9–546 days).Conclusions
LSG exposes severe complications occurring in patients with benign condition. Endoscopic stents entail high failure rate. Total gastrectomy is required in one third of the cases. 相似文献136.
Alexandra Masson-Lecomte Laurent Guy Philippe Pedron Franck Bruyere Morgan Rouprêt Bonaventure Nsabimbona Mickael Dahan Patrice Hoffman Laurent Salomon Dimitri Vordos Andras Hoznek Philippe Le Corvoisier Pierrick Morel Claude Abbou Alexandre de la Taille 《World journal of urology》2013,31(2):339-343
Purpose
At the time of castration resistance, it is recommended to realize hormonal manipulations before chemotherapy. We evaluated the impact of a switch from GnRH agonist to antagonist in patients with castration-resistant prostate cancer on PSA and testosterone levels at 3 months.Methods
Retrospectively, 17 patients from 5 different centers undergoing androgen deprivation therapy and presenting rising PSA confirmed on 3 blood samples 2 weeks apart and despite a castrate testosterone level (<0.5 ng/ml) were reviewed. Antiandrogen withdrawal syndrome had been tested before the switch. Degarelix was administered as followed: 240 mg for the first injection and then 80 mg every month, subcutaneously. We evaluated the PSA and testosterone level variation 3 months after the switch. Patients who experienced a variation in PSA of less than 10% compared to the baseline or who had a more than 10% PSA decrease were defined as responders.Results
Mean PSA level at the switch was 34.3 ± 50.3 ng/ml, with a mean testosterone level of 0.21 ± 0.13 ng/ml. Three months after the switch, mean PSA level was 59.9 ± 81.6 ng/ml (P = 0.061), with a mean testosterone level of 0.19 ± 0.08 ng/ml (P = 0.086). At 3 months, 4 patients (23%) responded to therapy. Thirteen patients (77%) experienced a rise in PSA of more than 10% compared to baseline; 41% of patients decreased their testosterone level. The limitations of this study are its retrospective nature and the limited number of patients.Conclusion
Switch from an agonist to an antagonist of GnRH has a limited impact on PSA at 3 months in castration-resistant prostate cancer patients. 相似文献137.
Franck Billmann Therezia Bokor-Billmann Claude Burnett Erhard Kiffner 《World journal of surgery》2013,37(8):1988-1995
Background
The odontoid lateral mass interspace (OLMI) is the space between the lateral aspect of the dens axis and the medial circumference of the massa lateralis atlantis. The position of OLMI asymmetry as a normal variant or pathologic finding is an area of debate and clinical interest in trauma patients. We designed this prospective study to lay a framework for proposing strategies for the appropriate use of OLMI.Methods
A total of 301 adult patients admitted for trauma were included. Computed tomography (CT) and magnetic resonance imaging (MRI) of the cervical spine were performed and examined for the presence OLMI asymmetry and bony/ligamentous lesions of the occipitoatlantoaxial complex.Results
Head rotation is linked to the occurrence of OLMI asymmetry. Reliable OLMI asymmetry evaluation is limited by observer agreement under a threshold value of 1.0 mm. In all, 86 patients (28.6 %) were found to have OLMI asymmetry on CT after trauma. Among these patients, 17.4 % had a bony/ligamentous lesion of the occipitoatlantoaxial complex. Among the patients without OLMI asymmetry, 8.8 % were found to have such lesions.Conclusions
OLMI asymmetry should only be investigated by CT scans of the head in optimal position and with the threshold value of 1.0 mm. OLMI asymmetry should not be used alone as a sign of a cervical spine lesion. MRI should be performed if: (1) the physician has a high degree of suspicion of a cervical spine lesion; (2) OLMI asymmetry was demonstrated on a technically adequate CT scan; (3) clinical symptoms persist in patients with OLMI asymmetry when no acute MRI was performed. 相似文献138.
139.
140.
Marc Laine Richard Toesca Julie Berbis Corinne Frere Pierre Barnay Michel Pansieri Jean-Pascal Peyre Pierre Michelet Jacques Bessereau Elise Camilleri Olfa Helaf Marjorie Camaleonte Franck Paganelli Françoise Dignat-George Laurent Bonello 《Thrombosis research》2013