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排序方式: 共有501条查询结果,搜索用时 46 毫秒
91.
LG Hamburg 《MedR Medizinrecht》2001,19(1):46-46
Ohne Zusammenfassung 相似文献
92.
LG Bochum 《MedR Medizinrecht》2009,27(2):95-98
Zusammenfassung Die Geltendmachung von Schadensersatz gegen einen Sachverst?ndigen gem. § 839a BGB setzt
eine detaillierte Auseinandersetzung mit dem Inhalt des Gutachtens voraus und erfordert einen substantiierten
Sachvortrag zu der vorgetragenen Behauptung einer vors?tzlichen bzw. grob fahrl?ssigen Erstattung
eines unrichtigen Gutachtens. Lediglich subjektive Zweifel an der Richtigkeit des Gutachtens begründen
noch keinen Anspruch. (Leitsatz der Bearbeiterin) 相似文献
93.
Mikael Montelius Oscar Jalnefjord Johan Spetz Ola Nilsson Eva Forssell‐Aronsson Maria Ljungberg 《NMR in biomedicine》2019,32(3)
Early non‐invasive tumour therapy response assessment requires methods sensitive to biological and physiological tumour characteristics. The aim of this study was to find and evaluate magnetic resonance imaging (MRI) derived tumour tissue parameters that correlate with histological parameters and that reflect effects of radionuclide therapy. Mice bearing a subcutaneous human small‐intestine neuroendocrine tumour were i.v. injected with 177Lu‐octreotate. MRI was performed (7 T Bruker Biospec) on different post‐therapy intervals (1 and 13 days) using T2‐weighted imaging, mapping of T2* and T1 relaxation time constants, as well as diffusion and dynamic contrast enhancement (DCE‐MRI) techniques. After MRI, animals were killed and tumours excised. Four differently stained histological sections of the most central imaged tumour plane were digitized, and segmentation techniques were used to produce maps reflecting fibrotic and vascular density, apoptosis, and proliferation. Histological maps were aligned with MRI‐derived parametric maps using landmark‐based registration. Correlations and predictive power were evaluated using linear mixed‐effects models and cross‐validation, respectively. Several MR parameters showed statistically significant correlations with histological parameters. In particular, three DCE‐MRI‐derived parameters reflecting capillary function additionally showed high predictive power regarding apoptosis (2/3) and proliferation (1/3). T1 could be used to predict vascular density, and perfusion fraction derived from diffusion MRI could predict fibrotic density, although with lower predictive power. This work demonstrates the potential to use multiparametric MRI to retrieve important information on the tumour microenvironment after radiotherapy. The non‐invasiveness of the method also allows longitudinal tumour tissue characterization. Further investigation is warranted to evaluate the parameters highlighted in this study longitudinally, in larger studies, and with additional histological methods. 相似文献
94.
95.
96.
Percutaneous angioplasty in clinical management of renovascular hypertension: initial and long-term results 总被引:1,自引:0,他引:1
Martin LG; Price RB; Casarella WJ; Sones PJ; Wells JO Jr; Zellmer RA; Chuang VP; Silbiger ML Jr; Berkman WA 《Radiology》1985,155(3):629-633
Between January 1980 and July 1983, percutaneous transluminal angioplasty was attempted on 137 stenotic renal arteries in 100 patients. At termination of follow-up studies (3-39 months, mean of 16 months), 70% of those treated for hypertension had benefited from the procedure. Stenosis secondary to fibromuscular dysplasia responded better than stenosis from arteriosclerosis (85% and 65% of the patients, respectively). Benefit was minimal for those with stenosis of the renal artery ostium or renal insufficiency. Determining levels of renal vein renin before angioplasty is helpful in selecting patients; following angioplasty, this has considerable significance in predicting the success of the procedure. 相似文献
97.
Six healthy subjects in random order underwent gastric bicarbonate secretion investigations, including stimulation with increasing doses of the cholinergic agonist carbachol, sham feeding, fundic distension and gastric instillation of 16,16-dimethyl prostaglandin E2. Bicarbonate secretion was measured by a computer-based system which continuously recorded pH and PCO2 of the effluent in a high-volume gastric perfusion system. The peak 30 min gastric bicarbonate output in response to carbachol, 150 mg subcutaneously, was 114% (P less than 0.05). Vagal stimulation by sham feeding resulted in a corresponding increase of 112% (P less than 0.05), while fundic distension to a volume of 600 ml gave an increase of 114% (P less than 0.05). In comparison, the response to 80 micrograms 16,16-dimethyl prostaglandin E2 was much greater, the peak bicarbonate output being increased by 245% (P less than 0.05). Both sham feeding and fundic distension appear to be either submaximal stimuli of gastric bicarbonate secretion in man or may possess both stimulatory and inhibitory actions. 相似文献
98.
99.
Olof Akre Lina Forssell Magnus Kaijser Ingrid Norén-Nilsson Jesper Lagergren Olof Nyrén Anders Ekbom 《Cancer epidemiology, biomarkers & prevention》2006,15(5):867-871
BACKGROUND: We have previously hypothesized that preterm birth or impaired fetal growth may cause esophageal adenocarcinomas through gastroesophageal reflux early in life. In this study, we aimed to test if there is an association between gestational duration and birth weight on the one hand, and risk of esophageal and cardia adenocarcinoma on the other. METHODS: We conducted a nested case-control study of 67 cases of esophageal adenocarcinoma and 93 cases of cardia adenocarcinoma, whereas 50 cases of squamous cell carcinoma were studied for comparison. Birth records of cases were traced. Three matched controls per case were randomly selected. Perinatal data were extracted from birth records. RESULTS: Long gestational duration was associated with a decreased risk of cardia adenocarcinoma (P(trend) = 0.001) and a nonsignificant decreased risk of esophageal adenocarcinoma (P = 0.07), whereas no such association was found for esophageal squamous cell carcinoma (P = 0.96). Birth weight was not associated with risk of any of the studied cancers. Compared with lower maternal age (=24 years) at giving birth, maternal age of 25 to 29 years were associated with a decreased risk of esophageal adenocarcinoma and squamous cell carcinoma (odds ratio, 0.4; 95% confidence interval, 0.2-0.9 and odds ratio, 0.3; 95% confidence interval, 0.1-0.8, respectively). CONCLUSIONS: Numerical constraints hamper inference, but our results are somewhat consistent with the idea that future risk of esophageal and cardia cancer may in part be determined already perinatally or in infancy and give some limited support to the hypothesis that timing of birth influences risk. 相似文献
100.
K Tullus R Escobar-Billing O Fituri LG Burman A Karlsson I Wikstad B Wretlind A Brauner 《Acta paediatrica (Oslo, Norway : 1992)》1996,85(2):158-162
Urinary concentrations of interleukin-lα (IL-lα) and interleukin-l receptor antagonist (IL-Ira) standardized to urinary creatinine concentrations were studied. The median standardized IL-1α creatinine quotient in children with first-time acute pyelonephritis was 3.6 pg/μmol, but was non-detectable in children with recurrent pyelonephritis, children with non-renal febrile conditions and children convalescent after acute pyelonephritis ( p < 0.05–0.01). IL-lra levels were also significantly higher in children with acute first-time pyelonephritis (median of 239 pglpmol) compared to these three groups of children ( p < 0.01–0.001). The highest urinary 1L-lra levels, however, were found in the healthy controls (median value 1.019; p < 0.001). Both cytokines were higher among children younger than one year compared to older children. The acute IL-lα creatinine quotients were lowest in children with uptake defects on 99m TC-dimercaptosuccinic acid (DMSA) scintigraphy both during the acute infection (reflecting the acute inflammation) ( p < 0.001) and 1 year after the acute infection (reflecting permanent kidney scarring) ( p < 0.01). In conclusion, persisting high urinary levels of 1L-lα were associated with less renal inflammation and scarring. 相似文献