全文获取类型
收费全文 | 651篇 |
免费 | 42篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 41篇 |
妇产科学 | 12篇 |
基础医学 | 89篇 |
口腔科学 | 28篇 |
临床医学 | 44篇 |
内科学 | 123篇 |
皮肤病学 | 16篇 |
神经病学 | 11篇 |
特种医学 | 144篇 |
外国民族医学 | 1篇 |
外科学 | 38篇 |
综合类 | 50篇 |
预防医学 | 37篇 |
眼科学 | 5篇 |
药学 | 21篇 |
中国医学 | 4篇 |
肿瘤学 | 32篇 |
出版年
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 5篇 |
2018年 | 13篇 |
2017年 | 11篇 |
2016年 | 14篇 |
2015年 | 12篇 |
2014年 | 19篇 |
2013年 | 31篇 |
2012年 | 25篇 |
2011年 | 19篇 |
2010年 | 43篇 |
2009年 | 44篇 |
2008年 | 23篇 |
2007年 | 21篇 |
2006年 | 9篇 |
2005年 | 9篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 3篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 7篇 |
1998年 | 34篇 |
1997年 | 33篇 |
1996年 | 34篇 |
1995年 | 35篇 |
1994年 | 23篇 |
1993年 | 20篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 15篇 |
1988年 | 14篇 |
1987年 | 10篇 |
1986年 | 13篇 |
1985年 | 9篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 12篇 |
1981年 | 13篇 |
1980年 | 15篇 |
1979年 | 4篇 |
1978年 | 8篇 |
1977年 | 2篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1955年 | 1篇 |
1950年 | 1篇 |
1949年 | 1篇 |
排序方式: 共有697条查询结果,搜索用时 15 毫秒
101.
102.
Heterogeneity of breakpoints of 11q23 rearrangements in hematologic malignancies identified with fluorescence in situ hybridization 总被引:3,自引:0,他引:3
Kobayashi H; Espinosa R d; Thirman MJ; Gill HJ; Fernald AA; Diaz MO; Le Beau MM; Rowley JD 《Blood》1993,82(2):547-551
Twenty-four patients whose cells contained a variety of 11q23 rearrangements, including translocations, insertions, and an inversion, were studied using fluorescence in situ hybridization with cosmid, phage, and plasmid probes mapped to 11q22-24. In 17 patients, the breakpoints of the common 11q23 translocations involving chromosomes 4, 6, 9, and 19 as well as some uncommon translocations involving 3q23, 17q25, 10p11, and an insertion 10;11 were all located in the breakpoint cluster region of the MLL gene, regardless of age, phenotype of disease, or involvement of a third chromosome. The breakpoints in 11q23 in the other 7 patients with a t(7;11)(p15;q23), inv(11)(p11q23), t(4;11)(q23;q23), der(5)t(5;11)(q13;q23), ins(10;11)(p11;q23q24), t(11;14)(q23;q11), or t(11;18;11) (p15;q21;q23) were located either centromeric to CD3D or telomeric to THY1. Thus, although most 11q23 rearrangements, involve the same breakpoint cluster region of MLL, there is heterogeneity in the breakpoint in some of the rare rearrangements. 相似文献
103.
104.
105.
106.
We present the case of a 19-year-old individual presenting to an orthopaedic outpatient clinic several months following a dashboard knee injury during a road traffic accident with intermittent mechanical symptoms. Despite unremarkable examination findings and normal magnetic resonance imaging, the patient was identified subsequently as having an intra-articular plastic foreign body consistent with a piece of dashboard on arthroscopic knee assessment, the retrieval of which resulted in a complete resolution of symptoms. 相似文献
107.
108.
Clinical Impact of Overexpression of FOXP3 and WT1 on Disease Outcome in Egyptian Acute Myeloid Leukemia Patients 下载免费PDF全文
Magda M AssemAhmed OsmanEman Z KandeelReham AA ElshimyHanan R NassarRadwa E Ali 《Asian Pacific journal of cancer prevention》2016,17(10):4699-4711
Background: In the last decade, it has become clear that change of gene expression may alter the hematopoietic cell quiescent state and consequently play a major role in leukemogenesis. WT1 is known to be a player in acute myeloid leukemia (AML) and FOXP3 has a crucial role in regulating the immune response. Objectives: To evaluate the impact of overexpression of WT1and FOXP3 genes on clinical course in adult and pediatric AML patients in Egypt. Patients and methods: Bone marrow and peripheral blood samples were obtained from 97 de novo non M3 AML patients (63 adult and 34 pediatric). Real-time quantitative PCR was used to detect overexpression WT1 and FOXP3 genes. Patient follow up ranged from 0.2 to 39.0 months with a median of 5 months. Results: In the pediatric group; WT1 was significantly expressed with a high total leukocyte count median 50X109/L (p=0.018). In the adult group, WT1 had an adverse impact on complete remission induction, disease-free survival and overall survival (p=0.02, p=0.035, p=0.019 respectively). FOXP3 overexpression was associated with FAB subtypes AML M0 +M1 vs. M2, M4+M5 (p =0.039) and the presence of hepatomegaly (p=0.005). Conclusions: WT1 and FOXP3 overexpression has an adverse impact on clinical presentation, treatment response and survival of pediatric and adult Egyptian AML patients. 相似文献
109.
110.