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Introduction

Accuracy of implant positioning in total knee arthroplasty (TKA) has a major impact on postoperative outcomes. We investigate the accuracy of positioning of multiples values simultaneously in TKA navigated, even among novice users.

Method

The “novice” group included the first 91 knees operated on by 10 operators new to navigation and the “experienced” group 174 knees by an experienced navigator. Deviations from the preoperative planning were graded as optimal (≤3°), acceptable (4°–5°) or non-acceptable (≥5°). Moreover, the percentage of the three values fulfilling simultaneously the objective was calculated.

Results

No significant difference in the number of non-acceptable results was found. The common objective for these three values was achieved within 5° in 96 % in the novice group and 98 % in the experienced one.

Conclusion

The satisfactory HKA alignment was not the result of reversed errors between the tibia and the femur, since it correlated the successful simultaneous results of alpha and beta angles.  相似文献   
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A sociological conceptualisation of space moves beyond the material to the relational, to consider space as a social process. This paper draws on research that explored the reproduction of legitimated knowledge and power structures in intensive care units during encounters, between patients, who were experiencing mental illness, and their nurses. Semi‐structured telephone interviews with 17 intensive care nurses from eight Australian intensive care units were conducted in 2017. Data were analysed through iterative cycling between participants' responses, the literature and the theoretical framework. The material and relational aspects of space in this context constitute a dynamic process that is concerned with the reproduction of everyday life, the preservation of the biomedical authority of intensive care, and the social othering of people experiencing mental illness. The work of theorists such as Löw, Harvey and Foucault underpins the exploration of space as a multi‐dimensional, malleable social process that both produces and is the product of social interaction and the social world. In this paper, we argue that the performative work of knowledge and power production and reproduction, considered here in relation to intensive care spaces, enables ongoing othering and disenfranchisement of people experiencing mental illness.  相似文献   
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We report the case of a Caucasian woman, operated on for a solid pseudopapillary tumor of the pancreas in 2009, who recurred 4 years later with multiple liver metastases requiring liver resection. This disease is infrequent, particularly among the Caucasian population, and metastatic evolution is very rare.Key Words: Solid pseudopapillary tumor, Pancreas, Metastatic evolution, Caucasian woman  相似文献   
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Basal-like breast cancer is an aggressive tumor subtype with a poor response to conventional therapies. Tumor formation and relapse are sustained by a cell subset of Breast Cancer Stem Cells (BrCSCs). Here we show that miR-100 inhibits maintenance and expansion of BrCSCs in basal-like cancer through Polo-like kinase1 (Plk1) down-regulation. Moreover, miR-100 favors BrCSC differentiation, converting a basal like phenotype into luminal. It induces the expression of a functional estrogen receptor (ER) and renders basal-like BrCSCs responsive to hormonal therapy. The key role played by miR-100 in breast cancer free-survival is confirmed by the analysis of a cohort of patients’ tumors, which shows that low expression of miR-100 is a negative prognostic factor and is associated with gene signatures of high grade undifferentiated tumors. Our findings indicate a new possible therapeutic strategy, which could make aggressive breast cancers responsive to standard treatments.  相似文献   
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