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991.
Luís Paiva José Coelho Sérgio Barra Marco Costa João Sargento-Freitas Luís Cunha Lino Gonçalves 《Revista portuguesa de cardiologia》2021,40(5):357-365
IntroductionThis study aimed to evaluate the performance of non-vitamin K antagonist oral anticoagulation (NOAC) in patients with previous stroke and non-valvular atrial fibrillation (AF) compared with left atrial appendage occlusion (LAAO) in primary and secondary stroke prevention settings.MethodsThis was a prospective, single-center, non-randomized cohort study of 302 consecutive patients with non-valvular AF and at high risk for stroke. Two treatment strategies were compared: LAAO (n=91) and long-term treatment with NOAC (n=149). The primary outcome was the composite endpoint of death, stroke and major bleeding. Propensity score and cause-of-death analyses were performed to compare outcomes.ResultsIn a mean follow-up of 13 months, there were 30 deaths (LAAO 8.8% vs. NOAC 14.8%), five strokes (LAAO 1.1% vs. NOAC 2.7%) and six major bleeds (LAAO 1.1% vs. NOAC 3.4%). There was a non-significant trend for a lower incidence of the primary endpoint in the LAAO group (11.0% vs. 20.9%; HR 0.42, 95% CI 0.17-1.05, p=0.064). Considering only secondary prevention LAAO patients (34.1% of the LAAO group), there was also a non-significant lower incidence of the primary endpoint (LAAO 6.5% vs. 20.9%; HR 0.30, 95% CI 0.07-1.39, p=0.12). While about a fifth of LAAO patients stopped antiplatelet treatment six months after device implantation due to recurrent minor bleeding, no adverse cardiovascular event or major bleeding occurred in this subset of patients.ConclusionIn this registry-based study, LAAO was a reasonable alternative to NOAC for the prevention of a composite endpoint of all-cause mortality, stroke and major bleeding in patients at high risk for stroke. 相似文献
992.
Bartolazzi Frederico Ribeiro Antônio Luiz Pinho de Sousa Waleska Jaclyn Freitas Nunes Vianna Mayara Sousa da Silva José Luiz Padilha Martins Maria Auxiliadora Parreiras 《Journal of thrombosis and thrombolysis》2021,52(4):1074-1080
Journal of Thrombosis and Thrombolysis - Oral anticoagulant therapy (OAT) has increased substantially due to the aging population and prevalence rise of atrial fibrillation (AF). Medication... 相似文献
993.
Molina Collada Juan Macía-Villa Cristina Plasencia Chamaida Álvaro-Gracia José María de Miguel Eugenio 《Clinical rheumatology》2021,40(5):2013-2020
Clinical Rheumatology - To analyse the frequency of power Doppler (PD) enthesitis in active axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients and its potential usefulness in... 相似文献
994.
Bauermeister José A. Tingler Ryan C. Dominguez Clara Dunne Eileen F. Hoesley Craig Ho Ken Johnson Sherri Lucas Jonathan Macagna Nicole Brown Elizabeth Gundacker Holly Peda Melissa Jacobson Cindy E. Kramzer Lindsay Singh Devika Dezzutti Charlene S. Ayudhya Ratiya Pamela Kunjara Na Marzinke Mark A. Piper Jeanna Devlin Bríd Nuttall Jeremy McGowan Ian Hendrix Craig W. Cranston Ross D. 《AIDS and behavior》2022,26(5):1333-1346
AIDS and Behavior - This study describes the acceptability of a rectal microbicide gel formulation using dapivirine (DPV) among men and women from two countries (United States and Thailand)... 相似文献
995.
Mbita Gaspar Komba Albert N. Casalini Caterina Bazant Eva Curran Kelly Christensen Alice Nyato Daniel Kim Young-Mi Reed Jason Makyao Neema Kategile Upendo Conserve Donaldson F. Faini Diana van Roosmalen Jos van den Akker Thomas 《AIDS and behavior》2022,26(10):3185-3198
AIDS and Behavior - The World Health Organization identified men as an essential group to target with HIV testing and treatment strategies;: men who have sex with men (MSM) and male clients of... 相似文献
996.
Eubanks August Coulibaly Bakary Dembélé Keita Bintou Anoma Camille DAH Ter Tiero Elias Mensah Ephrem Maradan Gwenaëlle Bourrelly Michel Mora Marion Riegel Lucas Rojas Castro Daniela Yaya Issifou Spire Bruno Laurent Christian Sagaon-Teyssier Luis 《AIDS and behavior》2022,26(11):3524-3537
AIDS and Behavior - We investigated the rate and predictors of ineffective HIV protection in men who have sex with men (MSM) taking pre-exposure prophylaxis (PrEP) in a prospective cohort study... 相似文献
997.
Vale Paula D. Silva Livia T. M. de Oliveira Edna Maria M. de Miranda Ricardo F. C. da Silva Renato David Araújo Lielia M. C. da Silva Samuel M. P. Cunha Wanessa C. Neto José S. Péres Ayrton K. Seixas Tamer N. da Rocha Jairo M. Margalho Carla S. Maia Henrique Cesar de A. 《Journal of interventional cardiac electrophysiology》2022,63(2):425-430
Journal of Interventional Cardiac Electrophysiology - Delineate retrospectively and prospectively the incidence and characteristics of transient ST-segment elevation during transseptal puncture.... 相似文献
998.
Schmidt Cristine Moreira-Gonçalves Daniel Santos Mário Leite-Moreira Adelino Oliveira José 《Heart failure reviews》2022,27(2):573-586
Heart Failure Reviews - Conventional treatments for heart failure have failed to improve survival in heart failure with preserved ejection fraction (HFpEF). The current therapy recommendations... 相似文献
999.
Daniel Klintman René Schramm Michael D Menger Henrik Thorlacius 《Journal of hepatology》2002,36(1):53-59
BACKGROUND/AIMS: This study was designed to examine the role of selectins and CD18 in leukocyte recruitment in hepatic injury induced by tumor necrosis factor-alpha (TNF-alpha) and galactosamine (Gal) in vivo. METHODS: Intravital fluorescence microscopy of the hepatic microcirculation was used to quantify leukocyte-endothelium interactions provoked by 24 h of systemic TNF-alpha/Gal challenge in rats. Hepatic injury was evaluated with liver enzymes. RESULTS: When administered after 24 h of TNF-alpha/Gal challenge, fucoidan, a selectin-function inhibitor, reduced leukocyte rolling by 69%, whereas firm adhesion was unaltered. In contrast, passive immunization against CD18 decreased leukocyte adhesion by 60%, whereas rolling remained unchanged. Notably, when administered prior to TNF-alpha/Gal, fucoidan attenuated both leukocyte rolling and adhesion, by 57 and 69%, respectively. Pretreatment with an anti-CD18 antibody decreased TNF-alpha/Gal-induced rolling and firm adhesion by 25 and 90%, respectively. Moreover, pretreatment with fucoidan and the anti-CD18 antibody both protected against TNF-alpha/Gal-induced increases in liver enzymes. For example, the pretreatments reduced alanine aminotransferase by 59 and 87%, respectively. CONCLUSIONS: Our data suggest that TNF-alpha/Gal-induced leukocyte rolling is selectin-mediated and a precondition for CD18-dependent firm adhesion in hepatic venules. Thus, reducing leukocyte recruitment by inhibition of selectins or CD18 may be useful to control TNF-alpha-induced liver injury. 相似文献
1000.
José Eduardo Monteiro Cunha Paulo Herman Marcel C. C. Machado Sonia Penteado Fauze Maluf Filho José Jukemura Telésforo Bacchella Emílio E. Abdo 《Journal of hepato-biliary-pancreatic sciences》2002,9(2):261-264
Intrahepatic stone disease poses a difficult postoperative management problem due to frequent stone recurrence. Most of the methods proposed for long-term access to the intrahepatic biliary tree require multiple sessions of additional, usually invasive, procedures. An alternative method for endoscopic long-term access to the intrahepatic ducts, represented by a side-to-side anastomosis between the isolated Roux-en-Y jejunal limb of the bilioenteric bypass and the duodenum (duodenojejunostomy), was used in eight patients with retained and/or recurrent stones after surgical treatment of intrahepatic stone disease. There were no short- or long-term complications or mortality associated with the duodenojejunostomy. Postoperative endoscopic access to the intrahepatic ducts was successfully achieved in five of six patients: one with stone recurrence, one with a left hepatic duct stricture and stone recurrence and one with known retained postoperative stones. In two patients, no stones were found at endoscopy. Side-to-side duodenojejunostomy may be useful in the long-term endoscopic management of recurrent intrahepatic biliary stone disease and should be indicated whenever a bilioenteric anastomosis is performed for the treatment of bilateral intrahepatic stone disease. Introduction 相似文献