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101.
Improvement in quality of life of patients with AL amyloidosis treated with high-dose melphalan and autologous stem cell transplantation
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Seldin DC Anderson JJ Sanchorawala V Malek K Wright DG Quillen K Finn KT Berk JL Dember LM Falk RH Skinner M 《Blood》2004,104(6):1888-1893
Treatment of AL amyloidosis patients with high-dose melphalan chemotherapy followed by autologous peripheral blood stem cell transplantation (HDM/SCT) can produce hematologic complete responses (CRs) and improvement in organ function. To determine whether these responses are accompanied by improvement in quality of life (QOL), we employed the Medical Outcomes Study (MOS) 36-item Short Form General Health Survey (SF-36) questionnaire for 544 patients evaluated between 1994 and 2002. At baseline, the scores were significantly lower on all 8 SF-36 scales compared with age-matched population norms: the composite physical component summary (PCS) for the AL patients was 34.5 versus the population norm of 46.8, and the mental component summary (MCS) was 45.0 versus the norm of 51.5. All SF-36 scores improved at 1 year, with the MCS reaching the population norm. The PCS, though improved, was still lower than normal but was greater in the subgroup of patients who achieved a hematologic CR; the PCS normalized at 2 years in these patients. Thus, treatment of AL amyloidosis patients with HDM/SCT produces measurable and sustained improvements in quality of life, particularly in those patients who achieve hematologic CR. 相似文献
102.
Impact of Providing a Combination Lipid Emulsion Compared With a Standard Soybean Oil Lipid Emulsion in Children Receiving Parenteral Nutrition
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Kristen Lawler Finn DCN RD Mei Chung PhD MPH Pamela Rothpletz‐Puglia EdD RD Laura Byham‐Gray PhD RD 《JPEN. Journal of parenteral and enteral nutrition》2015,39(6):656-667
Background: Soybean oil lipid emulsion may compromise immune function and promote hepatic damage due to its composition of long‐chain fatty acids, phytosterols, high proportion of ω‐6 fatty acids, and low α‐tocopherol levels. Combination lipid emulsions have been developed using medium‐chain triglyceride oil, fish oil, and/or olive oil, which provide adequate essential fatty acids, a smaller concentration of ω‐6 fatty acids, and lower levels of phytosterols. The purpose of this systematic review is to determine if combination lipid emulsions have a more favorable impact on bilirubin levels, triglyceride levels, and incidence of infection compared with soybean oil lipid emulsions in children receiving parenteral nutrition. Methods: This study comprises a systematic review of published studies. Data were sufficient and homogeneous to conduct a meta‐analysis for total bilirubin and infection. Results: Nine studies met the inclusion criteria. Meta‐analysis showed that combination lipid emulsion decreased total bilirubin by a mean difference of 2.09 mg/dL (95% confidence interval, –4.42 to 0.24) compared with soybean oil lipid emulsion, although the result was not statistically significant (P = .08). Meta‐analysis revealed no statistically significant difference in incidence of infection between the combination lipid emulsion and the soybean oil lipid emulsion groups (P = .846). None of the 4 studies that included triglyceride as an outcome detected a significant difference in triglyceride levels between the combination lipid emulsion and soybean oil lipid emulsion groups. Conclusion: There is inadequate evidence that combination lipid emulsions offer any benefit regarding bilirubin levels, triglyceride levels, or incidence of infection compared with soybean oil lipid emulsions. 相似文献
103.
Finn Akerström MBChB Alberto Puchol MD Marta Pachón MD Cristina Martín‐Sierra MD Luis Rodíguez‐Padial MD PhD Miguel A. Arias MD PhD 《Pacing and clinical electrophysiology : PACE》2018,41(10):1362-1364
A 16‐year‐old male presented with an orthodromic atrioventricular reentrant tachycardia over a concealed parahisian accessory pathway (AP). Cryoablation of the AP resulted in transient manifestation of a fully preexcited sinus rhythm of parahisian AP morphology. Potential causes for the paradoxical preexcitation include inadvertent atrioventricular nodal block, sourse‐sink mismatch, as well as the activation of a dormant AP capable of anterograde conduction. 相似文献
104.
Understanding patients and spouses experiences of patient education following a cardiac event and eliciting attitudes and preferences towards incorporating cardiopulmonary resuscitation training: A qualitative study
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Susie Cartledge Susan Feldman Janet E. Bray Dion Stub Judith Finn 《Journal of advanced nursing》2018,74(5):1157-1169
105.
Elizabeth Marlow PhD C‐FNP Marcianna Nosek PhD MPH CNM CNL Yema Lee Earthy Young Alejandra Bautista Finn Thorbjørn Hansen PhD 《Nursing philosophy》2015,16(1):19-28
This paper describes the first phase of an ongoing education and research project guided by three main intentions: (1) to create opportunities for phronesis in the classroom; (2) to develop new understandings about phronesis as it relates to nursing care generally and to caring for specific groups, like formerly incarcerated adults; and (3) to provide an opportunity for formerly incarcerated adults and graduate nursing students to participate in a dialectical conversation about ethical knowing. Gadamer's writings on practical philosophy, phronesis, and the Socratic dialectic provide the philosophical foundation and framework for the project. The first phase in the project was a 4‐h class within a graduate‐level health promotion course during which 30 nursing students and three formerly incarcerated panelists engaged in a dialectic conversation about what it means to care for formerly incarcerated adults in a meaningful way. After the class, two focus groups were conducted, one with the students and one with the formerly incarcerated panelists. Findings articulated participants' prejudices and assumptions prior to the class, expanded sense of phronesis, and ability to consider nursing practice within a larger ethical framework. Panelists and students left the class with a deeper understanding of one another and expressed an openness towards continued dialectic conversations together. Use of the Socratic dialectic within nursing curricula reflects a current and critical trend in nursing education to bring non‐epistemologic forms of knowledge into the classroom. 相似文献
106.
Philippe Généreux Nicolo Piazza Maria C. Alu Tamim Nazif Rebecca T. Hahn Philippe Pibarot Jeroen J. Bax Jonathon A. Leipsic Philipp Blanke Eugene H. Blackstone Matthew T. Finn Samir Kapadia Axel Linke Michael J. Mack Raj Makkar Roxana Mehran Jeffrey J. Popma Martin B. Leon 《Journal of the American College of Cardiology》2021,77(21):2717-2746
107.
Okusaka Takuji Ikeda Kenji Kudo Masatoshi Finn Richard Qin Shukui Han Kwang-Hyub Cheng Ann-Lii Piscaglia Fabio Kobayashi Masahiro Sung Max Chen Minshan Wyrwicz Lucjan Yoon Jung-Hwan Ren Zhenggang Mody Kalgi Dutcus Corina Tamai Toshiyuki Ren Min Hayato Seiichi Kumada Hiromitsu 《Journal of gastroenterology》2021,56(6):570-580
Journal of Gastroenterology - REFLECT was an open-label, phase 3 study comparing the efficacy and safety of lenvatinib versus sorafenib in patients with unresectable hepatocellular carcinoma... 相似文献
108.
Thomas J. Fogarty MD Thomas B. Kinney MS James C. Finn BA 《The American journal of cardiology》1984,53(12):C92-C93
Both balloon catheters and guiding catheters for PTCA are high-quality instruments with an advanced degree of reliability and practicality. The standard set-up at Emory University consists of a steerable 3.0-mm balloon catheter and a Judkins-type guiding catheter. 相似文献
109.
Erika Assarsson Jason A. Greenbaum Magnus Sundstr?m Lana Schaffer Jennifer A. Hammond Valerie Pasquetto Carla Oseroff R. Curtis Hendrickson Elliot J. Lefkowitz David C. Tscharke John Sidney Howard Grey Steven R. Head Bjoern Peters Alessandro Sette 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(40):E63-E64
110.
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection 总被引:4,自引:0,他引:4
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Zaunders JJ Munier ML Kaufmann DE Ip S Grey P Smith D Ramacciotti T Quan D Finlayson R Kaldor J Rosenberg ES Walker BD Cooper DA Kelleher AD 《Blood》2005,106(5):1660-1667
We investigated whether HIV-1 antigen-specific CD4(+) T cells expressed the viral coreceptor CCR5 during primary HIV-1 infection (PHI). In the peripheral blood of subjects with very early PHI (< 22 days after onset of symptoms), there was a 10- to 20-fold increase in the proportion of highly activated (CD38(+++)) and proliferating (Ki-67(+)) CD4(+) T cells that expressed CCR5(+), and were mostly T-cell intracellular antigen-1 (TIA-1)(+) perforin(+) granzyme B(+). Inthe same patient samples, CD4(+) T cells producing interferon (IFN)-gamma in response to HIV group-specific antigen (Gag) peptides were readily detected (median, 0.58%) by intracellular cytokine assay-these cells were again predominantly CD38(+++), Ki-67(+), and TIA-(++), as well as Bcl-2(low). On average, 20% of the Gag-specific CD4(+) T cells also expressed interleukin-2 (IL-2) and were CD127 (IL-7R)(+). Taken together, these results suggest that Gag-specific T-helper 1 (Th1) effector cells express CCR5 during the primary response and may include precursors of long-term self-renewing memory cells. However, in PHI subjects with later presentation, antigen-specific CD4(+) T cells could not be readily detected (median, 0.08%), coinciding with a 5-fold lower level of the CCR5(+)CD38(+++) CD4(+) T cells. These results suggest that the antiviral response to HIV-1 infection includes highly activated CCR5(+)CD4(+) cytotoxic effector cells, which are susceptible to both apoptosis and cytopathic infection with HIV-1, and rapidly decline. 相似文献